PDB: 141 resultsInfo pagesStatus searchChemie searchBIRD

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1KI1	Guanine Nucleotide Exchange Region of Intersectin in Complex with Cdc42 Descriptor: G25K GTP-binding protein, placental isoform, SULFATE ION, ... Authors: Snyder, J.T, Pruitt, W.M, Der, C.J, Sondek, J. Deposit date: 2001-12-02 Release date: 2002-05-29 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural basis for the selective activation of Rho GTPases by Dbl exchange factors. Nat.Struct.Biol., 9, 2002
1KZ7	Crystal Structure of the DH/PH Fragment of Murine Dbs in Complex with the Placental Isoform of Human Cdc42 Descriptor: CDC42 HOMOLOG, GUANINE NUCLEOTIDE EXCHANGE FACTOR DBS Authors: Rossman, K.L, Worthylake, D.K, Snyder, J.T, Siderovski, D.P, Campbell, S.L, Sondek, J. Deposit date: 2002-02-06 Release date: 2002-03-20 Last modified: 2021-10-27 Method: X-RAY DIFFRACTION (2.4 Å) Cite: A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange. EMBO J., 21, 2002
1LB1	Crystal Structure of the Dbl and Pleckstrin homology domains of Dbs in complex with RhoA Descriptor: Guanine nucleotide exchange factor DBS, Transforming protein RhoA Authors: Snyder, J.T, Worthylake, D.K, Rossman, K.L, Betts, L, Pruitt, W.M, Siderovski, D.P, Der, C.J, Sondek, J. Deposit date: 2002-04-01 Release date: 2002-05-29 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (2.81 Å) Cite: Structural basis for the selective activation of Rho GTPases by Dbl exchange factors. Nat.Struct.Biol., 9, 2002
1KZG	DbsCdc42(Y889F) Descriptor: CDC42 HOMOLOG, GUANINE NUCLEOTIDE EXCHANGE FACTOR DBS Authors: Rossman, K.L, Worthylake, D.K, Snyder, J.T, Siderovski, D.P, Campbell, S.L, Sondek, J. Deposit date: 2002-02-06 Release date: 2002-03-20 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (2.6 Å) Cite: A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange. EMBO J., 21, 2002
6NFA	Vav1 inhibited by an allosteric inhibitor: Vav1 inhibitors block GEF activity Descriptor: (2S)-2-{[3-(4-methylphenyl)imidazo[1,2-a]pyrazin-8-yl]amino}-3-(pyridin-3-yl)propan-1-ol, Proto-oncogene vav, ZINC ION Authors: Knapp, M.S, Elling, R.A, Ornelas, E. Deposit date: 2018-12-19 Release date: 2019-12-25 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Allosteric Inhibitors of VAV1 Block Guanine Nucleotide Exchange Activity To Be Published
6NEW	Apo structure of the activated truncation of Vav1 Descriptor: Proto-oncogene vav, ZINC ION Authors: Knapp, M.S, Elling, R.A, Ornelas, E. Deposit date: 2018-12-18 Release date: 2019-12-25 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Allosteric Inhibitors of VAV1 Block Guanine Nucleotide Exchange Activity To Be Published
6NF1	Vav1 inhibited by an allosteric inhibitor: Vav1 inhibitors block GEF activity Descriptor: (2S)-3-[(3S)-1-(ethylsulfonyl)piperidin-3-yl]-2-{[3-(4-methylphenyl)imidazo[1,2-a]pyrazin-8-yl]amino}propan-1-ol, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Proto-oncogene vav, ... Authors: Knapp, M.S, Elling, R.A, Ornelas, E. Deposit date: 2018-12-18 Release date: 2019-12-25 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Allosteric Inhibitors of VAV1 Block Guanine Nucleotide Exchange Activity To Be Published
5FI0	Crystal Structure of the P-Rex1 DH/PH tandem in complex with Rac1 Descriptor: PHOSPHATE ION, Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein,Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein, Ras-related C3 botulinum toxin substrate 1 Authors: Cash, J.N, Tesmer, J.J.G. Deposit date: 2015-12-22 Release date: 2016-04-20 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (3.282 Å) Cite: Structural and Biochemical Characterization of the Catalytic Core of the Metastatic Factor P-Rex1 and Its Regulation by PtdIns(3,4,5)P3. Structure, 24, 2016
