7KYZ
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4LPK
| Crystal Structure of K-Ras WT, GDP-bound | Descriptor: | CALCIUM ION, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Ostrem, J.M, Peters, U, Sos, M.L, Wells, J.A, Shokat, K.M. | Deposit date: | 2013-07-16 | Release date: | 2013-11-27 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature, 503, 2013
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4LUC
| Crystal Structure of small molecule disulfide 6 bound to K-Ras G12C | Descriptor: | CALCIUM ION, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Ostrem, J.M, Peters, U, Sos, M.L, Wells, J.A, Shokat, K.M. | Deposit date: | 2013-07-25 | Release date: | 2013-11-27 | Last modified: | 2017-11-15 | Method: | X-RAY DIFFRACTION (1.29 Å) | Cite: | K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature, 503, 2013
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4M1T
| Crystal Structure of small molecule vinylsulfonamide 14 covalently bound to K-Ras G12C | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, K-Ras GTPase, N-{1-[(2,4-dichlorophenoxy)acetyl]piperidin-4-yl}ethanesulfonamide | Authors: | Ostrem, J.M, Peters, U, Sos, M.L, Wells, J.A, Shokat, K.M. | Deposit date: | 2013-08-04 | Release date: | 2013-11-27 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.703 Å) | Cite: | K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature, 503, 2013
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4M1S
| Crystal Structure of small molecule vinylsulfonamide 13 covalently bound to K-Ras G12C | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, K-Ras GTPase, N-{1-[N-(2,4-dichlorophenyl)glycyl]piperidin-4-yl}ethanesulfonamide | Authors: | Ostrem, J.M, Peters, U, Sos, M.L, Wells, J.A, Shokat, K.M. | Deposit date: | 2013-08-04 | Release date: | 2013-11-27 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.552 Å) | Cite: | K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature, 503, 2013
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4LRW
| Crystal Structure of K-Ras G12C (cysteine-light), GDP-bound | Descriptor: | GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION | Authors: | Ostrem, J.M, Peters, U, Sos, M.L, Wells, J.A, Shokat, K.M. | Deposit date: | 2013-07-21 | Release date: | 2013-11-27 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.151 Å) | Cite: | K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature, 503, 2013
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4LV6
| Crystal Structure of small molecule disulfide 4 covalently bound to K-Ras G12C | Descriptor: | 1-[(2,4-dichlorophenoxy)acetyl]-N-(2-sulfanylethyl)piperidine-4-carboxamide, CALCIUM ION, GTPase KRas, ... | Authors: | Ostrem, J.M, Peters, U, Sos, M.L, Wells, J.A, Shokat, K.M. | Deposit date: | 2013-07-26 | Release date: | 2013-11-27 | Last modified: | 2017-11-15 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature, 503, 2013
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4M1O
| Crystal Structure of small molecule vinylsulfonamide 7 covalently bound to K-Ras G12C | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, K-Ras GTPase, N-(1-{[(5,7-dichloro-2,2-dimethyl-1,3-benzodioxol-4-yl)oxy]acetyl}piperidin-4-yl)ethanesulfonamide | Authors: | Ostrem, J.M, Peters, U, Sos, M.L, Wells, J.A, Shokat, K.M. | Deposit date: | 2013-08-03 | Release date: | 2013-11-27 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.571 Å) | Cite: | K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature, 503, 2013
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1X1S
| Crystal structure of M-Ras in complex with GppNHp | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Ras-related protein M-Ras | Authors: | Ye, M, Shima, F, Muraoka, S, Liao, J, Okamoto, H, Yamamoto, M, Tamura, A, Yagi, N, Ueki, T, Kataoka, T. | Deposit date: | 2005-04-13 | Release date: | 2005-07-26 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal Structure of M-Ras Reveals a GTP-bound "Off" State Conformation of Ras Family Small GTPases J.Biol.Chem., 280, 2005
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1WMS
| High resolution crystal structure of human Rab9 GTPase: a novel antiviral drug target | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, Ras-related protein Rab-9A | Authors: | Chen, L, DiGiammarino, E, Zhou, X.E, Wang, Y, Toh, D, Hodge, T.W, Meehan, E.J. | Deposit date: | 2004-07-16 | Release date: | 2004-09-14 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.25 Å) | Cite: | High resolution crystal structure of human Rab9 GTPase: A novel antiviral drug target J.Biol.Chem., 279, 2004
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1X3S
| Crystal structure of human Rab18 in complex with Gppnhp | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Ras-related protein Rab-18 | Authors: | Kukimoto-Niino, M, Murayama, K, Chen, L, Liu, Z.J, Wang, B.C, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2005-05-10 | Release date: | 2005-11-10 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.32 Å) | Cite: | Crystal structure of human Rab18 in complex with Gppnhp To be Published
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1X1R
| Crystal structure of M-Ras in complex with GDP | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Ras-related protein M-Ras | Authors: | Ye, M, Shima, F, Muraoka, S, Liao, J, Okamoto, H, Yamamoto, M, Tamura, A, Yagi, N, Ueki, T, Kataoka, T. | Deposit date: | 2005-04-12 | Release date: | 2005-07-26 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Crystal Structure of M-Ras Reveals a GTP-bound "Off" State Conformation of Ras Family Small GTPases J.Biol.Chem., 280, 2005
