Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

7PKS
DownloadVisualize
BU of 7pks by Molmil
Structural basis of Integrator-mediated transcription regulation
Descriptor: DNA Template, DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, ...
Authors:Fianu, I, Chen, Y, Dienemann, C, Cramer, P.
Deposit date:2021-08-26
Release date:2021-12-08
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structural basis of Integrator-mediated transcription regulation.
Science, 374, 2021
2NYM
DownloadVisualize
BU of 2nym by Molmil
Crystal Structure of Protein Phosphatase 2A (PP2A) with C-terminus truncated catalytic subunit
Descriptor: MANGANESE (II) ION, Protein phosphatase 2, Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform, ...
Authors:Chen, Y, Xing, Y, Xu, Y, Chao, Y, Lin, Z, Jeffrey, P.D, Shi, Y.
Deposit date:2006-11-21
Release date:2006-12-12
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Structure of the Protein Phosphatase 2A Holoenzyme.
Cell(Cambridge,Mass.), 127, 2006
7N6G
DownloadVisualize
BU of 7n6g by Molmil
C1 of central pair
Descriptor: CPC1, Calmodulin, DPY30, ...
Authors:Han, L, Zhang, K.
Deposit date:2021-06-08
Release date:2022-05-18
Last modified:2022-06-01
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Cryo-EM structure of an active central apparatus.
Nat.Struct.Mol.Biol., 29, 2022
6NTS
DownloadVisualize
BU of 6nts by Molmil
Protein Phosphatase 2A (Aalpha-B56alpha-Calpha) holoenzyme in complex with a Small Molecule Activator of PP2A (SMAP)
Descriptor: MANGANESE (II) ION, N-[(1R,2R,3S)-2-hydroxy-3-(10H-phenoxazin-10-yl)cyclohexyl]-4-(trifluoromethoxy)benzene-1-sulfonamide, Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform, ...
Authors:Huang, W, Taylor, D.
Deposit date:2019-01-30
Release date:2020-05-06
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (3.63 Å)
Cite:Selective PP2A Enhancement through Biased Heterotrimer Stabilization.
Cell, 181, 2020
5I8R
DownloadVisualize
BU of 5i8r by Molmil
aSMase with zinc
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Sphingomyelin phosphodiesterase, ...
Authors:Zhou, Y.F, Wei, R.R.
Deposit date:2016-02-19
Release date:2016-09-07
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.646 Å)
Cite:Human acid sphingomyelinase structures provide insight to molecular basis of Niemann-Pick disease.
Nat Commun, 7, 2016
7Z03
DownloadVisualize
BU of 7z03 by Molmil
Endonuclease state of the E. coli Mre11-Rad50 (SbcCD) head complex bound to ADP and extended dsDNA
Descriptor: ADENOSINE-5'-DIPHOSPHATE, DNA (39-MER), MAGNESIUM ION, ...
Authors:Gut, F, Kaeshammer, L, Lammens, K, Bartho, J, van de Logt, E, Kessler, B, Hopfner, K.P.
Deposit date:2022-02-21
Release date:2022-08-17
Last modified:2022-09-28
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Structural mechanism of endonucleolytic processing of blocked DNA ends and hairpins by Mre11-Rad50.
Mol.Cell, 82, 2022
8RBZ
DownloadVisualize
BU of 8rbz by Molmil
Structure of Integrator-PP2A-SOSS-CTD post-termination complex
Descriptor: DNA-directed RNA polymerase subunit, DSS1, Integrator complex subunit 1, ...
Authors:Fianu, I, Ochmann, M, Walshe, J.L, Cramer, P.
Deposit date:2023-12-05
Release date:2024-02-07
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Structural basis of Integrator-dependent RNA polymerase II termination.
Nature, 629, 2024
6VCA
DownloadVisualize
BU of 6vca by Molmil
TB38 complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5'-nucleotidase, ...
Authors:Zhou, Y.F, Lord, D.M.
Deposit date:2019-12-20
Release date:2020-11-11
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.73 Å)
Cite:A highly potent CD73 biparatopic antibody blocks organization of the enzyme active site through dual mechanisms.
J.Biol.Chem., 295, 2020
6T8H
DownloadVisualize
BU of 6t8h by Molmil
Cryo-EM structure of the DNA-bound PolD-PCNA processive complex from P. abyssi
Descriptor: DNA polymerase II small subunit, DNA polymerase sliding clamp, DNA primer, ...
Authors:Madru, C, Raia, P, Hugonneau Beaufet, I, Pehau-Arnaudet, G, England, P, Lindhal, E, Delarue, M, Carroni, M, Sauguet, L.
Deposit date:2019-10-24
Release date:2020-03-04
Last modified:2020-04-08
Method:ELECTRON MICROSCOPY (3.77 Å)
Cite:Structural basis for the increased processivity of D-family DNA polymerases in complex with PCNA.
