1A8J

IMMUNOGLOBULIN LAMBDA LIGHT CHAIN DIMER (MCG) COMPLEX WITH ASPARTAME

Summary for 1A8J

• Entry DOI: 10.2210/pdb1a8j/pdb
• Descriptor: IMMUNOGLOBULIN LAMBDA LIGHT CHAIN DIMER (MCG), N-L-ALPHA-ASPARTYL L-PHENYLALANINE 1-METHYL ESTER (2 entities in total)
• Functional Keywords: aspartame, ligand binding, immunotherapeutic agent, surrogate receptor, mcg(human) bence-jones dimer, immunoglobulin
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 46254.73

Authors

Edmundson, A.B.,Manion, C.V. (deposition date: 1998-03-26, release date: 1998-06-17, Last modification date: 2024-10-09)

Primary citation

Edmundson, A.B.,Manion, C.V.
Treatment of osteoarthritis with aspartame.
Clin.Pharmacol.Ther., 63:580-593, 1998

PubMed Abstract: The binding of sweet-tasting compounds in a human (Mcg) Bence-Jones dimer has been characterized by x-ray crystallography. Aspartame binding in this immunoglobulin fragment is remarkable. Unexpected pain relief noted by A.B.E., a crystallographer with diagnosed osteoarthritis, suggested that the accommodation of aspartame in the active site of the dimer may represent surrogate binding by other proteins, with analgesia as the outcome.

PubMed: 9630831

Experimental method

X-RAY DIFFRACTION (2.7 Å)