1KZ7

Crystal Structure of the DH/PH Fragment of Murine Dbs in Complex with the Placental Isoform of Human Cdc42

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C	GUANINE NUCLEOTIDE EXCHANGE FACTOR DBS	polymer	353	41710.1	2	UniProt (Q64096) Pfam (PF00621) Pfam (PF00169) In PDB	Mus musculus (house mouse)	DBL'S BIG SISTER, DBS
2	B, D	CDC42 HOMOLOG	polymer	188	20942.1	2	UniProt (P60953) Pfam (PF00071) In PDB	Homo sapiens (human)	G25K GTP-BINDING PROTEIN
3		water	water		18.0	323	Chemie (HOH)

Sequence modifications

A, C: 623 - 967 (UniProt: Q64096)

PDB	External Database	Details
Mse 622	-	SEE REMARK 999
Mse 637	Met 637	modified residue
Mse 662	Met 662	modified residue
Mse 667	Met 667	modified residue
Mse 686	Met 686	modified residue
Ile 696	Asn 696	SEE REMARK 999
Phe 697	Ile 697	SEE REMARK 999
Leu 698	Pro 698	SEE REMARK 999
Arg 699	Ala 699	SEE REMARK 999
Glu 700	Gly 700	SEE REMARK 999
Leu 701	Val 701	SEE REMARK 999
Mse 719	Met 719	modified residue
Mse 782	Met 782	modified residue
Mse 813	Met 813	modified residue
Mse 833	Met 833	modified residue
Mse 859	Met 859	modified residue
Mse 897	Met 897	modified residue
Ala 940	Glu 940	SEE REMARK 999
Glu 968	-	expression tag
His 969	-	expression tag
His 970	-	expression tag
His 971	-	expression tag
His 972	-	expression tag
His 973	-	expression tag
His 974	-	expression tag

B, D: 1 - 188 (UniProt: P60953)

PDB	External Database	Details
Ser 188	Cys 188	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	125304.4
All*	Total formula weight	125304.4

*Water molecules are not included.