6NTS

Protein Phosphatase 2A (Aalpha-B56alpha-Calpha) holoenzyme in complex with a Small Molecule Activator of PP2A (SMAP)

Summary for 6NTS

Entry DOI	10.2210/pdb6nts/pdb
EMDB information	0510
Descriptor	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform, Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform, ... (5 entities in total)
Functional Keywords	holoenzyme complex, phosphatase, activator, hydrolase-activator complex, hydrolase/activator
Biological source	Homo sapiens (Human) More
Total number of polymer chains	3
Total formula weight	157296.80
Authors	Huang, W.,Taylor, D. (deposition date: 2019-01-30, release date: 2020-05-06, Last modification date: 2023-11-15)
Primary citation	Leonard, D.,Huang, W.,Izadmehr, S.,O'Connor, C.M.,Wiredja, D.D.,Wang, Z.,Zaware, N.,Chen, Y.,Schlatzer, D.M.,Kiselar, J.,Vasireddi, N.,Schuchner, S.,Perl, A.L.,Galsky, M.D.,Xu, W.,Brautigan, D.L.,Ogris, E.,Taylor, D.J.,Narla, G. Selective PP2A Enhancement through Biased Heterotrimer Stabilization. Cell, 181:688-701.e16, 2020 Cited by PubMed: 32315618 DOI: 10.1016/j.cell.2020.03.038 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.63 Å)

Structure validation