5VQF

Crystal Structure of pro-TGF-beta 1

Summary for 5VQF

DescriptorTransforming growth factor beta-1, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE (3 entities in total)
Functional Keywordspro-complex, latency, homodimer, protein binding
Biological sourceSus scrofa (Pig)
Cellular locationSecreted, extracellular space, extracellular matrix  P07200
Total number of polymer chains4
Total molecular weight167237.04
Authors
Zhao, B.,Xu, S.,Dong, X.,Lu, C.,Springer, T.A. (deposition date: 2017-05-08, release date: 2017-11-15, Last modification date: 2018-02-14)
Primary citation
Zhao, B.,Xu, S.,Dong, X.,Lu, C.,Springer, T.A.
Prodomain-growth factor swapping in the structure of pro-TGF-beta 1.
J. Biol. Chem., 293:1579-1589, 2018
PubMed: 29109152 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M117.809657
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.9 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.280700.3%18.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 5vqf
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More Biological unit images

Molmil generated image of 5vqf
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Molmil generated image of 5vqf
rotated about x axis by 90°
Molmil generated image of 5vqf
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (5vqf.pdb2.gz [243.43 KB])
Coordinate files for Biological unit (5vqf.pdb1.gz [235.91 KB])