6BOF

Crystal structure of KRAS A146T-GDP demonstrating open switch 1 conformation

Summary for 6BOF

• Entry DOI: 10.2210/pdb6bof/pdb
• Descriptor: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE (3 entities in total)
• Functional Keywords: hydrolase, small gtpase, signal transduction, gdp binding
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 39227.58

Authors

Bera, A.K.,Yan, W.,Westover, K.D. (deposition date: 2017-11-20, release date: 2019-05-22, Last modification date: 2023-10-04)

• Primary citation: Poulin, E.J.,Bera, A.K.,Lu, J.,Lin, Y.J.,Strasser, S.D.,Paulo, J.A.,Huang, T.Q.,Morales, C.,Yan, W.,Cook, J.,Nowak, J.A.,Brubaker, D.K.,Joughin, B.A.,Johnson, C.W.,DeStefanis, R.A.,Ghazi, P.C.,Gondi, S.,Wales, T.E.,Iacob, R.E.,Bogdanova, L.,Gierut, J.J.,Li, Y.,Engen, J.R.,Perez-Mancera, P.A.,Braun, B.S.,Gygi, S.P.,Lauffenburger, D.A.,Westover, K.D.,Haigis, K.M.; Tissue-Specific Oncogenic Activity of KRASA146T.; Cancer Discov, 9:738-755, 2019; PubMed: 30952657; DOI: 10.1158/2159-8290.CD-18-1220

Experimental method

X-RAY DIFFRACTION (1.401 Å)