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1KZ7

Crystal Structure of the DH/PH Fragment of Murine Dbs in Complex with the Placental Isoform of Human Cdc42

Functional Information from GO Data
ChainGOidnamespacecontents
A0005085molecular_functionguanyl-nucleotide exchange factor activity
A0035556biological_processintracellular signal transduction
B0000139cellular_componentGolgi membrane
B0000166molecular_functionnucleotide binding
B0000322cellular_componentstorage vacuole
B0002040biological_processsprouting angiogenesis
B0003015biological_processheart process
B0003161biological_processcardiac conduction system development
B0003253biological_processcardiac neural crest cell migration involved in outflow tract morphogenesis
B0003924molecular_functionGTPase activity
B0003925molecular_functionG protein activity
B0005515molecular_functionprotein binding
B0005525molecular_functionGTP binding
B0005737cellular_componentcytoplasm
B0005789cellular_componentendoplasmic reticulum membrane
B0005813cellular_componentcentrosome
B0005819cellular_componentspindle
B0005829cellular_componentcytosol
B0005856cellular_componentcytoskeleton
B0005886cellular_componentplasma membrane
B0005911cellular_componentcell-cell junction
B0005925cellular_componentfocal adhesion
B0006897biological_processendocytosis
B0006911biological_processphagocytosis, engulfment
B0007015biological_processactin filament organization
B0007030biological_processGolgi organization
B0007088biological_processregulation of mitotic nuclear division
B0007097biological_processnuclear migration
B0007163biological_processestablishment or maintenance of cell polarity
B0007229biological_processintegrin-mediated signaling pathway
B0007264biological_processsmall GTPase-mediated signal transduction
B0007399biological_processnervous system development
B0008104biological_processprotein localization
B0009653biological_processanatomical structure morphogenesis
B0010591biological_processregulation of lamellipodium assembly
B0010592biological_processpositive regulation of lamellipodium assembly
B0016020cellular_componentmembrane
B0016787molecular_functionhydrolase activity
B0017119cellular_componentGolgi transport complex
B0019901molecular_functionprotein kinase binding
B0021762biological_processsubstantia nigra development
B0030036biological_processactin cytoskeleton organization
B0030141cellular_componentsecretory granule
B0030154biological_processcell differentiation
B0030175cellular_componentfilopodium
B0030225biological_processmacrophage differentiation
B0030307biological_processpositive regulation of cell growth
B0030335biological_processpositive regulation of cell migration
B0030425cellular_componentdendrite
B0030496cellular_componentmidbody
B0030742molecular_functionGTP-dependent protein binding
B0031252cellular_componentcell leading edge
B0031256cellular_componentleading edge membrane
B0031274biological_processpositive regulation of pseudopodium assembly
B0031333biological_processnegative regulation of protein-containing complex assembly
B0031435molecular_functionmitogen-activated protein kinase kinase kinase binding
B0031996molecular_functionthioesterase binding
B0032427molecular_functionGBD domain binding
B0032467biological_processpositive regulation of cytokinesis
B0032488biological_processCdc42 protein signal transduction
B0032956biological_processregulation of actin cytoskeleton organization
B0032991cellular_componentprotein-containing complex
B0034191molecular_functionapolipoprotein A-I receptor binding
B0034329biological_processcell junction assembly
B0034332biological_processadherens junction organization
B0035050biological_processembryonic heart tube development
B0035088biological_processestablishment or maintenance of apical/basal cell polarity
B0036336biological_processdendritic cell migration
B0036464cellular_componentcytoplasmic ribonucleoprotein granule
B0038189biological_processneuropilin signaling pathway
B0042802molecular_functionidentical protein binding
B0042995cellular_componentcell projection
B0043005cellular_componentneuron projection
B0043025cellular_componentneuronal cell body
B0043197cellular_componentdendritic spine
B0043227cellular_componentmembrane-bounded organelle
B0043410biological_processpositive regulation of MAPK cascade
B0043525biological_processpositive regulation of neuron apoptotic process
B0044788biological_processmodulation by host of viral process
B0045177cellular_componentapical part of cell
B0045198biological_processestablishment of epithelial cell apical/basal polarity
B0045335cellular_componentphagocytic vesicle
B0045740biological_processpositive regulation of DNA replication
B0046330biological_processpositive regulation of JNK cascade
B0046847biological_processfilopodium assembly
B0048549biological_processpositive regulation of pinocytosis
B0048664biological_processneuron fate determination
B0051130biological_processpositive regulation of cellular component organization
B0051233cellular_componentspindle midzone
B0051489biological_processregulation of filopodium assembly
B0051491biological_processpositive regulation of filopodium assembly
B0051492biological_processregulation of stress fiber assembly
B0051496biological_processpositive regulation of stress fiber assembly
B0051647biological_processnucleus localization
B0051649biological_processestablishment of localization in cell
B0051683biological_processestablishment of Golgi localization
B0051835biological_processpositive regulation of synapse structural plasticity
B0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
B0051988biological_processregulation of attachment of spindle microtubules to kinetochore
B0060047biological_processheart contraction
B0060071biological_processWnt signaling pathway, planar cell polarity pathway
B0060501biological_processpositive regulation of epithelial cell proliferation involved in lung morphogenesis
B0060661biological_processsubmandibular salivary gland formation
B0060997biological_processdendritic spine morphogenesis
B0061630molecular_functionubiquitin protein ligase activity
B0070062cellular_componentextracellular exosome
B0071346biological_processcellular response to type II interferon
B0071944cellular_componentcell periphery
B0072384biological_processorganelle transport along microtubule
B0072686cellular_componentmitotic spindle
B0086101biological_processendothelin receptor signaling pathway involved in heart process
B0090135biological_processactin filament branching
B0090316biological_processpositive regulation of intracellular protein transport
B0098685cellular_componentSchaffer collateral - CA1 synapse
B0098978cellular_componentglutamatergic synapse
B0099159biological_processregulation of modification of postsynaptic structure
B0099175biological_processregulation of postsynapse organization
B0099563biological_processmodification of synaptic structure
B1900026biological_processpositive regulation of substrate adhesion-dependent cell spreading
