2LWI
Solution structure of H-RasT35S mutant protein in complex with Kobe2601
Summary for 2LWI
Entry DOI | 10.2210/pdb2lwi/pdb |
NMR Information | BMRB: 18629 |
Descriptor | GTPase HRas, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | ras, gtp-bound form, signaling protein-inhibitor complex, signaling protein/inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cell membrane. Isoform 2: Nucleus: P01112 |
Total number of polymer chains | 1 |
Total formula weight | 20285.52 |
Authors | Araki, M.,Tamura, A.,Shima, F.,Kataoka, T. (deposition date: 2012-08-01, release date: 2013-05-22, Last modification date: 2024-05-15) |
Primary citation | Shima, F.,Yoshikawa, Y.,Ye, M.,Araki, M.,Matsumoto, S.,Liao, J.,Hu, L.,Sugimoto, T.,Ijiri, Y.,Takeda, A.,Nishiyama, Y.,Sato, C.,Muraoka, S.,Tamura, A.,Osoda, T.,Tsuda, K.,Miyakawa, T.,Fukunishi, H.,Shimada, J.,Kumasaka, T.,Yamamoto, M.,Kataoka, T. In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction. Proc.Natl.Acad.Sci.USA, 110:8182-8187, 2013 Cited by PubMed: 23630290DOI: 10.1073/pnas.1217730110 PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
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