7ZQX

Human galectin-3c in complex with a galactose derivative

Summary for 7ZQX

Entry DOI	10.2210/pdb7zqx/pdb
Descriptor	Galectin-3, GLYCEROL, THIOCYANATE ION, ... (7 entities in total)
Functional Keywords	inhibitor, complex, sugar binding protein
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	16496.91
Authors	Zetterberg, F.,Nilsson, U.J.,Hakansson, M.,Logan, D.T. (deposition date: 2022-05-03, release date: 2022-11-02, Last modification date: 2024-01-31)
Primary citation	Zetterberg, F.R.,MacKinnon, A.,Brimert, T.,Gravelle, L.,Johnsson, R.E.,Kahl-Knutson, B.,Leffler, H.,Nilsson, U.J.,Pedersen, A.,Peterson, K.,Roper, J.A.,Schambye, H.,Slack, R.J.,Tantawi, S. Discovery and Optimization of the First Highly Effective and Orally Available Galectin-3 Inhibitors for Treatment of Fibrotic Disease. J.Med.Chem., 65:12626-12638, 2022 Cited by PubMed: 36154172 DOI: 10.1021/acs.jmedchem.2c00660 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.05 Å)

Structure validation