C0005085molecular_functionguanyl-nucleotide exchange factor activity
C0035556biological_processintracellular signal transduction
D0000139cellular_componentGolgi membrane
D0000166molecular_functionnucleotide binding
D0000322cellular_componentstorage vacuole
D0002040biological_processsprouting angiogenesis
D0003015biological_processheart process
D0003161biological_processcardiac conduction system development
D0003253biological_processcardiac neural crest cell migration involved in outflow tract morphogenesis
D0003924molecular_functionGTPase activity
D0003925molecular_functionG protein activity
D0005515molecular_functionprotein binding
D0005525molecular_functionGTP binding
D0005737cellular_componentcytoplasm
D0005789cellular_componentendoplasmic reticulum membrane
D0005813cellular_componentcentrosome
D0005819cellular_componentspindle
D0005829cellular_componentcytosol
D0005856cellular_componentcytoskeleton
D0005886cellular_componentplasma membrane
D0005911cellular_componentcell-cell junction
D0005925cellular_componentfocal adhesion
D0006897biological_processendocytosis
D0006911biological_processphagocytosis, engulfment
D0007015biological_processactin filament organization
D0007030biological_processGolgi organization
D0007088biological_processregulation of mitotic nuclear division
D0007097biological_processnuclear migration
D0007163biological_processestablishment or maintenance of cell polarity
D0007229biological_processintegrin-mediated signaling pathway
D0007264biological_processsmall GTPase-mediated signal transduction
D0007399biological_processnervous system development
D0008104biological_processprotein localization
D0009653biological_processanatomical structure morphogenesis
D0010591biological_processregulation of lamellipodium assembly
D0010592biological_processpositive regulation of lamellipodium assembly
D0016020cellular_componentmembrane
D0016787molecular_functionhydrolase activity
D0017119cellular_componentGolgi transport complex
D0019901molecular_functionprotein kinase binding
D0021762biological_processsubstantia nigra development
D0030036biological_processactin cytoskeleton organization
D0030141cellular_componentsecretory granule
D0030154biological_processcell differentiation
D0030175cellular_componentfilopodium
D0030225biological_processmacrophage differentiation
D0030307biological_processpositive regulation of cell growth
D0030335biological_processpositive regulation of cell migration
D0030425cellular_componentdendrite
D0030496cellular_componentmidbody
D0030742molecular_functionGTP-dependent protein binding
D0031252cellular_componentcell leading edge
D0031256cellular_componentleading edge membrane
D0031274biological_processpositive regulation of pseudopodium assembly
D0031333biological_processnegative regulation of protein-containing complex assembly
D0031435molecular_functionmitogen-activated protein kinase kinase kinase binding
D0031996molecular_functionthioesterase binding
D0032427molecular_functionGBD domain binding
D0032467biological_processpositive regulation of cytokinesis
D0032488biological_processCdc42 protein signal transduction
D0032956biological_processregulation of actin cytoskeleton organization
D0032991cellular_componentprotein-containing complex
D0034191molecular_functionapolipoprotein A-I receptor binding
D0034329biological_processcell junction assembly
D0034332biological_processadherens junction organization
D0035050biological_processembryonic heart tube development
D0035088biological_processestablishment or maintenance of apical/basal cell polarity
D0036336biological_processdendritic cell migration
D0036464cellular_componentcytoplasmic ribonucleoprotein granule
D0038189biological_processneuropilin signaling pathway
D0042802molecular_functionidentical protein binding
D0042995cellular_componentcell projection
D0043005cellular_componentneuron projection
D0043025cellular_componentneuronal cell body
D0043197cellular_componentdendritic spine
D0043227cellular_componentmembrane-bounded organelle
D0043410biological_processpositive regulation of MAPK cascade
D0043525biological_processpositive regulation of neuron apoptotic process
D0044788biological_processmodulation by host of viral process
D0045177cellular_componentapical part of cell
D0045198biological_processestablishment of epithelial cell apical/basal polarity
D0045335cellular_componentphagocytic vesicle
D0045740biological_processpositive regulation of DNA replication
D0046330biological_processpositive regulation of JNK cascade
D0046847biological_processfilopodium assembly
D0048549biological_processpositive regulation of pinocytosis
D0048664biological_processneuron fate determination
D0051130biological_processpositive regulation of cellular component organization
D0051233cellular_componentspindle midzone
D0051489biological_processregulation of filopodium assembly
D0051491biological_processpositive regulation of filopodium assembly
D0051492biological_processregulation of stress fiber assembly
D0051496biological_processpositive regulation of stress fiber assembly
D0051647biological_processnucleus localization
D0051649biological_processestablishment of localization in cell
D0051683biological_processestablishment of Golgi localization
D0051835biological_processpositive regulation of synapse structural plasticity
D0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
D0051988biological_processregulation of attachment of spindle microtubules to kinetochore
D0060047biological_processheart contraction
D0060071biological_processWnt signaling pathway, planar cell polarity pathway
D0060501biological_processpositive regulation of epithelial cell proliferation involved in lung morphogenesis
D0060661biological_processsubmandibular salivary gland formation
D0060997biological_processdendritic spine morphogenesis
D0061630molecular_functionubiquitin protein ligase activity
D0070062cellular_componentextracellular exosome
D0071346biological_processcellular response to type II interferon
D0071944cellular_componentcell periphery
D0072384biological_processorganelle transport along microtubule
D0072686cellular_componentmitotic spindle
D0086101biological_processendothelin receptor signaling pathway involved in heart process
D0090135biological_processactin filament branching
D0090316biological_processpositive regulation of intracellular protein transport
D0098685cellular_componentSchaffer collateral - CA1 synapse
D0098978cellular_componentglutamatergic synapse
D0099159biological_processregulation of modification of postsynaptic structure
D0099175biological_processregulation of postsynapse organization
D0099563biological_processmodification of synaptic structure
D1900026biological_processpositive regulation of substrate adhesion-dependent cell spreading
Functional Information from PROSITE/UniProt
site_idPS00741
Number of Residues26
DetailsDH_1 Dbl homology (DH) domain signature. LdsYLlkPVqrItKyqLlLkEMlkyS
ChainResidueDetails
ALEU761-SER786

