1XCG

Crystal Structure of Human RhoA in complex with DH/PH fragment of PDZRHOGEF

Summary for 1XCG

DescriptorRho guanine nucleotide exchange factor 11, Transforming protein RhoA (3 entities in total)
Functional Keywordsx-ray crystallography; regulation of rhoa gtpase; protein complex, signaling protein activator-signaling protein complex, signaling protein activator/signaling protein
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm O15085
Cell membrane; Lipid-anchor; Cytoplasmic side P61586
Total number of polymer chains4
Total molecular weight125875
Authors
Derewenda, U.,Oleksy, A.,Stevenson, A.S.,Korczynska, J.,Dauter, Z.,Somlyo, A.P.,Otlewski, J.,Somlyo, A.V.,Derewenda, Z.S. (deposition date: 2004-09-01, release date: 2004-12-14, Last modification date: 2011-07-13)
Primary citation
Derewenda, U.,Oleksy, A.,Stevenson, A.S.,Korczynska, J.,Dauter, Z.,Somlyo, A.P.,Otlewski, J.,Somlyo, A.V.,Derewenda, Z.S.
The crystal structure of RhoA in complex with the DH/PH fragment of PDZRhoGEF, an activator of the Ca(2+) sensitization pathway in smooth muscle
Structure, 12:1955-1965, 2004
PubMed: 15530360 (PDB entries with the same primary citation)
DOI: 10.1016/j.str.2004.09.003
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.5 Å)
NMR Information
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Structure validation

ClashscoreRamachandran outliersSidechain outliers90.9%15.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report