2LWI

Solution structure of H-RasT35S mutant protein in complex with Kobe2601

Summary for 2LWI

Entry DOI	10.2210/pdb2lwi/pdb
NMR Information	BMRB: 18629
Descriptor	GTPase HRas, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, MAGNESIUM ION, ... (5 entities in total)
Functional Keywords	ras, gtp-bound form, signaling protein-inhibitor complex, signaling protein/inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cell membrane. Isoform 2: Nucleus: P01112
Total number of polymer chains	1
Total formula weight	20285.52
Authors	Araki, M.,Tamura, A.,Shima, F.,Kataoka, T. (deposition date: 2012-08-01, release date: 2013-05-22, Last modification date: 2022-08-24)
Primary citation	Shima, F.,Yoshikawa, Y.,Ye, M.,Araki, M.,Matsumoto, S.,Liao, J.,Hu, L.,Sugimoto, T.,Ijiri, Y.,Takeda, A.,Nishiyama, Y.,Sato, C.,Muraoka, S.,Tamura, A.,Osoda, T.,Tsuda, K.,Miyakawa, T.,Fukunishi, H.,Shimada, J.,Kumasaka, T.,Yamamoto, M.,Kataoka, T. In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction. Proc.Natl.Acad.Sci.USA, 110:8182-8187, 2013 Cited by PubMed: 23630290 DOI: 10.1073/pnas.1217730110 PDB entries with the same primary citation
Experimental method	SOLUTION NMR

Structure validation