7PUE

Human serum and glucocorticoid-regulated kinase 1 in complex with pyrazolopyridine inhibitor 3a

Summary for 7PUE

Entry DOI	10.2210/pdb7pue/pdb
Descriptor	Serine/threonine-protein kinase Sgk1, GLYCEROL, 6-[4-[[2,3-bis(chloranyl)phenyl]sulfonylamino]phenyl]-~{N}-[(3~{R})-pyrrolidin-3-yl]-2~{H}-pyrazolo[3,4-b]pyridine-4-carboxamide, ... (4 entities in total)
Functional Keywords	serine/threonine protein kinase, atp-competitive inhibitor, dfg-loop, hinge-binder, osteoarthritis, cartilage degradation, pyrazolo-pyridine, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	43227.09
Authors	Dreyer, M.K.,Halland, N.,Nazare, M. (deposition date: 2021-09-29, release date: 2021-12-01, Last modification date: 2022-02-09)
Primary citation	Halland, N.,Schmidt, F.,Weiss, T.,Li, Z.,Czech, J.,Saas, J.,Ding-Pfennigdorff, D.,Dreyer, M.K.,Strubing, C.,Nazare, M. Rational Design of Highly Potent, Selective, and Bioavailable SGK1 Protein Kinase Inhibitors for the Treatment of Osteoarthritis. J.Med.Chem., 65:1567-1584, 2022 Cited by PubMed: 34931844 DOI: 10.1021/acs.jmedchem.1c01601 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.506 Å)

Structure validation