5YXZ
Co-crystal Structure of KRAS (G12C) covalently bound with Quinazoline based inhibitor JBI484
Summary for 5YXZ
Entry DOI | 10.2210/pdb5yxz/pdb |
Descriptor | GTPase KRas, MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE, ... (6 entities in total) |
Functional Keywords | kras, g12c, transferase |
Biological source | Homo sapiens (Human) |
Cellular location | Cell membrane ; Lipid-anchor ; Cytoplasmic side : P01116 |
Total number of polymer chains | 1 |
Total formula weight | 20299.21 |
Authors | Swaminathan, S.,Thakur, M.K.,Kandan, S.,Gautam, A.,Kanavalli, M.,Simhadri, P.,Gosu, R. (deposition date: 2017-12-07, release date: 2018-04-18, Last modification date: 2023-11-22) |
Primary citation | Swaminathan, S.,Thakur, M.K.,Kandan, S.,Gautam, A.,Kanavalli, M.,Simhadri, P.,Gosu, R. Co-crystal Structure of KRAS (G12C) covalently bound with Quinazoline based inhibitor JBI484 To Be Published, |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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