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8R8P	Solution structure of SMN-CX bound to the RNA helix formed upon SMN2 exon7 5'-splice site recognition Descriptor: 2-(8-fluoranyl-2-methyl-imidazo[1,2-a]pyridin-6-yl)-6-(4-methylpiperazin-1-yl)quinazoline, RNA (5'-R(*AP*UP*AP*CP*(PSU)P*(PSU)P*AP*CP*CP*UP*G)-3'), RNA (5'-R(P*GP*GP*AP*GP*UP*AP*AP*GP*UP*CP*U)-3') Authors: Malard, F, Campagne, S. Deposit date: 2023-11-29 Release date: 2024-03-06 Last modified: 2024-05-22 Method: SOLID-STATE NMR Cite: The diversity of splicing modifiers acting on A-1 bulged 5'-splice sites reveals rules for rational drug design. Nucleic Acids Res., 52, 2024
4HFZ	Crystal Structure of an MDM2/P53 Peptide Complex Descriptor: Cellular tumor antigen p53, E3 ubiquitin-protein ligase Mdm2, SULFATE ION Authors: Anil, B, Riedinger, C, Endicott, J.A, Noble, M.E.M. Deposit date: 2012-10-05 Release date: 2013-07-31 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.694 Å) Cite: The structure of an MDM2-Nutlin-3a complex solved by the use of a validated MDM2 surface-entropy reduction mutant. Acta Crystallogr.,Sect.D, 69, 2013
8QFC	UFL1 E3 ligase bound 60S ribosome Descriptor: 60S ribosomal protein L10a, CDK5 regulatory subunit-associated protein 3, DDRGK domain-containing protein 1, ... Authors: Makhlouf, L, Zeqiraj, E, Kulathu, Y. Deposit date: 2023-09-04 Release date: 2024-02-21 Last modified: 2024-04-03 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: The UFM1 E3 ligase recognizes and releases 60S ribosomes from ER translocons. Nature, 627, 2024
8R63	Solution structure of branaplam bound to the RNA duplex formed upon 5'-splice site recognition Descriptor: 5-(1~{H}-pyrazol-4-yl)-2-[6-(2,2,6,6-tetramethylpiperidin-4-yl)oxypyridazin-3-yl]phenol, RNA (5'-R(*AP*UP*AP*CP*(PSU)P*(PSU)P*AP*CP*CP*UP*G)-3'), RNA (5'-R(P*GP*GP*AP*GP*UP*AP*AP*GP*UP*CP*U)-3') Authors: Malard, F, Campagne, S. Deposit date: 2023-11-20 Release date: 2024-03-06 Last modified: 2024-05-22 Method: SOLUTION NMR Cite: The diversity of splicing modifiers acting on A-1 bulged 5'-splice sites reveals rules for rational drug design. Nucleic Acids Res., 52, 2024
4IFI	Structure of human BRCA1 BRCT in complex with BAAT peptide Descriptor: ACETATE ION, BAAT peptide, Breast cancer type 1 susceptibility protein Authors: Liu, X, Ladias, J.A.A. Deposit date: 2012-12-14 Release date: 2013-10-30 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Structural Basis for the BRCA1 BRCT Interaction with the Proteins ATRIP and BAAT1. Biochemistry, 52, 2013
6EML	Cryo-EM structure of a late pre-40S ribosomal subunit from Saccharomyces cerevisiae Descriptor: 40S ribosomal protein S0-A, 40S ribosomal protein S1-A, 40S ribosomal protein S11-A, ... Authors: Heuer, A, Thomson, E, Schmidt, C, Berninghausen, O, Becker, T, Hurt, E, Beckmann, R. Deposit date: 2017-10-02 Release date: 2017-11-29 Last modified: 2024-05-08 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: Cryo-EM structure of a late pre-40S ribosomal subunit fromSaccharomyces cerevisiae. Elife, 6, 2017
6EIH	The crystal structure of 14-3-3 epsilon in complex with the phosphorylated NELFE peptide Descriptor: 14-3-3 protein epsilon, SER-ILE-SEP-ARG Authors: Akutsu, M, Wagner, S.A, Beli, P. Deposit date: 2017-09-19 Release date: 2018-02-14 Last modified: 2019-10-16 Method: X-RAY DIFFRACTION (2.7 Å) Cite: p38-MK2 signaling axis regulates RNA metabolism after UV-light-induced DNA damage. Nat Commun, 9, 2018
6ETJ	HUMAN PFKFB3 IN COMPLEX WITH KAN0438241 Descriptor: 4-[[3-(5-fluoranyl-2-oxidanyl-phenyl)phenyl]sulfonylamino]-2-oxidanyl-benzoic acid, 6-O-phosphono-beta-D-fructofuranose, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3, ... Authors: Gustafsson, N.M.S, Lundback, T, Farnegardh, K, Groth, P, Wiitta, E, Jonsson, M, Hallberg, K, Pennisi, R, Huguet Ninou, A, Martinsson, J, Norstrom, C, Schultz, J, Andersson, M, Markova, N, Marttila, P, Norin, M, Olin, T, Helleday, T. Deposit date: 2017-10-26 Release date: 2018-11-07 Last modified: 2020-07-29 Method: X-RAY DIFFRACTION (2.51 Å) Cite: Targeting PFKFB3 radiosensitizes cancer cells and suppresses homologous recombination. Nat Commun, 9, 2018