5FI1	Crystal Structure of the P-Rex1 DH/PH tandem in complex with Cdc42 Descriptor: Cell division control protein 42 homolog, Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein,Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein Authors: Cash, J.N, Tesmer, J.J.G. Deposit date: 2015-12-22 Release date: 2016-04-20 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (3.203 Å) Cite: Structural and Biochemical Characterization of the Catalytic Core of the Metastatic Factor P-Rex1 and Its Regulation by PtdIns(3,4,5)P3. Structure, 24, 2016
1X86	Crystal Structure of the DH/PH domains of Leukemia-associated RhoGEF in complex with RhoA Descriptor: PHOSPHATE ION, Rho guanine nucleotide exchange factor 12, Transforming protein RhoA Authors: Kristelly, R, Gao, G, Tesmer, J.J. Deposit date: 2004-08-17 Release date: 2004-09-21 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (3.22 Å) Cite: Structural determinants of RhoA binding and nucleotide exchange in leukemia-associated Rho guanine-nucleotide exchange factor. J.Biol.Chem., 279, 2004
1XDV	Experimentally Phased Structure of Human the Son of Sevenless protein at 4.1 Ang. Descriptor: Son of sevenless protein homolog 1 Authors: Sondermann, H, Soisson, S.M, Boykevisch, S, Yang, S.S, Bar-Sagi, D, Kuriyan, J. Deposit date: 2004-09-08 Release date: 2004-11-02 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (4.1 Å) Cite: Structural analysis of autoinhibition in the ras activator son of sevenless. Cell(Cambridge,Mass.), 119, 2004
1XD4	Crystal structure of the DH-PH-cat module of Son of Sevenless (SOS) Descriptor: Son of sevenless protein homolog 1 Authors: Sondermann, H, Soisson, S.M, Boykevisch, S, Yang, S.S, Bar-Sagi, D, Kuriyan, J. Deposit date: 2004-09-03 Release date: 2004-11-02 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (3.64 Å) Cite: Structural analysis of autoinhibition in the ras activator son of sevenless. Cell(Cambridge,Mass.), 119, 2004
3QBV	Structure of designed orthogonal interaction between CDC42 and nucleotide exchange domains of intersectin Descriptor: Cell division control protein 42 homolog, GUANOSINE-5'-DIPHOSPHATE, Intersectin-1 Authors: Kapp, G.T, Remenyi, A, Lim, W.A, Kortemme, T. Deposit date: 2011-01-14 Release date: 2012-02-08 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.65 Å) Cite: Control of protein signaling using a computationally designed GTPase/GEF orthogonal pair. Proc.Natl.Acad.Sci.USA, 109, 2012
1XCG	Crystal Structure of Human RhoA in complex with DH/PH fragment of PDZRHOGEF Descriptor: Rho guanine nucleotide exchange factor 11, Transforming protein RhoA Authors: Derewenda, U, Oleksy, A, Stevenson, A.S, Korczynska, J, Dauter, Z, Somlyo, A.P, Otlewski, J, Somlyo, A.V, Derewenda, Z.S. Deposit date: 2004-09-01 Release date: 2004-12-14 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.5 Å) Cite: The crystal structure of RhoA in complex with the DH/PH fragment of PDZRhoGEF, an activator of the Ca(2+) sensitization pathway in smooth muscle Structure, 12, 2004
3JV3	Structure of SH3E-DH unit of murine intersectin-1L Descriptor: Intersectin-1 Authors: Ahmad, K.F. Deposit date: 2009-09-15 Release date: 2010-07-14 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.4 Å) Cite: The minimal autoinhibited unit of the guanine nucleotide exchange factor intersectin. Plos One, 5, 2010
3JZY	Crystal structure of human Intersectin 2 C2 domain Descriptor: Intersectin 2, UNKNOWN ATOM OR ION Authors: Shen, Y, Tempel, W, Tong, Y, Li, Y, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC) Deposit date: 2009-09-24 Release date: 2009-10-06 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.56 Å) Cite: Crystal structure of human Intersectin 2 C2 domain To be Published
3KZ1	Crystal Structure of the Complex of PDZ-RhoGEF DH/PH domains with GTP-gamma-S Activated RhoA Descriptor: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, MAGNESIUM ION, Rho guanine nucleotide exchange factor 11, ... Authors: Chen, Z, Sternweis, P.C, Sprang, S.R. Deposit date: 2009-12-07 Release date: 2010-04-28 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Activated RhoA binds to the pleckstrin homology (PH) domain of PDZ-RhoGEF, a potential site for autoregulation. J.Biol.Chem., 285, 2010
