5VZ4

Receptor-growth factor crystal structure at 2.20 Angstrom resolution

Summary for 5VZ4

• Entry DOI: 10.2210/pdb5vz4/pdb
• Related: 5VZ3
• Descriptor: Growth/differentiation factor 15, GDNF family receptor alpha-like, BROMIDE ION, ... (6 entities in total)
• Functional Keywords: receptor, growth factor, signaling protein-protein binding complex, signaling protein/protein binding
• Biological source: Homo sapiens (Human); More
• Cellular location: Secreted : Q99988; Membrane ; Single-pass membrane protein : Q6UXV0
• Total number of polymer chains: 2
• Total formula weight: 40507.08

Authors

Lakshminarasimhan, D.,White, A.,Suto, R.K. (deposition date: 2017-05-26, release date: 2017-09-27, Last modification date: 2023-10-04)

• Primary citation: Hsu, J.Y.,Crawley, S.,Chen, M.,Ayupova, D.A.,Lindhout, D.A.,Higbee, J.,Kutach, A.,Joo, W.,Gao, Z.,Fu, D.,To, C.,Mondal, K.,Li, B.,Kekatpure, A.,Wang, M.,Laird, T.,Horner, G.,Chan, J.,McEntee, M.,Lopez, M.,Lakshminarasimhan, D.,White, A.,Wang, S.P.,Yao, J.,Yie, J.,Matern, H.,Solloway, M.,Haldankar, R.,Parsons, T.,Tang, J.,Shen, W.D.,Alice Chen, Y.,Tian, H.,Allan, B.B.; Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15.; Nature, 550:255-259, 2017; PubMed: 28953886; DOI: 10.1038/nature24042

Experimental method

X-RAY DIFFRACTION (2.2 Å)