7F8N

Human pannexin-1 showing a conformational change in the N-terminal domain and blocked pore

Summary for 7F8N

Entry DOI	10.2210/pdb7f8n/pdb
EMDB information	31490
Descriptor	Pannexin-1, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (2 entities in total)
Functional Keywords	atp release channel, vertebrate innexin homolog, transport protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	7
Total formula weight	373900.76
Authors	Kuzuya, M.,Hirano, H.,Hayashida, K.,Watanabe, M.,Kobayashi, K.,Tani, K.,Fujiyoshi, Y.,Oshima, A. (deposition date: 2021-07-02, release date: 2022-01-26, Last modification date: 2022-02-23)
Primary citation	Kuzuya, M.,Hirano, H.,Hayashida, K.,Watanabe, M.,Kobayashi, K.,Terada, T.,Mahmood, M.I.,Tama, F.,Tani, K.,Fujiyoshi, Y.,Oshima, A. Structures of human pannexin-1 in nanodiscs reveal gating mediated by dynamic movement of the N terminus and phospholipids. Sci.Signal., 15:eabg6941-eabg6941, 2022 Cited by PubMed: 35133866 DOI: 10.1126/scisignal.abg6941 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.4 Å)

Structure validation