6E6F
KRAS G13D bound to GppNHp (K13GNP)
Summary for 6E6F
| Entry DOI | 10.2210/pdb6e6f/pdb |
| Related | 6DZH 6E6C 6E6G 6E6H 6E6P |
| Descriptor | GTPase KRas, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, MAGNESIUM ION, ... (4 entities in total) |
| Functional Keywords | oncogene, ras, p21, signaling protein |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 2 |
| Total formula weight | 38953.34 |
| Authors | Johnson, C.W.,Mattos, C. (deposition date: 2018-07-24, release date: 2019-07-31, Last modification date: 2024-03-13) |
| Primary citation | Johnson, C.W.,Lin, Y.J.,Reid, D.,Parker, J.,Pavlopoulos, S.,Dischinger, P.,Graveel, C.,Aguirre, A.J.,Steensma, M.,Haigis, K.M.,Mattos, C. Isoform-Specific Destabilization of the Active Site Reveals a Molecular Mechanism of Intrinsic Activation of KRas G13D. Cell Rep, 28:1538-1550.e7, 2019 Cited by PubMed: 31390567DOI: 10.1016/j.celrep.2019.07.026 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (3.401 Å) |
Structure validation
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