5VZ4

Receptor-growth factor crystal structure at 2.20 Angstrom resolution

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Growth/differentiation factor 15	polymer	112	12303.2	1	UniProt (Q99988) Pfam (PF00019) In PDB	Homo sapiens (Human)	GDF-15, Macrophage inhibitory cytokine 1, MIC-1, NSAID-activated gene 1 protein, NAG-1, NSAID-regulated gene 1 protein, NRG-1, Placental TGF-beta, Placental bone morphogenetic protein, Prostate differentiation factor
2	B	GDNF family receptor alpha-like	polymer	245	27665.7	1	UniProt (Q6UXV0) Pfam (PF02351) In PDB	Homo sapiens (Human)
3	A	BROMIDE ION	non-polymer		79.9	2	Chemie (BR)
4	A, B	1,2-ETHANEDIOL	non-polymer		62.1	3	Chemie (EDO)
5	B	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
6		water	water		18.0	144	Chemie (HOH)

Sequence modifications

B: 115 - 351 (UniProt: Q6UXV0)

PDB	External Database	Details
His 107	-	expression tag
His 108	-	expression tag
His 109	-	expression tag
His 110	-	expression tag
His 111	-	expression tag
His 112	-	expression tag
Gly 113	-	expression tag
Gly 114	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	39968.9
Non-Polymers*	Number of molecules	7
	Total formula weight	538.1
All*	Total formula weight	40507.1

*Water molecules are not included.