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1XCM
| Crystal structure of the GppNHp-bound H-Ras G60A mutant | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Transforming protein p21/H-Ras-1 | Authors: | Ford, B, Nassar, N. | Deposit date: | 2004-09-02 | Release date: | 2005-05-10 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.84 Å) | Cite: | Crystal structure of the GppNHp-bound form of the RasG60A mutant To be Published
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1XTR
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1YU9
| GppNHp-Bound Rab4A | Descriptor: | GTP-binding protein, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... | Authors: | Eathiraj, S, Pan, X, Ritacco, C, Lambright, D.G. | Deposit date: | 2005-02-13 | Release date: | 2005-07-26 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.07 Å) | Cite: | Structural basis of family-wide Rab GTPase recognition by rabenosyn-5. Nature, 436, 2005
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1YZK
| GppNHp bound Rab11 GTPase | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Ras-related protein Rab-11A | Authors: | Eathiraj, S, Pan, X, Ritacco, C, Lambright, D.G. | Deposit date: | 2005-02-28 | Release date: | 2005-07-26 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural basis of family-wide Rab GTPase recognition by rabenosyn-5. Nature, 436, 2005
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1YZU
| GppNHp-Bound Rab21 GTPase at 2.50 A Resolution | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Ras-related protein Rab-21 | Authors: | Eathiraj, S, Pan, X, Ritacco, C, Lambright, D.G. | Deposit date: | 2005-02-28 | Release date: | 2005-07-26 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural basis of family-wide Rab GTPase recognition by rabenosyn-5. Nature, 436, 2005
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1Z0A
| GDP-Bound Rab2A GTPase | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Ras-related protein Rab-2A | Authors: | Eathiraj, S, Pan, X, Ritacco, C, Lambright, D.G. | Deposit date: | 2005-03-01 | Release date: | 2005-07-26 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.12 Å) | Cite: | Structural basis of family-wide Rab GTPase recognition by rabenosyn-5. Nature, 436, 2005
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1YZN
| GppNHp-Bound Ypt1p GTPase | Descriptor: | GTP-binding protein YPT1, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | Authors: | Eathiraj, S, Pan, X, Ritacco, C, Lambright, D.G. | Deposit date: | 2005-02-28 | Release date: | 2005-07-26 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.06 Å) | Cite: | Structural basis of family-wide Rab GTPase recognition by rabenosyn-5. Nature, 436, 2005
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1ZC3
| Crystal structure of the Ral-binding domain of Exo84 in complex with the active RalA | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Ras-related protein Ral-A, ... | Authors: | Jin, R, Junutula, J.R, Matern, H.T, Ervin, K.E, Scheller, R.H, Brunger, A.T. | Deposit date: | 2005-04-10 | Release date: | 2005-06-14 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Exo84 and Sec5 are competitive regulatory Sec6/8 effectors to the RalA GTPase. Embo J., 24, 2005
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1Z08
| GppNHp-Bound Rab21 Q53G mutant GTPase | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Ras-related protein Rab-21 | Authors: | Eathiraj, S, Pan, X, Ritacco, C, Lambright, D.G. | Deposit date: | 2005-03-01 | Release date: | 2005-07-26 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural basis of family-wide Rab GTPase recognition by rabenosyn-5. Nature, 436, 2005
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1ZC4
| Crystal structure of the Ral-binding domain of Exo84 in complex with the active RalA | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Ras-related protein Ral-A, ... | Authors: | Jin, R, Junutula, J.R, Matern, H.T, Ervin, K.E, Scheller, R.H, Brunger, A.T. | Deposit date: | 2005-04-10 | Release date: | 2005-06-14 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Exo84 and Sec5 are competitive regulatory Sec6/8 effectors to the RalA GTPase. Embo J., 24, 2005
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1Z07
| GppNHp-Bound Rab5c G55Q mutant GTPase | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Ras-related protein Rab-5C | Authors: | Eathiraj, S, Pan, X, Ritacco, C, Lambright, D.G. | Deposit date: | 2005-03-01 | Release date: | 2005-07-26 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.81 Å) | Cite: | Structural basis of family-wide Rab GTPase recognition by rabenosyn-5. Nature, 436, 2005
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1YZL
| GppNHp-Bound Rab9 GTPase | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Ras-related protein Rab-9A | Authors: | Eathiraj, S, Pan, X, Ritacco, C, Lambright, D.G. | Deposit date: | 2005-02-28 | Release date: | 2005-07-26 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Structural basis of family-wide Rab GTPase recognition by rabenosyn-5. Nature, 436, 2005
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1Z0I
| GDP-Bound Rab21 GTPase | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Ras-related protein Rab-21 | Authors: | Eathiraj, S, Pan, X, Ritacco, C, Lambright, D.G. | Deposit date: | 2005-03-01 | Release date: | 2005-07-26 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.33 Å) | Cite: | Structural basis of family-wide Rab GTPase recognition by rabenosyn-5. Nature, 436, 2005
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