7Y1R
 
 | | Human L-TGF-beta1 in complex with the anchor protein LRRC33 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Duan, Z, Zhang, Z. | | Deposit date: | 2022-06-08 | | Release date: | 2022-08-31 | | Last modified: | 2022-09-07 | | Method: | ELECTRON MICROSCOPY (4.01 Å) | | Cite: | Specificity of TGF-beta 1 signal designated by LRRC33 and integrin alpha V beta 8.
Nat Commun, 13, 2022
|
|
8C7H
 | | Cryo-EM Map of the latTGF-beta 28G11 Fab complex | | Descriptor: | 28G11 Fab heavy chain, 28G11 Fab light chain, Transforming growth factor beta activator LRRC32, ... | | Authors: | Ebenhoch, R, Nar, H. | | Deposit date: | 2023-01-16 | | Release date: | 2023-03-01 | | Last modified: | 2023-03-29 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | Anti-GARP Antibodies Inhibit Release of TGF-beta by Regulatory T Cells via Different Modes of Action, but Do Not Influence Their Function In Vitro.
Immunohorizons, 7, 2023
|
|
8DC0
 | |
3QB4
 | |
3RJR
 | | Crystal Structure of pro-TGF beta 1 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Transforming growth factor beta-1 | | Authors: | Zhu, J.H, Shi, M.L, Springer, T.A. | | Deposit date: | 2011-04-15 | | Release date: | 2011-06-15 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (3.05 Å) | | Cite: | Latent TGF-Beta structure and activation
Nature, 474, 2011
|
|
3SEK
 | | Crystal Structure of the Myostatin:Follistatin-like 3 Complex | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Follistatin-related protein 3, Growth/differentiation factor 8 | | Authors: | Cash, J.N, Thompson, T.B. | | Deposit date: | 2011-06-10 | | Release date: | 2011-11-02 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.401 Å) | | Cite: | Structure of myostatinfollistatin-like 3: N-terminal domains of follistatin-type molecules exhibit alternate modes of binding.
J.Biol.Chem., 287, 2012
|
|
5VQF
 | | Crystal Structure of pro-TGF-beta 1 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Transforming growth factor beta-1, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | | Authors: | Zhao, B, Xu, S, Dong, X, Lu, C, Springer, T.A. | | Deposit date: | 2017-05-08 | | Release date: | 2017-11-15 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Prodomain-growth factor swapping in the structure of pro-TGF-beta 1.
J. Biol. Chem., 293, 2018
|
|
5VZ4
 | | Receptor-growth factor crystal structure at 2.20 Angstrom resolution | | Descriptor: | 1,2-ETHANEDIOL, BROMIDE ION, GDNF family receptor alpha-like, ... | | Authors: | Lakshminarasimhan, D, White, A, Suto, R.K. | | Deposit date: | 2017-05-26 | | Release date: | 2017-09-27 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15.
Nature, 550, 2017
|
|
5VQP
 | | Crystal structure of human pro-TGF-beta1 | | Descriptor: | Transforming growth factor beta-1, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | | Authors: | Zhao, B, Xu, S, Dong, X, Lu, C, Springer, T.A. | | Deposit date: | 2017-05-09 | | Release date: | 2017-11-15 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Prodomain-growth factor swapping in the structure of pro-TGF-beta 1.
J. Biol. Chem., 293, 2018
|
|
2B0U
 | | The Structure of the Follistatin:Activin Complex | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, Follistatin, IRIDIUM (III) ION, ... | | Authors: | Thompson, T.B, Lerch, T.F, Cook, R.W, Woodruff, T.K, Jardetzky, T.S. | | Deposit date: | 2005-09-14 | | Release date: | 2005-10-11 | | Last modified: | 2017-10-11 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | The Structure of the Follistatin:Activin Complex Reveals Antagonism of Both Type I and Type II Receptor Binding.
Dev.Cell, 9, 2005
|
|
2ARP
 | | Activin A in complex with Fs12 fragment of follistatin | | Descriptor: | 2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL, Follistatin, GLYCEROL, ... | | Authors: | Harrington, A.E, Morris-Triggs, S.A, Ruotolo, B.T, Robinson, C.V, Ohnuma, S, Hyvonen, M. | | Deposit date: | 2005-08-21 | | Release date: | 2006-03-07 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structural basis for the inhibition of activin signalling by follistatin
Embo J., 25, 2006
|
|
4UI1
 | | Crystal structure of the human RGMC-BMP2 complex | | Descriptor: | 1,2-ETHANEDIOL, BONE MORPHOGENETIC PROTEIN 2, CHLORIDE ION, ... | | Authors: | Healey, E.G, Bishop, B, Elegheert, J, Bell, C.H, Padilla-Parra, S, Siebold, C. | | Deposit date: | 2015-03-27 | | Release date: | 2015-05-06 | | Last modified: | 2015-06-17 | | Method: | X-RAY DIFFRACTION (2.35 Å) | | Cite: | Repulsive Guidance Molecule is a Structural Bridge between Neogenin and Bone Morphogenetic Protein.
Nat.Struct.Mol.Biol., 22, 2015
|
|
4UHY
 | | Crystal structure of the human RGMA-BMP2 complex | | Descriptor: | BONE MORPHOGENETIC PROTEIN 2, REPULSIVE GUIDANCE MOLECULE A | | Authors: | Healey, E.G, Bishop, B, Elegheert, J, Bell, C.H, Padilla-Parra, S, Siebold, C. | | Deposit date: | 2015-03-27 | | Release date: | 2015-05-06 | | Last modified: | 2015-06-17 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Repulsive Guidance Molecule is a Structural Bridge between Neogenin and Bone Morphogenetic Protein.
Nat.Struct.Mol.Biol., 22, 2015
|
|
4UHZ
 | | Crystal structure of the human RGMB-BMP2 complex, crystal form 1 | | Descriptor: | BONE MORPHOGENETIC PROTEIN 2, RGM DOMAIN FAMILY MEMBER B, SULFATE ION | | Authors: | Healey, E.G, Bishop, B, Elegheert, J, Bell, C.H, Padilla-Parra, S, Siebold, C. | | Deposit date: | 2015-03-27 | | Release date: | 2015-05-06 | | Last modified: | 2015-06-17 | | Method: | X-RAY DIFFRACTION (2.85 Å) | | Cite: | Repulsive Guidance Molecule is a Structural Bridge between Neogenin and Bone Morphogenetic Protein.
Nat.Struct.Mol.Biol., 22, 2015
|
|
4UI2
 | | Crystal structure of the ternary RGMB-BMP2-NEO1 complex | | Descriptor: | ACETATE ION, BONE MORPHOGENETIC PROTEIN 2, BMP2, ... | | Authors: | Healey, E.G, Bishop, B, Elegheert, J, Bell, C.H, Padilla-Parra, S, Siebold, C. | | Deposit date: | 2015-03-27 | | Release date: | 2015-05-06 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (3.15 Å) | | Cite: | Repulsive Guidance Molecule is a Structural Bridge between Neogenin and Bone Morphogenetic Protein.
Nat.Struct.Mol.Biol., 22, 2015
|
|
4UI0
 | | Crystal structure of the human RGMB-BMP2 complex, crystal form 2 | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, BONE MORPHOGENETIC PROTEIN 2, CHLORIDE ION, ... | | Authors: | Healey, E.G, Bishop, B, Elegheert, J, Bell, C.H, Padilla-Parra, S, Siebold, C. | | Deposit date: | 2015-03-27 | | Release date: | 2015-05-06 | | Last modified: | 2015-06-17 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Repulsive Guidance Molecule is a Structural Bridge between Neogenin and Bone Morphogenetic Protein.
Nat.Struct.Mol.Biol., 22, 2015
|
|
6SF2
 | | Ternary complex of human bone morphogenetic protein 9 (BMP9) growth factor domain, its prodomain and extracellular domain of activin receptor-like kinase 1 (ALK1). | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Growth/differentiation factor 2, Serine/threonine-protein kinase receptor R3 | | Authors: | Salmon, R.M, Guo, J, Yu, M, Li, W. | | Deposit date: | 2019-07-31 | | Release date: | 2020-04-08 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (3.3 Å) | | Cite: | Molecular basis of ALK1-mediated signalling by BMP9/BMP10 and their prodomain-bound forms.
Nat Commun, 11, 2020
|
|
3EO1
 | |
3EVS
 | | Crystal structure of the GDF-5:BMP receptor IB complex. | | Descriptor: | Bone morphogenetic protein receptor type-1B, Growth/differentiation factor 5 | | Authors: | Kotzsch, A, Mueller, T.D. | | Deposit date: | 2008-10-13 | | Release date: | 2009-03-10 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Crystal structure analysis reveals a spring-loaded latch as molecular mechanism for GDF-5-type I receptor specificity.
Embo J., 28, 2009
|
|
6UJA
 | | Integrin alpha-v beta-8 in complex with pro-TGF-beta1 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | Authors: | Campbell, M.G, Cormier, A, Cheng, Y, Nishimura, S.L. | | Deposit date: | 2019-10-02 | | Release date: | 2020-02-05 | | Last modified: | 2020-07-29 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Cryo-EM Reveals Integrin-Mediated TGF-beta Activation without Release from Latent TGF-beta.
Cell, 180, 2020
|
|
6UMX
 | | Structural basis for specific inhibition of extracellular activation of pro/latent myostatin by SRK-015 | | Descriptor: | GL29H4-16 Fab Heavy Chain,GL29H4-16 Fab Heavy Chain, GL29H4-16 Fab Light Chain,GL29H4-16 Fab Light Chain, GLYCEROL, ... | | Authors: | Dagbay, K.B, Treece, E, Streich Jr, F.C, Jackson, J.W, Faucette, R.R, Nikiforov, A, Lin, S.C, Bostion, C.J, Nicholls, S.B, Capili, A.D, Carven, G.J. | | Deposit date: | 2019-10-10 | | Release date: | 2020-02-26 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.79 Å) | | Cite: | Structural basis of specific inhibition of extracellular activation of pro- or latent myostatin by the monoclonal antibody SRK-015.
J.Biol.Chem., 295, 2020
|
|
5TX4
 | | Derivative of mouse TGF-beta2, with a deletion of residues 52-71 and K25R, R26K, L51R, A74K, C77S, L89V, I92V, K94R T95K, I98V single amino acid substitutions, bound to human TGF-beta type II receptor ectodomain residues 15-130 | | Descriptor: | TGF-beta receptor type-2, Transforming growth factor beta-2 | | Authors: | Hinck, A.P, Kim, S. | | Deposit date: | 2016-11-15 | | Release date: | 2017-03-01 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (1.876 Å) | | Cite: | An engineered transforming growth factor beta (TGF-beta ) monomer that functions as a dominant negative to block TGF-beta signaling.
J. Biol. Chem., 292, 2017
|
|
5TY4
 | | MicroED structure of a complex between monomeric TGF-b and its receptor, TbRII, at 2.9 A resolution | | Descriptor: | TGF-beta receptor type-2, mmTGF-b2-7m | | Authors: | Weiss, S.C, de la Cruz, M.J, Hattne, J, Shi, D, Reyes, F.E, Callero, G, Gonen, T. | | Deposit date: | 2016-11-18 | | Release date: | 2017-04-26 | | Last modified: | 2023-10-04 | | Method: | ELECTRON CRYSTALLOGRAPHY (2.9 Å) | | Cite: | Atomic-resolution structures from fragmented protein crystals with the cryoEM method MicroED.
Nat. Methods, 14, 2017
|
|
3FUB
 | | Crystal structure of GDNF-GFRalpha1 complex | | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Parkash, V, Goldman, A. | | Deposit date: | 2009-01-14 | | Release date: | 2009-06-02 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.35 Å) | | Cite: | Comparison of GFL-GFRalpha complexes: further evidence relating GFL bend angle to RET signalling
Acta Crystallogr.,Sect.F, 65, 2009
|
|
2GH0
 | | Growth factor/receptor complex | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GDNF family receptor alpha-3, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Wang, X.Q. | | Deposit date: | 2006-03-24 | | Release date: | 2006-06-27 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (1.92 Å) | | Cite: | Structure of Artemin Complexed with Its Receptor GFRalpha3: Convergent Recognition of Glial Cell Line-Derived Neurotrophic Factors.
Structure, 14, 2006
|
|