3KY9	Autoinhibited Vav1 Descriptor: Proto-oncogene vav, ZINC ION Authors: Tomchick, D.R, Rosen, M.K, Machius, M, Yu, B. Deposit date: 2009-12-04 Release date: 2010-02-23 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (2.731 Å) Cite: Structural and Energetic Mechanisms of Cooperative Autoinhibition and Activation of Vav1 Cell(Cambridge,Mass.), 140, 2010
3KSY	Crystal structure of the Histone domain, DH-PH unit, and catalytic unit of the Ras activator Son of Sevenless (SOS) Descriptor: Son of sevenless homolog 1 Authors: Gureasko, J, Kuchment, O, Kuriyan, J. Deposit date: 2009-11-24 Release date: 2010-02-16 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (3.178 Å) Cite: Role of the histone domain in the autoinhibition and activation of the Ras activator Son of Sevenless. Proc.Natl.Acad.Sci.USA, 107, 2010
3MPX	Crystal structure of the DH and PH-1 domains of human FGD5 Descriptor: FYVE, RhoGEF and PH domain-containing protein 5, UNKNOWN ATOM OR ION Authors: Shen, Y, Nedyalkova, L, Tong, Y, Tempel, W, Crombet, L, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC) Deposit date: 2010-04-27 Release date: 2010-06-23 Last modified: 2017-11-08 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Crystal structure of the DH and PH-1 domains of human FGD5 TO BE PUBLISHED
5QQN	PanDDA analysis group deposition -- Crystal Structure of Kalirin/Rac1 in complex with MolPort-010-382-606 Descriptor: 1,2-ETHANEDIOL, Kalirin, N-cyclopropyl-2-(4-{[(5-methyl-1,2-oxazol-3-yl)carbamoyl]amino}-1H-pyrazol-1-yl)acetamide, ... Authors: Gray, J.L, Krojer, T, Talon, R, Douangamath, A, Jimenez Antunez, C, Bountra, C, Arrowsmith, C.H, Edwards, A, Brennan, P.E, von Delft, F. Deposit date: 2019-05-03 Release date: 2019-12-18 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (2.26 Å) Cite: PanDDA analysis group deposition To Be Published
5QQE	PanDDA analysis group deposition -- Crystal Structure of Kalirin/Rac1 in complex with MolPort-009-531-494 Descriptor: 1,2-ETHANEDIOL, Kalirin, N-(5-methyl-1,2-oxazol-3-yl)-N'-[(3S)-4,4,4-trifluoro-3-hydroxy-3-(5-methylfuran-2-yl)butyl]urea, ... Authors: Gray, J.L, Krojer, T, Talon, R, Douangamath, A, Jimenez Antunez, C, Bountra, C, Arrowsmith, C.H, Edwards, A, Brennan, P.E, von Delft, F. Deposit date: 2019-05-03 Release date: 2019-12-18 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.95 Å) Cite: PanDDA analysis group deposition To Be Published
5QQK	PanDDA analysis group deposition -- Crystal Structure of Kalirin/Rac1 in complex with MolPort-009-359-835 Descriptor: 1,2-ETHANEDIOL, Kalirin, N-{1-[2-(diethylamino)ethyl]-1H-indol-5-yl}-N'-(5-methyl-1,2-oxazol-3-yl)urea, ... Authors: Gray, J.L, Krojer, T, Talon, R, Douangamath, A, Jimenez Antunez, C, Bountra, C, Arrowsmith, C.H, Edwards, A, Brennan, P.E, von Delft, F. Deposit date: 2019-05-03 Release date: 2019-12-18 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (2.24 Å) Cite: PanDDA analysis group deposition To Be Published
5QQG	PanDDA analysis group deposition -- Crystal Structure of Kalirin/Rac1 in complex with MolPort-009-541-216 Descriptor: 1,2-ETHANEDIOL, Kalirin, N-(5-methyl-1,2-oxazol-3-yl)-N'-[3-(4-phenylpiperazin-1-yl)propyl]urea, ... Authors: Gray, J.L, Krojer, T, Talon, R, Douangamath, A, Jimenez Antunez, C, Bountra, C, Arrowsmith, C.H, Edwards, A, Brennan, P.E, von Delft, F. Deposit date: 2019-05-03 Release date: 2019-12-18 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (2.23 Å) Cite: PanDDA analysis group deposition To Be Published
5QQF	PanDDA analysis group deposition -- Crystal Structure of Kalirin/Rac1 in complex with MolPort-004-412-710 Descriptor: 1,2-ETHANEDIOL, Kalirin, N-ethyl-N'-1,3-thiazol-2-ylurea, ... Authors: Gray, J.L, Krojer, T, Talon, R, Douangamath, A, Jimenez Antunez, C, Bountra, C, Arrowsmith, C.H, Edwards, A, Brennan, P.E, von Delft, F. Deposit date: 2019-05-03 Release date: 2019-12-18 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (2.26 Å) Cite: PanDDA analysis group deposition To Be Published

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