Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5I8R

aSMase with zinc

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001778	biological_process	plasma membrane repair
A	0004767	molecular_function	sphingomyelin phosphodiesterase activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005764	cellular_component	lysosome
A	0005768	cellular_component	endosome
A	0005811	cellular_component	lipid droplet
A	0005886	cellular_component	plasma membrane
A	0006629	biological_process	lipid metabolic process
A	0006672	biological_process	ceramide metabolic process
A	0006684	biological_process	sphingomyelin metabolic process
A	0006685	biological_process	sphingomyelin catabolic process
A	0007165	biological_process	signal transduction
A	0007399	biological_process	nervous system development
A	0008203	biological_process	cholesterol metabolic process
A	0008270	molecular_function	zinc ion binding
A	0009410	biological_process	response to xenobiotic stimulus
A	0009615	biological_process	response to virus
A	0010212	biological_process	response to ionizing radiation
A	0016787	molecular_function	hydrolase activity
A	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
A	0023021	biological_process	termination of signal transduction
A	0034340	biological_process	response to type I interferon
A	0034480	molecular_function	phosphatidylcholine phospholipase C activity
A	0034612	biological_process	response to tumor necrosis factor
A	0034644	biological_process	cellular response to UV
A	0035307	biological_process	positive regulation of protein dephosphorylation
A	0036019	cellular_component	endolysosome
A	0042060	biological_process	wound healing
A	0042220	biological_process	response to cocaine
A	0042599	cellular_component	lamellar body
A	0043065	biological_process	positive regulation of apoptotic process
A	0043202	cellular_component	lysosomal lumen
A	0043407	biological_process	negative regulation of MAP kinase activity
A	0045807	biological_process	positive regulation of endocytosis
A	0046479	biological_process	glycosphingolipid catabolic process
A	0046513	biological_process	ceramide biosynthetic process
A	0046598	biological_process	positive regulation of viral entry into host cell
A	0046718	biological_process	symbiont entry into host cell
A	0046872	molecular_function	metal ion binding
A	0061750	molecular_function	acid sphingomyelin phosphodiesterase activity
A	0070062	cellular_component	extracellular exosome
A	0070555	biological_process	response to interleukin-1
A	0071277	biological_process	cellular response to calcium ion
B	0001778	biological_process	plasma membrane repair
B	0004767	molecular_function	sphingomyelin phosphodiesterase activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005764	cellular_component	lysosome
B	0005768	cellular_component	endosome
B	0005811	cellular_component	lipid droplet
B	0005886	cellular_component	plasma membrane
B	0006629	biological_process	lipid metabolic process
B	0006672	biological_process	ceramide metabolic process
B	0006684	biological_process	sphingomyelin metabolic process
B	0006685	biological_process	sphingomyelin catabolic process
B	0007165	biological_process	signal transduction
B	0007399	biological_process	nervous system development
B	0008203	biological_process	cholesterol metabolic process
B	0008270	molecular_function	zinc ion binding
B	0009410	biological_process	response to xenobiotic stimulus
B	0009615	biological_process	response to virus
B	0010212	biological_process	response to ionizing radiation
B	0016787	molecular_function	hydrolase activity
B	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
B	0023021	biological_process	termination of signal transduction
B	0034340	biological_process	response to type I interferon
B	0034480	molecular_function	phosphatidylcholine phospholipase C activity
B	0034612	biological_process	response to tumor necrosis factor
B	0034644	biological_process	cellular response to UV
B	0035307	biological_process	positive regulation of protein dephosphorylation
B	0036019	cellular_component	endolysosome
B	0042060	biological_process	wound healing
B	0042220	biological_process	response to cocaine
B	0042599	cellular_component	lamellar body
B	0043065	biological_process	positive regulation of apoptotic process
B	0043202	cellular_component	lysosomal lumen
B	0043407	biological_process	negative regulation of MAP kinase activity
B	0045807	biological_process	positive regulation of endocytosis
B	0046479	biological_process	glycosphingolipid catabolic process
B	0046513	biological_process	ceramide biosynthetic process
B	0046598	biological_process	positive regulation of viral entry into host cell
B	0046718	biological_process	symbiont entry into host cell
B	0046872	molecular_function	metal ion binding
B	0061750	molecular_function	acid sphingomyelin phosphodiesterase activity
B	0070062	cellular_component	extracellular exosome
B	0070555	biological_process	response to interleukin-1
B	0071277	biological_process	cellular response to calcium ion
C	0001778	biological_process	plasma membrane repair
C	0004767	molecular_function	sphingomyelin phosphodiesterase activity
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005764	cellular_component	lysosome
C	0005768	cellular_component	endosome
C	0005811	cellular_component	lipid droplet
C	0005886	cellular_component	plasma membrane
C	0006629	biological_process	lipid metabolic process
C	0006672	biological_process	ceramide metabolic process
C	0006684	biological_process	sphingomyelin metabolic process
C	0006685	biological_process	sphingomyelin catabolic process
C	0007165	biological_process	signal transduction
C	0007399	biological_process	nervous system development
C	0008203	biological_process	cholesterol metabolic process
C	0008270	molecular_function	zinc ion binding
C	0009410	biological_process	response to xenobiotic stimulus
C	0009615	biological_process	response to virus
C	0010212	biological_process	response to ionizing radiation
C	0016787	molecular_function	hydrolase activity
C	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
C	0023021	biological_process	termination of signal transduction
C	0034340	biological_process	response to type I interferon
C	0034480	molecular_function	phosphatidylcholine phospholipase C activity
C	0034612	biological_process	response to tumor necrosis factor
C	0034644	biological_process	cellular response to UV
C	0035307	biological_process	positive regulation of protein dephosphorylation
C	0036019	cellular_component	endolysosome
C	0042060	biological_process	wound healing
C	0042220	biological_process	response to cocaine
C	0042599	cellular_component	lamellar body
C	0043065	biological_process	positive regulation of apoptotic process
C	0043202	cellular_component	lysosomal lumen
C	0043407	biological_process	negative regulation of MAP kinase activity
C	0045807	biological_process	positive regulation of endocytosis
C	0046479	biological_process	glycosphingolipid catabolic process
C	0046513	biological_process	ceramide biosynthetic process
C	0046598	biological_process	positive regulation of viral entry into host cell
C	0046718	biological_process	symbiont entry into host cell
C	0046872	molecular_function	metal ion binding
C	0061750	molecular_function	acid sphingomyelin phosphodiesterase activity
C	0070062	cellular_component	extracellular exosome
C	0070555	biological_process	response to interleukin-1
C	0071277	biological_process	cellular response to calcium ion

