6O1F

Complex between soybean trypsin inhibitor beta1-tryptase and a humanized fab

Summary for 6O1F

• Entry DOI: 10.2210/pdb6o1f/pdb
• Related: 4a6l
• Descriptor: Tryptase alpha/beta-1, Heavy Chain hu31A.v11, Trypsin inhibitor A, ... (6 entities in total)
• Functional Keywords: antibody, fab, tryptase, inhibitor, immune system, immune system-hydrolase complex, immune system/hydrolase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 98476.37

Authors

Ultsch, M.H.,Yi, T. (deposition date: 2019-02-19, release date: 2019-10-16, Last modification date: 2023-10-11)

• Primary citation: Maun, H.R.,Jackman, J.K.,Choy, D.F.,Loyet, K.M.,Staton, T.L.,Jia, G.,Dressen, A.,Hackney, J.A.,Bremer, M.,Walters, B.T.,Vij, R.,Chen, X.,Trivedi, N.N.,Morando, A.,Lipari, M.T.,Franke, Y.,Wu, X.,Zhang, J.,Liu, J.,Wu, P.,Chang, D.,Orozco, L.D.,Christensen, E.,Wong, M.,Corpuz, R.,Hang, J.Q.,Lutman, J.,Sukumaran, S.,Wu, Y.,Ubhayakar, S.,Liang, X.,Schwartz, L.B.,Babina, M.,Woodruff, P.G.,Fahy, J.V.,Ahuja, R.,Caughey, G.H.,Kusi, A.,Dennis, M.S.,Eigenbrot, C.,Kirchhofer, D.,Austin, C.D.,Wu, L.C.,Koerber, J.T.,Lee, W.P.,Yaspan, B.L.,Alatsis, K.R.,Arron, J.R.,Lazarus, R.A.,Yi, T.; An Allosteric Anti-tryptase Antibody for the Treatment of Mast Cell-Mediated Severe Asthma.; Cell, 179:417-431.e19, 2019; PubMed: 31585081; DOI: 10.1016/j.cell.2019.09.009

Experimental method

X-RAY DIFFRACTION (2.15 Å)