7SSA	Cryo-EM structure of pioneer factor Cbf1 bound to the nucleosome Descriptor: Centromere-binding protein 1, DNA (137-MER), Histone H2A.1, ... Authors: Eek, P, Tan, S. Deposit date: 2021-11-10 Release date: 2023-04-05 Last modified: 2024-06-05 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Basic helix-loop-helix pioneer factors interact with the histone octamer to invade nucleosomes and generate nucleosome-depleted regions. Mol.Cell, 83, 2023
7TYR	Cryo-EM structure of the basal state of the Artemis:DNA-PKcs complex (see COMPND 13/14) Descriptor: DNA-dependent protein kinase catalytic subunit, Protein artemis Authors: Watanabe, G, Lieber, M.R, Williams, D.R. Deposit date: 2022-02-14 Release date: 2022-07-20 Last modified: 2022-08-03 Method: ELECTRON MICROSCOPY (3.33 Å) Cite: Structural analysis of the basal state of the Artemis:DNA-PKcs complex. Nucleic Acids Res., 50, 2022
7TMO	V1 complex lacking subunit C from Saccharomyces cerevisiae, State 1 Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, H(+)-transporting two-sector ATPase, ... Authors: Vasanthakumar, T, Keon, K.A, Bueler, S.A, Jaskolka, M.C, Rubinstein, J.L. Deposit date: 2022-01-19 Release date: 2022-04-06 Last modified: 2024-02-21 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Coordinated conformational changes in the V 1 complex during V-ATPase reversible dissociation. Nat.Struct.Mol.Biol., 29, 2022
7TMP	V1 complex lacking subunit C from Saccharomyces cerevisiae, State 2 Descriptor: ADENOSINE-5'-DIPHOSPHATE, H(+)-transporting two-sector ATPase, MAGNESIUM ION, ... Authors: Vasanthakumar, T, Keon, K.A, Bueler, S.A, Jaskolka, M.C, Rubinstein, J.L. Deposit date: 2022-01-19 Release date: 2022-04-06 Last modified: 2024-02-21 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Coordinated conformational changes in the V 1 complex during V-ATPase reversible dissociation. Nat.Struct.Mol.Biol., 29, 2022
7TMQ	V1 complex lacking subunit C from Saccharomyces cerevisiae, State 3 Descriptor: ADENOSINE-5'-DIPHOSPHATE, H(+)-transporting two-sector ATPase, MAGNESIUM ION, ... Authors: Vasanthakumar, T, Keon, K.A, Bueler, S.A, Jaskolka, M.C, Rubinstein, J.L. Deposit date: 2022-01-19 Release date: 2022-04-06 Last modified: 2024-02-21 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Coordinated conformational changes in the V 1 complex during V-ATPase reversible dissociation. Nat.Struct.Mol.Biol., 29, 2022
7TMM	Complete V1 Complex from Saccharomyces cerevisiae Descriptor: ADENOSINE-5'-DIPHOSPHATE, H(+)-transporting two-sector ATPase, V-ATPase subunit E, ... Authors: Vasanthakumar, T, Keon, K.A, Bueler, S.A, Jaskolka, M.C, Rubinstein, J.L. Deposit date: 2022-01-19 Release date: 2022-04-06 Last modified: 2024-02-21 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: Coordinated conformational changes in the V 1 complex during V-ATPase reversible dissociation. Nat.Struct.Mol.Biol., 29, 2022
7TMR	V-ATPase from Saccharomyces cerevisiae, State 1 Descriptor: ADENOSINE-5'-DIPHOSPHATE, H(+)-transporting two-sector ATPase, V-type proton ATPase subunit C, ... Authors: Vasanthakumar, T, Keon, K.A, Bueler, S.A, Jaskolka, M.C, Rubinstein, J.L. Deposit date: 2022-01-19 Release date: 2022-04-13 Last modified: 2024-02-21 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: Coordinated conformational changes in the V 1 complex during V-ATPase reversible dissociation. Nat.Struct.Mol.Biol., 29, 2022
6GGZ	NMR structure of the scorpion toxin AmmTx3 Descriptor: Potassium channel toxin alpha-KTx 15.3 Authors: Landon, C, Meudal, H. Deposit date: 2018-05-04 Release date: 2019-01-30 Last modified: 2020-03-11 Method: SOLUTION NMR Cite: Synthesis by native chemical ligation and characterization of the scorpion toxin AmmTx3. Bioorg. Med. Chem., 27, 2019
