7T3A

GATOR1-RAG-RAGULATOR - Inhibitory Complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005096	molecular_function	GTPase activator activity
A	0005737	cellular_component	cytoplasm
A	0005764	cellular_component	lysosome
A	0005765	cellular_component	lysosomal membrane
A	0005829	cellular_component	cytosol
A	0010508	biological_process	positive regulation of autophagy
A	0031267	molecular_function	small GTPase binding
A	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
A	0034198	biological_process	cellular response to amino acid starvation
A	0035556	biological_process	intracellular signal transduction
A	0044877	molecular_function	protein-containing complex binding
A	0048471	cellular_component	perinuclear region of cytoplasm
A	1904262	biological_process	negative regulation of TORC1 signaling
A	1990130	cellular_component	GATOR1 complex
B	0005096	molecular_function	GTPase activator activity
B	0005515	molecular_function	protein binding
B	0005765	cellular_component	lysosomal membrane
B	0005774	cellular_component	vacuolar membrane
B	0033673	biological_process	negative regulation of kinase activity
B	0034198	biological_process	cellular response to amino acid starvation
B	1904262	biological_process	negative regulation of TORC1 signaling
B	1990130	cellular_component	GATOR1 complex
C	0005096	molecular_function	GTPase activator activity
C	0005515	molecular_function	protein binding
C	0005765	cellular_component	lysosomal membrane
C	0010508	biological_process	positive regulation of autophagy
C	0032007	biological_process	negative regulation of TOR signaling
C	0034198	biological_process	cellular response to amino acid starvation
C	1904262	biological_process	negative regulation of TORC1 signaling
C	1990130	cellular_component	GATOR1 complex
K	0000166	molecular_function	nucleotide binding
K	0003924	molecular_function	GTPase activity
K	0005515	molecular_function	protein binding
K	0005525	molecular_function	GTP binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005737	cellular_component	cytoplasm
K	0005764	cellular_component	lysosome
K	0005765	cellular_component	lysosomal membrane
K	0005829	cellular_component	cytosol
K	0006915	biological_process	apoptotic process
K	0008104	biological_process	intracellular protein localization
K	0009267	biological_process	cellular response to starvation
K	0010507	biological_process	negative regulation of autophagy
K	0016787	molecular_function	hydrolase activity
K	0031625	molecular_function	ubiquitin protein ligase binding
K	0031669	biological_process	cellular response to nutrient levels
K	0032008	biological_process	positive regulation of TOR signaling
K	0033209	biological_process	tumor necrosis factor-mediated signaling pathway
K	0034198	biological_process	cellular response to amino acid starvation
K	0035556	biological_process	intracellular signal transduction
K	0042593	biological_process	glucose homeostasis
K	0042803	molecular_function	protein homodimerization activity
K	0043495	molecular_function	protein-membrane adaptor activity
K	0046982	molecular_function	protein heterodimerization activity
K	0051219	molecular_function	phosphoprotein binding
K	0061462	biological_process	protein localization to lysosome
K	0071230	biological_process	cellular response to amino acid stimulus
K	0072657	biological_process	protein localization to membrane
K	1904263	biological_process	positive regulation of TORC1 signaling
K	1990130	cellular_component	GATOR1 complex
K	1990131	cellular_component	Gtr1-Gtr2 GTPase complex
K	1990877	cellular_component	FNIP-folliculin RagC/D GAP
L	0000166	molecular_function	nucleotide binding
L	0000287	molecular_function	magnesium ion binding
L	0003924	molecular_function	GTPase activity
L	0005515	molecular_function	protein binding
L	0005525	molecular_function	GTP binding
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005737	cellular_component	cytoplasm
L	0005764	cellular_component	lysosome
L	0005765	cellular_component	lysosomal membrane
L	0005829	cellular_component	cytosol
L	0006351	biological_process	DNA-templated transcription
L	0006915	biological_process	apoptotic process
L	0007264	biological_process	small GTPase-mediated signal transduction
L	0008104	biological_process	intracellular protein localization
L	0008380	biological_process	RNA splicing
L	0009267	biological_process	cellular response to starvation
L	0010507	biological_process	negative regulation of autophagy
L	0016787	molecular_function	hydrolase activity
L	0019003	molecular_function	GDP binding
L	0031669	biological_process	cellular response to nutrient levels
L	0032006	biological_process	regulation of TOR signaling
L	0034198	biological_process	cellular response to amino acid starvation
L	0043200	biological_process	response to amino acid
L	0043495	molecular_function	protein-membrane adaptor activity
L	0046982	molecular_function	protein heterodimerization activity
L	0051020	molecular_function	GTPase binding
L	0060090	molecular_function	molecular adaptor activity
L	0061462	biological_process	protein localization to lysosome
L	0071230	biological_process	cellular response to amino acid stimulus
L	0072657	biological_process	protein localization to membrane
L	0140767	molecular_function	enzyme-substrate adaptor activity
L	1903432	biological_process	regulation of TORC1 signaling
L	1904263	biological_process	positive regulation of TORC1 signaling
L	1990131	cellular_component	Gtr1-Gtr2 GTPase complex
L	1990877	cellular_component	FNIP-folliculin RagC/D GAP
M	0001558	biological_process	regulation of cell growth
M	0001919	biological_process	regulation of receptor recycling
M	0005085	molecular_function	guanyl-nucleotide exchange factor activity
M	0005515	molecular_function	protein binding
M	0005764	cellular_component	lysosome
M	0005765	cellular_component	lysosomal membrane
M	0005886	cellular_component	plasma membrane
M	0007032	biological_process	endosome organization
M	0007040	biological_process	lysosome organization
M	0008104	biological_process	intracellular protein localization
M	0010874	biological_process	regulation of cholesterol efflux
M	0016197	biological_process	endosomal transport
M	0031669	biological_process	cellular response to nutrient levels
M	0031902	cellular_component	late endosome membrane
M	0032008	biological_process	positive regulation of TOR signaling
M	0032418	biological_process	lysosome localization
M	0035577	cellular_component	azurophil granule membrane
M	0035579	cellular_component	specific granule membrane
M	0038202	biological_process	TORC1 signaling
M	0042632	biological_process	cholesterol homeostasis
M	0043410	biological_process	positive regulation of MAPK cascade
M	0043495	molecular_function	protein-membrane adaptor activity
M	0045121	cellular_component	membrane raft
M	0051020	molecular_function	GTPase binding
M	0060090	molecular_function	molecular adaptor activity
M	0060620	biological_process	regulation of cholesterol import
M	0070062	cellular_component	extracellular exosome
M	0071230	biological_process	cellular response to amino acid stimulus
M	0071986	cellular_component	Ragulator complex
M	0072657	biological_process	protein localization to membrane
M	0101003	cellular_component	ficolin-1-rich granule membrane
M	0150032	biological_process	positive regulation of protein localization to lysosome
M	1904263	biological_process	positive regulation of TORC1 signaling
M	1990877	cellular_component	FNIP-folliculin RagC/D GAP
N	0001558	biological_process	regulation of cell growth
N	0005085	molecular_function	guanyl-nucleotide exchange factor activity
N	0005737	cellular_component	cytoplasm
N	0005765	cellular_component	lysosomal membrane
N	0005770	cellular_component	late endosome
N	0005886	cellular_component	plasma membrane
N	0008104	biological_process	intracellular protein localization
N	0010008	cellular_component	endosome membrane
N	0031902	cellular_component	late endosome membrane
N	0032008	biological_process	positive regulation of TOR signaling
N	0035579	cellular_component	specific granule membrane
N	0038202	biological_process	TORC1 signaling
N	0060090	molecular_function	molecular adaptor activity
N	0070821	cellular_component	tertiary granule membrane
N	0071230	biological_process	cellular response to amino acid stimulus
N	0071986	cellular_component	Ragulator complex
N	0150116	biological_process	regulation of cell-substrate junction organization
N	1902533	biological_process	positive regulation of intracellular signal transduction
N	1904263	biological_process	positive regulation of TORC1 signaling
N	1990877	cellular_component	FNIP-folliculin RagC/D GAP
O	0005085	molecular_function	guanyl-nucleotide exchange factor activity
O	0005515	molecular_function	protein binding
O	0005737	cellular_component	cytoplasm
O	0005765	cellular_component	lysosomal membrane
O	0005770	cellular_component	late endosome
O	0005886	cellular_component	plasma membrane
O	0005925	cellular_component	focal adhesion
O	0008104	biological_process	intracellular protein localization
O	0010008	cellular_component	endosome membrane
O	0019209	molecular_function	kinase activator activity
O	0031902	cellular_component	late endosome membrane
O	0032006	biological_process	regulation of TOR signaling
O	0032008	biological_process	positive regulation of TOR signaling
O	0035579	cellular_component	specific granule membrane
O	0038202	biological_process	TORC1 signaling
O	0060090	molecular_function	molecular adaptor activity
O	0070062	cellular_component	extracellular exosome
O	0070821	cellular_component	tertiary granule membrane
O	0071230	biological_process	cellular response to amino acid stimulus
O	0071986	cellular_component	Ragulator complex
O	1902533	biological_process	positive regulation of intracellular signal transduction
O	1904263	biological_process	positive regulation of TORC1 signaling
O	1990877	cellular_component	FNIP-folliculin RagC/D GAP
P	0005085	molecular_function	guanyl-nucleotide exchange factor activity
P	0005515	molecular_function	protein binding
P	0005764	cellular_component	lysosome
P	0005765	cellular_component	lysosomal membrane
P	0008361	biological_process	regulation of cell size
P	0031902	cellular_component	late endosome membrane
P	0032008	biological_process	positive regulation of TOR signaling
P	0038202	biological_process	TORC1 signaling
P	0060090	molecular_function	molecular adaptor activity
P	0061462	biological_process	protein localization to lysosome
P	0071230	biological_process	cellular response to amino acid stimulus
P	0071986	cellular_component	Ragulator complex
P	1904263	biological_process	positive regulation of TORC1 signaling
P	1990877	cellular_component	FNIP-folliculin RagC/D GAP
Q	0005085	molecular_function	guanyl-nucleotide exchange factor activity
Q	0005515	molecular_function	protein binding
Q	0005737	cellular_component	cytoplasm
Q	0005764	cellular_component	lysosome
Q	0005765	cellular_component	lysosomal membrane
Q	0005829	cellular_component	cytosol
Q	0008361	biological_process	regulation of cell size
Q	0009615	biological_process	response to virus
Q	0010628	biological_process	positive regulation of gene expression
Q	0019079	biological_process	viral genome replication
Q	0031902	cellular_component	late endosome membrane
Q	0032008	biological_process	positive regulation of TOR signaling
Q	0032757	biological_process	positive regulation of interleukin-8 production
Q	0032991	cellular_component	protein-containing complex
Q	0038202	biological_process	TORC1 signaling
Q	0043066	biological_process	negative regulation of apoptotic process
Q	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
Q	0060090	molecular_function	molecular adaptor activity
Q	0061462	biological_process	protein localization to lysosome
Q	0071230	biological_process	cellular response to amino acid stimulus
Q	0071986	cellular_component	Ragulator complex
Q	1900182	biological_process	positive regulation of protein localization to nucleus
Q	1904263	biological_process	positive regulation of TORC1 signaling
Q	1990877	cellular_component	FNIP-folliculin RagC/D GAP