Nat Commun, 11, 2020
7SQC
DownloadVisualize
BU of 7sqc by Molmil
Ciliary C1 central pair apparatus isolated from Chlamydomonas reinhardtii
Descriptor: ADENOSINE-5'-DIPHOSPHATE, CPC1, Calmodulin, ...
Authors:Gui, M, Wang, X, Dutcher, S.K, Brown, A, Zhang, R.
Deposit date:2021-11-05
Release date:2022-04-13
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Ciliary central apparatus structure reveals mechanisms of microtubule patterning.
Nat.Struct.Mol.Biol., 29, 2022
8GFT
DownloadVisualize
BU of 8gft by Molmil
Hsp90 provides platform for CRaf dephosphorylation by PP5
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Heat shock protein HSP 90-beta, ...
Authors:Jaime-Garza, M, Nowotny, C.A, Coutandin, D, Wang, F, Tabios, M, Agard, D.A.
Deposit date:2023-03-08
Release date:2023-05-03
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Hsp90 provides a platform for kinase dephosphorylation by PP5.
Nat Commun, 14, 2023
5W0W
DownloadVisualize
BU of 5w0w by Molmil
Crystal structure of Protein Phosphatase 2A bound to TIPRL
Descriptor: MANGANESE (II) ION, Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform, ...
Authors:Wu, C, Zheng, A, Li, J, Satyshur, K, Xing, Y.
Deposit date:2017-06-01
Release date:2018-01-17
Last modified:2020-01-01
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:Methylation-regulated decommissioning of multimeric PP2A complexes.
Nat Commun, 8, 2017
2NYL
DownloadVisualize
BU of 2nyl by Molmil
Crystal structure of Protein Phosphatase 2A (PP2A) holoenzyme with the catalytic subunit carboxyl terminus truncated
Descriptor: MANGANESE (II) ION, Protein phosphatase 2, regulatory subunit A (PR 65), ...
Authors:Xing, Y, Xu, Y, Chen, Y, Chao, Y, Lin, Z, Shi, Y.
Deposit date:2006-11-20
Release date:2006-12-12
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:Structure of the Protein Phosphatase 2A Holoenzyme.
Cell(Cambridge,Mass.), 127, 2006
7ZR5
DownloadVisualize
BU of 7zr5 by Molmil
CryoEM structure of HSP90-CDC37-BRAF(V600E)-PP5(closed) complex
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Heat shock protein HSP 90-beta, Hsp90 co-chaperone Cdc37, ...
Authors:Oberoi, J, Pearl, L.H.
Deposit date:2022-05-03
Release date:2022-12-14
Last modified:2022-12-21
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:HSP90-CDC37-PP5 forms a structural platform for kinase dephosphorylation.
Nat Commun, 13, 2022
7NZM
DownloadVisualize
BU of 7nzm by Molmil
Cryo-EM structure of pre-dephosphorylation complex of phosphorylated eIF2alpha with trapped holophosphatase (PP1A_D64A/PPP1R15A/G-actin/DNase I)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-TRIPHOSPHATE, Actin, ...
Authors:Yan, Y, Hardwick, S, Ron, D.
Deposit date:2021-03-24
Release date:2021-09-29
Last modified:2021-10-20
Method:ELECTRON MICROSCOPY (3.96 Å)
Cite:Higher-order phosphatase-substrate contacts terminate the integrated stress response.
Nat.Struct.Mol.Biol., 28, 2021
7YZP
DownloadVisualize
BU of 7yzp by Molmil
Hairpin-bound state of the E. coli Mre11-Rad50 (SbcCD) head complex bound to ADP and a DNA hairpin
Descriptor: ADENOSINE-5'-DIPHOSPHATE, DNA hairpin (59-MER), MAGNESIUM ION, ...
Authors:Gut, F, Kaeshammer, L, Lammens, K, Bartho, J, van de Logt, E, Kessler, B, Hopfner, K.P.
Deposit date:2022-02-21
Release date:2022-08-17
Last modified:2022-09-28
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Structural mechanism of endonucleolytic processing of blocked DNA ends and hairpins by Mre11-Rad50.
Mol.Cell, 82, 2022
7ZR1
DownloadVisualize
BU of 7zr1 by Molmil
Chaetomium thermophilum Mre11-Rad50-Nbs1 complex bound to ATPyS (composite structure)
Descriptor: DH domain-containing protein, Double-strand break repair protein, FHA domain-containing protein, ...
Authors:Bartho, J.D, Rotheneder, M, Stakyte, K, Lammens, K, Hopfner, K.P.
Deposit date:2022-05-03
Release date:2023-01-11
Last modified:2023-12-13
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Cryo-EM structure of the Mre11-Rad50-Nbs1 complex reveals the molecular mechanism of scaffolding functions.
Mol.Cell, 83, 2023
8RBX
DownloadVisualize
BU of 8rbx by Molmil
Structure of Integrator-PP2A bound to a paused RNA polymerase II-DSIF-NELF-nucleosome complex
Descriptor: DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit RPB11-a, DNA-directed RNA polymerase II subunit RPB3, ...