6GV6	Cadmium(II) form of shortened metallothionein from Pseudomonas fluorescens Q2-87 (residues: 1-52) Descriptor: CADMIUM ION, metallothionein Authors: Habjanic, J, Zerbe, O, Freisinger, E. Deposit date: 2018-06-20 Release date: 2018-09-19 Last modified: 2023-06-14 Method: SOLUTION NMR Cite: A histidine-rich Pseudomonas metallothionein with a disordered tail displays higher binding capacity for cadmium than zinc. Metallomics, 10, 2018
6GV7	Cadmium(II) form of A44H mutant of shortened metallothionein from Pseudomonas fluorescens Q2-87 (residues 1-52) Descriptor: CADMIUM ION, metallothionein Authors: Habjanic, J, Zerbe, O, Freisinger, E. Deposit date: 2018-06-20 Release date: 2018-09-19 Last modified: 2023-06-14 Method: SOLUTION NMR Cite: A histidine-rich Pseudomonas metallothionein with a disordered tail displays higher binding capacity for cadmium than zinc. Metallomics, 10, 2018
5XSG	Ultrahigh resolution structure of FUS (37-42) SYSGYS determined by MicroED Descriptor: RNA-binding protein FUS Authors: Luo, F, Gui, X, Zhou, H, Li, D, Li, X, Liu, C. Deposit date: 2017-06-14 Release date: 2018-04-04 Last modified: 2024-03-27 Method: ELECTRON CRYSTALLOGRAPHY (0.73 Å) Cite: Atomic structures of FUS LC domain segments reveal bases for reversible amyloid fibril formation. Nat. Struct. Mol. Biol., 25, 2018
1OA6	The solution structure of bovine pancreatic trypsin inhibitor at high pressure Descriptor: PANCREATIC TRYPSIN INHIBITOR Authors: Williamson, M.P, Akasaka, K, Refaee, M. Deposit date: 2003-01-02 Release date: 2003-08-28 Last modified: 2011-07-13 Method: SOLUTION NMR Cite: The Solution Structure of Bovine Pancreatic Trypsin Inhibitor at High Pressure Protein Sci., 12, 2003
1P5A	Conformational Mapping of the N-terminal Peptide of HIV-1 GP41 in lipid detergent and aqueous environments using 13C-enhanced Fourier Transform Infrared Spectroscopy Descriptor: Envelope polyprotein GP160 Authors: Gordon, L.M, Mobley, P.W, Lee, W, Eskandari, S, Kaznessis, Y.N, Sherman, M.A, Waring, A.J. Deposit date: 2003-04-25 Release date: 2003-05-20 Last modified: 2011-07-13 Method: INFRARED SPECTROSCOPY Cite: Conformational mapping of the N-terminal peptide of HIV-1 gp41 in lipid detergent and aqueous environments using 13C-enhanced Fourier transform infrared spectroscopy. Protein Sci., 13, 2004
1PBZ	DE NOVO DESIGNED PEPTIDE-METALLOPORPHYRIN COMPLEX, SOLUTION STRUCTURE Descriptor: COPROPORPHYRIN I CONTAINING CO(III), De novo designed cyclic peptide Authors: Wang, J, Rosenblatt, M.M, Suslick, K.S. Deposit date: 2003-05-15 Release date: 2003-12-09 Last modified: 2022-02-23 Method: SOLUTION NMR Cite: De novo designed cyclic-peptide heme complexes Proc.Natl.Acad.Sci.USA, 100, 2003
5YVG	Crystal structure of Karyopherin beta2 in complex with FUS(full length) Descriptor: RNA-binding protein FUS, Transportin-1 Authors: Yoshizawa, T, Fung, H.Y.J, Chook, Y.M. Deposit date: 2017-11-25 Release date: 2018-05-16 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (4.05 Å) Cite: Nuclear Import Receptor Inhibits Phase Separation of FUS through Binding to Multiple Sites. Cell, 173, 2018
5YZ0	Cryo-EM Structure of human ATR-ATRIP complex Descriptor: ATR-interacting protein, Serine/threonine-protein kinase ATR Authors: Rao, Q, Liu, M, Tian, Y, Wu, Z, Wang, H, Wang, J, Xu, Y. Deposit date: 2017-12-11 Release date: 2018-01-31 Last modified: 2019-11-06 Method: ELECTRON MICROSCOPY (4.7 Å) Cite: Cryo-EM structure of human ATR-ATRIP complex. Cell Res., 28, 2018
3SHV	Crystal structure of human MCPH1 tandem BRCT domains-gamma H2AX complex Descriptor: Histone H2A.x, Microcephalin Authors: Shao, Z.H, Li, F.D, Yan, W. Deposit date: 2011-06-17 Release date: 2011-12-28 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Specific recognition of phosphorylated tail of H2AX by the tandem BRCT domains of MCPH1 revealed by complex structure J.Struct.Biol., 177, 2012

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