5I8R

aSMase with zinc

Summary for 5I8R

Entry DOI	10.2210/pdb5i8r/pdb
Related	5I81 5I85
Descriptor	Sphingomyelin phosphodiesterase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
Functional Keywords	acid sphingomyelinase, olipudase alfa, zinc, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	3
Total formula weight	201859.98
Authors	Zhou, Y.F.,Wei, R.R. (deposition date: 2016-02-19, release date: 2016-09-07, Last modification date: 2023-09-27)
Primary citation	Zhou, Y.F.,Metcalf, M.C.,Garman, S.C.,Edmunds, T.,Qiu, H.,Wei, R.R. Human acid sphingomyelinase structures provide insight to molecular basis of Niemann-Pick disease. Nat Commun, 7:13082-13082, 2016 Cited by PubMed: 27725636 DOI: 10.1038/ncomms13082 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.646 Å)

Structure validation