Functional Information from PROSITE/UniProt

site_id	PS00214
Number of Residues	18
Details	FABP Cytosolic fatty-acid binding proteins signature. KAYkVnpDmNFEvFIHKV

Chain	Residue	Details
L	LYS163-VAL180

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"35338845","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7T3C","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Site: {"description":"Arginine finger","evidences":[{"source":"PubMed","id":"30651352","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"Asymmetric dimethylarginine","evidences":[{"source":"PubMed","id":"38006878","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"36528027","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31601708","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36697823","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6U62","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UX2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"35338845","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36103527","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7T3B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T3C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DHB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31601764","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36697823","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6SB0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6SB2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UX2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31601708","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31601764","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36697823","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6SB0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6SB2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6U62","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UX2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31601708","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31601764","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6SB0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6SB2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6U62","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31672913","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31704029","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32868926","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35338845","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6NZD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6ULG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WJ2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WJ3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T3B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T3C","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31704029","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32868926","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6ULG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WJ2","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	5
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"25936802","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31601708","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31601764","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35338845","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36697823","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6SB0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6SB2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6U62","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T3C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UX2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31601764","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35338845","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6SB0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6SB2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T3B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T3C","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31601708","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31601764","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35338845","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36697823","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6SB0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6U62","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T3B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UX2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"32868926","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36697823","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6WJ2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WJ3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UX2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31601708","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31601764","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32868926","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35338845","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36697823","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6SB0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6SB2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6U62","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WJ2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WJ3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T3B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UX2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31601764","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35338845","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36697823","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6SB0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6SB2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T3C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UX2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"32868926","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6WJ2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WJ3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"35338845","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7T3B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T3C","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31601708","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32868926","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36697823","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6U62","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WJ2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WJ3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UX2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI22
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31601708","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35338845","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36697823","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6U62","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T3B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UX2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI23
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"35338845","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36697823","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7T3B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UX2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI24
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q99K70","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI25
Number of Residues	3
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI26
Number of Residues	1
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"36476874","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI27
Number of Residues	3
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"UniProtKB","id":"Q9CQ22","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI28
Number of Residues	13
Details	Region: {"description":"Required for location at endosomes","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI29
Number of Residues	13
Details	Region: {"description":"Required for interaction with LAMTOR2","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI30
Number of Residues	1
Details	Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI31
Number of Residues	1
Details	Modified residue: {"description":"N-acetylthreonine; in Ragulator complex protein LAMTOR4, N-terminally processed","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"25944712","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI32
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine; by PKA","evidences":[{"source":"PubMed","id":"31314152","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI33
Number of Residues	1
Details	Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUL-2005","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Quadroni M."]}},{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"25944712","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---