1KZ7

Crystal Structure of the DH/PH Fragment of Murine Dbs in Complex with the Placental Isoform of Human Cdc42

Summary for 1KZ7

Entry DOI	10.2210/pdb1kz7/pdb
Related	1FOE 1KZG
Descriptor	GUANINE NUCLEOTIDE EXCHANGE FACTOR DBS, CDC42 HOMOLOG (3 entities in total)
Functional Keywords	guanine nucleotide exchange factor (gef), small g-protein, signaling protein
Biological source	Mus musculus (house mouse) More
Cellular location	Cytoplasm: Q64096 Cell membrane; Lipid-anchor; Cytoplasmic side (Potential): P60953
Total number of polymer chains	4
Total formula weight	125304.42
Authors	Rossman, K.L.,Worthylake, D.K.,Snyder, J.T.,Siderovski, D.P.,Campbell, S.L.,Sondek, J. (deposition date: 2002-02-06, release date: 2002-03-20, Last modification date: 2021-10-27)
Primary citation	Rossman, K.L.,Worthylake, D.K.,Snyder, J.T.,Siderovski, D.P.,Campbell, S.L.,Sondek, J. A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange. EMBO J., 21:1315-1326, 2002 Cited by PubMed: 11889037 DOI: 10.1093/emboj/21.6.1315 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation