1X70

HUMAN DIPEPTIDYL PEPTIDASE IV IN COMPLEX WITH A BETA AMINO ACID INHIBITOR

Summary for 1X70

• Entry DOI: 10.2210/pdb1x70/pdb
• Descriptor: Dipeptidyl peptidase IV, 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• Functional Keywords: alpha/beta, beta-propeller, dimer, hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 174937.77

Authors

Kim, D.,Wang, L.,Beconi, M.,Eiermann, G.J.,Fisher, M.H.,He, H.,Hickey, G.J.,Leiting, B.,Lyons, K. (deposition date: 2004-08-12, release date: 2005-01-18, Last modification date: 2023-08-23)

• Primary citation: Kim, D.,Wang, L.,Beconi, M.,Eiermann, G.J.,Fisher, M.H.,He, H.,Hickey, G.J.,Kowalchick, J.E.,Leiting, B.,Lyons, K.,Marsilio, F.,McCann, M.E.,Patel, R.A.,Petrov, A.,Scapin, G.,Patel, S.B.,Roy, R.S.,Wu, J.K.,Wyvratt, M.J.,Zhang, B.B.,Zhu, L.,Thornberry, N.A.,Weber, A.E.; (2R)-4-Oxo-4-[3-(Trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin- 7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine: A Potent, Orally Active Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes; J.Med.Chem., 48:141-151, 2005; PubMed: 15634008; DOI: 10.1021/jm0493156

Experimental method

X-RAY DIFFRACTION (2.1 Å)