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5YXZ

Co-crystal Structure of KRAS (G12C) covalently bound with Quinazoline based inhibitor JBI484

Functional Information from GO Data
ChainGOidnamespacecontents
A0003924molecular_functionGTPase activity
A0005525molecular_functionGTP binding
A0007165biological_processsignal transduction
A0016020cellular_componentmembrane
Functional Information from PDB Data
site_idAC1
Number of Residues6
Detailsbinding site for residue MG A 201
ChainResidue
ASER17
AGDP202
AHOH309
AHOH328
AHOH341
AHOH348

site_idAC2
Number of Residues25
Detailsbinding site for residue GDP A 202
ChainResidue
ALYS16
ASER17
AALA18
APHE28
AASP30
AASN116
ALYS117
AASP119
ALEU120
ASER145
AALA146
ALYS147
AMG201
A94C203
AHOH309
AHOH328
AHOH333
AHOH338
AHOH341
AHOH373
AHOH389
AHOH428
AGLY13
AVAL14
AGLY15

site_idAC3
Number of Residues17
Detailsbinding site for residue 94C A 203
ChainResidue
AVAL9
AGLY10
ACYS12
ALYS16
APRO34
ATHR58
AALA59
AGLY60
AGLU62
AARG68
AMET72
AHIS95
ATYR96
AGLN99
AASP105
AGDP202
AHOH394

site_idAC4
Number of Residues7
Detailsbinding site for residue EDO A 204
ChainResidue
ACYS12
AGLY13
AVAL14
AALA83
AASN86
ALYS169
AHOH327

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:22431598, ECO:0000269|PubMed:22566140
ChainResidueDetails
AGLY10
AVAL29
AALA59
AASN116

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: N-acetylmethionine; in GTPase KRas; alternate => ECO:0000269|Ref.17
ChainResidueDetails
AMET1

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: N-acetylthreonine; in GTPase KRas, N-terminally processed => ECO:0000269|Ref.17
ChainResidueDetails
ATHR2

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: N6-acetyllysine => ECO:0000269|PubMed:22711838
ChainResidueDetails
ALYS104

site_idSWS_FT_FI5
Number of Residues1
DetailsCARBOHYD: (Microbial infection) O-linked (Glc) threonine; by P.sordellii toxin TcsL => ECO:0000269|PubMed:19744486
ChainResidueDetails
ATHR35

219140

PDB entries from 2024-05-01

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