6NTS
Protein Phosphatase 2A (Aalpha-B56alpha-Calpha) holoenzyme in complex with a Small Molecule Activator of PP2A (SMAP)
Summary for 6NTS
Entry DOI | 10.2210/pdb6nts/pdb |
EMDB information | 0510 |
Descriptor | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform, Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform, ... (5 entities in total) |
Functional Keywords | holoenzyme complex, phosphatase, activator, hydrolase-activator complex, hydrolase/activator |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 3 |
Total formula weight | 157296.80 |
Authors | Huang, W.,Taylor, D. (deposition date: 2019-01-30, release date: 2020-05-06, Last modification date: 2023-11-15) |
Primary citation | Leonard, D.,Huang, W.,Izadmehr, S.,O'Connor, C.M.,Wiredja, D.D.,Wang, Z.,Zaware, N.,Chen, Y.,Schlatzer, D.M.,Kiselar, J.,Vasireddi, N.,Schuchner, S.,Perl, A.L.,Galsky, M.D.,Xu, W.,Brautigan, D.L.,Ogris, E.,Taylor, D.J.,Narla, G. Selective PP2A Enhancement through Biased Heterotrimer Stabilization. Cell, 181:688-701.e16, 2020 Cited by PubMed: 32315618DOI: 10.1016/j.cell.2020.03.038 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.63 Å) |
Structure validation
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