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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

5I8R

aSMase with zinc

Functional Information from GO Data
ChainGOidnamespacecontents
A0001778biological_processplasma membrane repair
A0004767molecular_functionsphingomyelin phosphodiesterase activity
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005764cellular_componentlysosome
A0005768cellular_componentendosome
A0005811cellular_componentlipid droplet
A0005886cellular_componentplasma membrane
A0006629biological_processlipid metabolic process
A0006684biological_processsphingomyelin metabolic process
A0006685biological_processsphingomyelin catabolic process
A0007165biological_processsignal transduction
A0007399biological_processnervous system development
A0008270molecular_functionzinc ion binding
A0009410biological_processresponse to xenobiotic stimulus
A0009615biological_processresponse to virus
A0010212biological_processresponse to ionizing radiation
A0016787molecular_functionhydrolase activity
A0016798molecular_functionhydrolase activity, acting on glycosyl bonds
A0023021biological_processtermination of signal transduction
A0034340biological_processresponse to type I interferon
A0034480molecular_functionphosphatidylcholine phospholipase C activity
A0034612biological_processresponse to tumor necrosis factor
A0034644biological_processcellular response to UV
A0036019cellular_componentendolysosome
A0042060biological_processwound healing
A0042220biological_processresponse to cocaine
A0042599cellular_componentlamellar body
A0043065biological_processpositive regulation of apoptotic process
A0043202cellular_componentlysosomal lumen
A0043409biological_processnegative regulation of MAPK cascade
A0045807biological_processpositive regulation of endocytosis
A0046479biological_processglycosphingolipid catabolic process
A0046513biological_processceramide biosynthetic process
A0046598biological_processpositive regulation of viral entry into host cell
A0046718biological_processsymbiont entry into host cell
A0046872molecular_functionmetal ion binding
A0061750molecular_functionacid sphingomyelin phosphodiesterase activity
A0070062cellular_componentextracellular exosome
A0070555biological_processresponse to interleukin-1
A0071277biological_processcellular response to calcium ion
B0001778biological_processplasma membrane repair
B0004767molecular_functionsphingomyelin phosphodiesterase activity
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005764cellular_componentlysosome
B0005768cellular_componentendosome
B0005811cellular_componentlipid droplet
B0005886cellular_componentplasma membrane
B0006629biological_processlipid metabolic process
B0006684biological_processsphingomyelin metabolic process
B0006685biological_processsphingomyelin catabolic process
B0007165biological_processsignal transduction
B0007399biological_processnervous system development
B0008270molecular_functionzinc ion binding
B0009410biological_processresponse to xenobiotic stimulus
B0009615biological_processresponse to virus
B0010212biological_processresponse to ionizing radiation
B0016787molecular_functionhydrolase activity
B0016798molecular_functionhydrolase activity, acting on glycosyl bonds
B0023021biological_processtermination of signal transduction
B0034340biological_processresponse to type I interferon
B0034480molecular_functionphosphatidylcholine phospholipase C activity
B0034612biological_processresponse to tumor necrosis factor
B0034644biological_processcellular response to UV
B0036019cellular_componentendolysosome
B0042060biological_processwound healing
B0042220biological_processresponse to cocaine
B0042599cellular_componentlamellar body
B0043065biological_processpositive regulation of apoptotic process
B0043202cellular_componentlysosomal lumen
B0043409biological_processnegative regulation of MAPK cascade
B0045807biological_processpositive regulation of endocytosis
B0046479biological_processglycosphingolipid catabolic process
B0046513biological_processceramide biosynthetic process
B0046598biological_processpositive regulation of viral entry into host cell
B0046718biological_processsymbiont entry into host cell
B0046872molecular_functionmetal ion binding
B0061750molecular_functionacid sphingomyelin phosphodiesterase activity
B0070062cellular_componentextracellular exosome
B0070555biological_processresponse to interleukin-1
B0071277biological_processcellular response to calcium ion
C0001778biological_processplasma membrane repair
C0004767molecular_functionsphingomyelin phosphodiesterase activity
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0005764cellular_componentlysosome
C0005768cellular_componentendosome
C0005811cellular_componentlipid droplet
C0005886cellular_componentplasma membrane
C0006629biological_processlipid metabolic process
C0006684biological_processsphingomyelin metabolic process
C0006685biological_processsphingomyelin catabolic process
C0007165biological_processsignal transduction
C0007399biological_processnervous system development
C0008270molecular_functionzinc ion binding
C0009410biological_processresponse to xenobiotic stimulus
C0009615biological_processresponse to virus
C0010212biological_processresponse to ionizing radiation
C0016787molecular_functionhydrolase activity
C0016798molecular_functionhydrolase activity, acting on glycosyl bonds
C0023021biological_processtermination of signal transduction
C0034340biological_processresponse to type I interferon
C0034480molecular_functionphosphatidylcholine phospholipase C activity
C0034612biological_processresponse to tumor necrosis factor
C0034644biological_processcellular response to UV
C0036019cellular_componentendolysosome
C0042060biological_processwound healing
C0042220biological_processresponse to cocaine
C0042599cellular_componentlamellar body
C0043065biological_processpositive regulation of apoptotic process
C0043202cellular_componentlysosomal lumen
C0043409biological_processnegative regulation of MAPK cascade
C0045807biological_processpositive regulation of endocytosis
C0046479biological_processglycosphingolipid catabolic process
C0046513biological_processceramide biosynthetic process
C0046598biological_processpositive regulation of viral entry into host cell
C0046718biological_processsymbiont entry into host cell
C0046872molecular_functionmetal ion binding
C0061750molecular_functionacid sphingomyelin phosphodiesterase activity
C0070062cellular_componentextracellular exosome
C0070555biological_processresponse to interleukin-1
C0071277biological_processcellular response to calcium ion
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues252
DetailsDomain: {"description":"Saposin B-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00415","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues21
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"27349982","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5I81","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5I85","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5I8R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5JG8","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues3
DetailsSite: {"description":"Cleavage; by CASP7","evidences":[{"source":"PubMed","id":"21157428","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues3
DetailsModified residue: {"description":"Phosphoserine; by PKC/PRKCD","evidences":[{"source":"PubMed","id":"17303575","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues12
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PROSITE-ProRule","id":"PRU00415","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"27349982","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9030779","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5I81","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5I85","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5I8R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5JG8","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues3
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PROSITE-ProRule","id":"PRU00415","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"27349982","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9030779","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5I81","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5I8R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5JG8","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues3
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"27349982","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5I81","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5I85","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5I8R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5JG8","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

247947

PDB entries from 2026-01-21

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