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsBINDING:
ChainResidueDetails
BGLY10
BTHR115
DGLY1010
DTHR1115

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
BASP57
DASP1057

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: (Microbial infection) O-AMP-tyrosine; by Haemophilus IbpA; alternate => ECO:0000269|PubMed:19362538, ECO:0000269|PubMed:20622875
ChainResidueDetails
BTYR32
DTYR1032

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: (Microbial infection) O-AMP-threonine; by Vibrio VopS => ECO:0000269|PubMed:19039103
ChainResidueDetails
BTHR35
DTHR1035

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphotyrosine; by SRC => ECO:0000269|PubMed:14506284
ChainResidueDetails
BTYR64
DTYR1064

site_idSWS_FT_FI6
Number of Residues2
DetailsMOD_RES: Cysteine methyl ester => ECO:0000269|PubMed:10676816, ECO:0007744|PDB:1DOA
ChainResidueDetails
BSER188
DSER1188

site_idSWS_FT_FI7
Number of Residues2
DetailsLIPID: S-geranylgeranyl cysteine => ECO:0000269|PubMed:10676816, ECO:0007744|PDB:1DOA
ChainResidueDetails
BSER188
DSER1188

site_idSWS_FT_FI8
Number of Residues2
DetailsCARBOHYD: (Microbial infection) O-linked (GlcNAc) tyrosine; by Photorhabdus PAU_02230; alternate => ECO:0000269|PubMed:24141704
ChainResidueDetails
BTYR32
DTYR1032

site_idSWS_FT_FI9
Number of Residues2
DetailsCARBOHYD: (Microbial infection) O-linked (Glc) threonine; by C.difficile toxins TcdA and TcdB; alternate => ECO:0000269|PubMed:24905543, ECO:0000269|PubMed:7775453, ECO:0000269|PubMed:7777059
ChainResidueDetails
BTHR35
DTHR1035

217705

PDB entries from 2024-03-27

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