5VZ4
Receptor-growth factor crystal structure at 2.20 Angstrom resolution
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Growth/differentiation factor 15 | polymer | 112 | 12303.2 | 1 | UniProt (Q99988) Pfam (PF00019) | Homo sapiens (Human) | GDF-15, Macrophage inhibitory cytokine 1, MIC-1, NSAID-activated gene 1 protein, NAG-1, NSAID-regulated gene 1 protein, NRG-1, Placental TGF-beta, Placental bone morphogenetic protein, Prostate differentiation factor |
| 2 | B (B) | GDNF family receptor alpha-like | polymer | 245 | 27665.7 | 1 | UniProt (Q6UXV0) Pfam (PF02351) | Homo sapiens (Human) | |
| 3 | C, D (A) | BROMIDE ION | non-polymer | 79.9 | 2 | Chemie (BR) | |||
| 4 | E, F, I (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 3 | Chemie (EDO) | |||
| 5 | G, H (B) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 6 | J, K (A, B) | water | water | 18.0 | 144 | Chemie (HOH) |
Sequence modifications
B: 115 - 351 (UniProt: Q6UXV0)
| PDB | External Database | Details |
|---|---|---|
| His 107 | - | expression tag |
| His 108 | - | expression tag |
| His 109 | - | expression tag |
| His 110 | - | expression tag |
| His 111 | - | expression tag |
| His 112 | - | expression tag |
| Gly 113 | - | expression tag |
| Gly 114 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 39968.9 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 538.1 | |
| All* | Total formula weight | 40507.1 |
