6NTS
Protein Phosphatase 2A (Aalpha-B56alpha-Calpha) holoenzyme in complex with a Small Molecule Activator of PP2A (SMAP)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform | polymer | 589 | 65378.3 | 1 | UniProt (P30153) Pfam (PF02985) | Homo sapiens (Human) | Medium tumor antigen-associated 61 kDa protein,PP2A subunit A isoform PR65-alpha,PP2A subunit A isoform R1-alpha |
| 2 | B (B) | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform | polymer | 486 | 56266.6 | 1 | UniProt (Q15172) Pfam (PF01603) | Homo sapiens (Human) | PP2A B subunit isoform B'-alpha,PP2A B subunit isoform B56-alpha,PP2A B subunit isoform PR61-alpha,PR61alpha,PP2A B subunit isoform R5-alpha |
| 3 | C (C) | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform | polymer | 304 | 35021.5 | 1 | UniProt (P67775) Pfam (PF00149) | Homo sapiens (Human) | PP2A-alpha,Replication protein C,RP-C |
| 4 | D (A) | N-[(1R,2R,3S)-2-hydroxy-3-(10H-phenoxazin-10-yl)cyclohexyl]-4-(trifluoromethoxy)benzene-1-sulfonamide | non-polymer | 520.5 | 1 | Chemie (L2J) | |||
| 5 | E, F (C) | MANGANESE (II) ION | non-polymer | 54.9 | 2 | Chemie (MN) |
Sequence modifications
C: 1 - 306 (UniProt: P67775)
| PDB | External Database | Details |
|---|---|---|
| Asn 88 | Asp 88 | conflict |
| Tyr 307 | - | expression tag |
| Phe 308 | - | expression tag |
| Mll 309 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 156666.4 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 630.4 | |
| All* | Total formula weight | 157296.8 |