Authors:Fianu, I, Ochmann, M, Walshe, J.L, Cramer, P.
Deposit date:2023-12-05
Release date:2024-02-07
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Structural basis of Integrator-dependent RNA polymerase II termination.
Nature, 629, 2024
8BAH
DownloadVisualize
BU of 8bah by Molmil
Human Mre11-Nbs1 complex
Descriptor: Double-strand break repair protein MRE11, MANGANESE (II) ION, Nibrin
Authors:Bartho, J.D, Rotheneder, M, Stakyte, K, Lammens, K, Hopfner, K.P.
Deposit date:2022-10-11
Release date:2023-01-11
Last modified:2023-12-13
Method:ELECTRON MICROSCOPY (4.13 Å)
Cite:Cryo-EM structure of the Mre11-Rad50-Nbs1 complex reveals the molecular mechanism of scaffolding functions.
Mol.Cell, 83, 2023
7YCX
DownloadVisualize
BU of 7ycx by Molmil
The structure of INTAC-PEC complex
Descriptor: DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, DNA-directed RNA polymerase II subunit RPB1,DNA-directed RNA polymerase II subunit RPB1, ...
Authors:Zheng, H, Jin, Q, Wang, X, Qi, Y, Liu, W, Ren, Y, Zhao, D, Chen, F.X, Cheng, J, Chen, X, Xu, Y.
Deposit date:2022-07-02
Release date:2023-03-15
Last modified:2023-09-27
Method:ELECTRON MICROSCOPY (4.18 Å)
Cite:Structural basis of INTAC-regulated transcription.
Protein Cell, 14, 2023
6S85
DownloadVisualize
BU of 6s85 by Molmil
Cutting state of the E. coli Mre11-Rad50 (SbcCD) head complex bound to ADP and dsDNA.
Descriptor: ADENOSINE-5'-DIPHOSPHATE, DNA (31-MER), DNA (32-MER), ...
Authors:Kaeshammer, L, Saathoff, J.H, Gut, F, Bartho, J, Alt, A, Kessler, B, Lammens, K, Hopfner, K.P.
Deposit date:2019-07-08
Release date:2019-09-04
Last modified:2024-05-22
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Mechanism of DNA End Sensing and Processing by the Mre11-Rad50 Complex.
Mol.Cell, 76, 2019
7ZR6
DownloadVisualize
BU of 7zr6 by Molmil
CryoEM structure of HSP90-CDC37-BRAF(V600E)-PP5(open) complex
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Heat shock protein HSP 90-beta, Hsp90 co-chaperone Cdc37, ...
Authors:Oberoi, J, Pearl, L.H.
Deposit date:2022-05-03
Release date:2022-12-28
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:HSP90-CDC37-PP5 forms a structural platform for kinase dephosphorylation.
Nat Commun, 13, 2022
8B5R
DownloadVisualize
BU of 8b5r by Molmil
p97-p37-SPI substrate complex
Descriptor: I3 sequence being threaded through the p97 channel, Protein phosphatase 1 regulatory subunit 7, Serine/threonine-protein phosphatase PP1-gamma catalytic subunit, ...
Authors:van den Boom, J, Marini, G, Meyer, H, Saibil, H.
Deposit date:2022-09-24
Release date:2023-06-07
Last modified:2023-07-26
Method:ELECTRON MICROSCOPY (6.1 Å)
Cite:Structural basis of ubiquitin-independent PP1 complex disassembly by p97.
Embo J., 42, 2023
6HMS
DownloadVisualize
BU of 6hms by Molmil
Cryo-EM map of DNA polymerase D from Pyrococcus abyssi in complex with DNA
Descriptor: DNA (5'-D(*GP*AP*GP*AP*CP*GP*GP*GP*CP*CP*GP*CP*GP*TP*C)-3'), DNA (5'-D(P*TP*GP*AP*CP*GP*CP*GP*GP*CP*CP*CP*GP*TP*CP*TP*C)-3'), DNA polymerase II large subunit,DNA polymerase II large subunit, ...
Authors:Raia, P, Carroni, M, Sauguet, L.
Deposit date:2018-09-12
Release date:2019-01-30
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (7.1 Å)
Cite:Structure of the DP1-DP2 PolD complex bound with DNA and its implications for the evolutionary history of DNA and RNA polymerases.
PLoS Biol., 17, 2019
4V0U
DownloadVisualize
BU of 4v0u by Molmil
The crystal structure of ternary PP1G-PPP1R15B and G-actin complex
Descriptor: ACTIN, ALPHA SKELETAL MUSCLE, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Chen, R, Yan, Y, Casado, A.C, Ron, D, Read, R.J.
Deposit date:2014-09-18
Release date:2015-03-25
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (7.88 Å)
Cite:G-actin provides substrate-specificity to eukaryotic initiation factor 2 alpha holophosphatases.
Elife, 4, 2015

221051

數據於2024-06-12公開中

PDB statisticsPDBj update infoContact PDBjnumon