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	21
Details	BINDING: BINDING => ECO:0000269\|PubMed:27349982, ECO:0007744\|PDB:5I81, ECO:0007744\|PDB:5I85, ECO:0007744\|PDB:5I8R, ECO:0007744\|PDB:5JG8

Chain	Residue	Details
A	GLU320
A	PRO427
A	HIS459
A	ASP461
B	HIS208
B	ASP210
B	PRO280
B	GLU320
B	PRO427
B	HIS459
B	ASP461
C	HIS208
C	ASP210
C	PRO280
C	GLU320
C	PRO427
C	HIS459
C	ASP461
A	HIS208
A	ASP210
A	PRO280

site_id	SWS_FT_FI2
Number of Residues	3
Details	SITE: Cleavage; by CASP7 => ECO:0000269\|PubMed:21157428

Chain	Residue	Details
A	PRO253
B	PRO253
C	PRO253

site_id	SWS_FT_FI3
Number of Residues	3
Details	MOD_RES: Phosphoserine; by PKC/PRKCD => ECO:0000269\|PubMed:17303575

Chain	Residue	Details
A	VAL510
B	VAL510
C	VAL510

site_id	SWS_FT_FI4
Number of Residues	12
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255\|PROSITE-ProRule:PRU00415, ECO:0000269\|PubMed:27349982, ECO:0000269\|PubMed:9030779, ECO:0007744\|PDB:5I81, ECO:0007744\|PDB:5I85, ECO:0007744\|PDB:5I8R, ECO:0007744\|PDB:5JG8

Chain	Residue	Details
A	THR522
B	THR88
B	SER177
B	THR397
B	THR522
C	THR88
C	SER177
C	THR397
C	THR522
A	THR88
A	SER177
A	THR397

site_id	SWS_FT_FI5
Number of Residues	3
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255\|PROSITE-ProRule:PRU00415, ECO:0000269\|PubMed:27349982, ECO:0000269\|PubMed:9030779, ECO:0007744\|PDB:5I81, ECO:0007744\|PDB:5I8R, ECO:0007744\|PDB:5JG8

Chain	Residue	Details
A	SER337
B	SER337
C	SER337

site_id	SWS_FT_FI6
Number of Residues	3
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:27349982, ECO:0007744\|PDB:5I81, ECO:0007744\|PDB:5I85, ECO:0007744\|PDB:5I8R, ECO:0007744\|PDB:5JG8

Chain	Residue	Details
A	SER505
B	SER505
C	SER505

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)