5ZC6
Solution structure of H-RasT35S mutant protein in complex with KBFM123
Summary for 5ZC6
Entry DOI | 10.2210/pdb5zc6/pdb |
Related | 2LCF 2LWI |
NMR Information | BMRB: 36166 |
Descriptor | GTPase HRas, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, 3-oxidanyl-~{N}-[[(2~{R})-oxolan-2-yl]methyl]naphthalene-2-carboxamide, ... (4 entities in total) |
Functional Keywords | inhibitor, complex, cancer, small gtpases, oncoprotein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 19678.98 |
Authors | Matsumoto, S.,Hayashi, Y.,Hiraga, T.,Matsuo, K.,Kataoka, T. (deposition date: 2018-02-15, release date: 2018-09-12, Last modification date: 2024-05-01) |
Primary citation | Matsumoto, S.,Hiraga, T.,Hayashi, Y.,Yoshikawa, Y.,Tsuda, C.,Araki, M.,Neya, M.,Shima, F.,Kataoka, T. Molecular Basis for Allosteric Inhibition of GTP-Bound H-Ras Protein by a Small-Molecule Compound Carrying a Naphthalene Ring Biochemistry, 57:5350-5358, 2018 Cited by PubMed: 30141910DOI: 10.1021/acs.biochem.8b00680 PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
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