1KZ7

Crystal Structure of the DH/PH Fragment of Murine Dbs in Complex with the Placental Isoform of Human Cdc42

Summary for 1KZ7

Related1FOE 1KZG
DescriptorGUANINE NUCLEOTIDE EXCHANGE FACTOR DBS, CDC42 HOMOLOG (3 entities in total)
Functional Keywordsguanine nucleotide exchange factor (gef), small g-protein, signaling protein
Biological sourceMus musculus (house mouse)
More
Cellular locationCytoplasm Q64096
Cell membrane; Lipid-anchor; Cytoplasmic side (Potential) P60953
Total number of polymer chains4
Total molecular weight125304.42
Authors
Rossman, K.L.,Worthylake, D.K.,Snyder, J.T.,Siderovski, D.P.,Campbell, S.L.,Sondek, J. (deposition date: 2002-02-06, release date: 2002-03-20, Last modification date: 2011-07-13)
Primary citation
Rossman, K.L.,Worthylake, D.K.,Snyder, J.T.,Siderovski, D.P.,Campbell, S.L.,Sondek, J.
A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange.
EMBO J., 21:1315-1326, 2002
PubMed: 11889037 (PDB entries with the same primary citation)
DOI: 10.1093/emboj/21.6.1315
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.4 Å)
NMR Information
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.244110.6%2.0%7.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution