5HZK
Crystal structure of photoinhibitable Intersectin1 containing wildtype LOV2 domain in complex with Cdc42
Summary for 5HZK
Entry DOI | 10.2210/pdb5hzk/pdb |
Descriptor | Cell division control protein 42 homolog, Intersectin-1,NPH1-1,Intersectin-1, GUANOSINE-5'-DIPHOSPHATE, ... (4 entities in total) |
Functional Keywords | signaling protein, photoswitch, chimera, complex |
Biological source | Homo sapiens (Human) More |
Cellular location | Cell membrane ; Lipid-anchor ; Cytoplasmic side : P60953 Endomembrane system : Q15811 |
Total number of polymer chains | 4 |
Total formula weight | 160527.68 |
Authors | Tarnawski, M.,Dagliyan, O.,Chu, P.H.,Shirvanyants, D.,Dokholyan, N.V.,Hahn, K.M.,Schlichting, I. (deposition date: 2016-02-02, release date: 2016-12-21, Last modification date: 2024-01-10) |
Primary citation | Dagliyan, O.,Tarnawski, M.,Chu, P.H.,Shirvanyants, D.,Schlichting, I.,Dokholyan, N.V.,Hahn, K.M. Engineering extrinsic disorder to control protein activity in living cells. Science, 354:1441-1444, 2016 Cited by PubMed: 27980211DOI: 10.1126/science.aah3404 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.3 Å) |
Structure validation
Download full validation report