8U37

Crystal structure of the catalytic domain of human PKC alpha (D463N, V568I, S657E) in complex with NVP-CJL037 at 2.48-A resolution

Summary for 8U37

• Entry DOI: 10.2210/pdb8u37/pdb
• Related: 8uak
• Descriptor: Protein kinase C alpha type, (6M)-3-amino-N-{4-[(3R,4S)-4-amino-3-methoxypiperidin-1-yl]pyridin-3-yl}-6-[3-(trifluoromethoxy)pyridin-2-yl]pyrazine-2-carboxamide, MAGNESIUM ION, ... (4 entities in total)
• Functional Keywords: transferase-inhibitor complex, transferase/inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 41210.18

Authors

Romanowski, M.J.,Lam, J.,Visser, M. (deposition date: 2023-09-07, release date: 2024-01-24, Last modification date: 2024-01-31)

• Primary citation: Visser, M.,Papillon, J.P.N.,Luzzio, M.,LaMarche, M.J.,Fan, J.,Michael, W.,Wang, D.,Zhang, A.,Straub, C.,Mathieu, S.,Kato, M.,Palermo, M.,Chen, C.,Ramsey, T.,Joud, C.,Barrett, R.,Vattay, A.,Guo, R.,Bric, A.,Chung, F.,Liang, G.,Romanowski, M.J.,Lam, J.,Thohan, S.,Atassi, F.,Wylie, A.,Cooke, V.G.; Discovery of Darovasertib (NVP-LXS196), a Pan-PKC Inhibitor for the Treatment of Metastatic Uveal Melanoma.; J.Med.Chem., 67:1447-1459, 2024; PubMed: 38198520; DOI: 10.1021/acs.jmedchem.3c02002

Experimental method

X-RAY DIFFRACTION (2.48 Å)