7PUE
Human serum and glucocorticoid-regulated kinase 1 in complex with pyrazolopyridine inhibitor 3a
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Serine/threonine-protein kinase Sgk1 | polymer | 375 | 42511.5 | 1 | UniProt (O00141) Pfam (PF00069) Pfam (PF00433) | Homo sapiens (Human) | Serum/glucocorticoid-regulated kinase 1 |
| 2 | B, C (A) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 3 | D (A) | 6-[4-[[2,3-bis(chloranyl)phenyl]sulfonylamino]phenyl]-~{N}-[(3~{R})-pyrrolidin-3-yl]-2~{H}-pyrazolo[3,4-b]pyridine-4-carboxamide | non-polymer | 531.4 | 1 | Chemie (86H) | |||
| 4 | E (A) | water | water | 18.0 | 24 | Chemie (HOH) |
Sequence modifications
A: 60 - 431 (UniProt: O00141)
| PDB | External Database | Details |
|---|---|---|
| Gly 57 | - | expression tag |
| Ala 58 | - | expression tag |
| Met 59 | - | expression tag |
| Ala 192 | Arg 192 | engineered mutation |
| Asp 422 | Ser 422 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 42511.5 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 715.6 | |
| All* | Total formula weight | 43227.1 |
