Alpha Synuclein fibril formed by full length protein - Rod Polymorph

Summary for 6CU7

EMDB information7618
DescriptorAlpha-synuclein (1 entity in total)
Functional Keywordsparkinson's disease, synucleinopathy, amyloid aggregation, fibril polymorphism, protein fibril
Biological sourceHomo sapiens (Human)
Total number of polymer chains10
Total molecular weight144761.08
Li, B.,Hatami, A.,Ge, P.,Murray, K.A.,Sheth, P.,Zhang, M.,Nair, G.,Sawaya, M.R.,Zhu, C.,Broad, M.,Shin, W.S.,Ye, S.,John, V.,Eisenberg, D.S.,Zhou, Z.H.,Jiang, L. (deposition date: 2018-03-23, release date: 2018-09-12, Last modification date: 2018-09-19)
Primary citation
Li, B.,Ge, P.,Murray, K.A.,Sheth, P.,Zhang, M.,Nair, G.,Sawaya, M.R.,Shin, W.S.,Boyer, D.R.,Ye, S.,Eisenberg, D.S.,Zhou, Z.H.,Jiang, L.
Cryo-EM of full-length alpha-synuclein reveals fibril polymorphs with a common structural kernel.
Nat Commun, 9:3609-3609, 2018
PubMed: 30190461 (PDB entries with the same primary citation)
DOI: 10.1038/s41467-018-05971-2
MImport into Mendeley
Experimental method

Structure validation

ClashscoreRamachandran outliersSidechain outliers500MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all EM structures

More Asymmetric unit images

Molmil generated image of 6cu7
no rotation
Molmil generated image of 6cu7
rotated about x axis by 90°
Molmil generated image of 6cu7
rotated about y axis by 90°
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