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5VQF

Crystal Structure of pro-TGF-beta 1

Functional Information from GO Data
ChainGOidnamespacecontents
A0001837biological_processepithelial to mesenchymal transition
A0001933biological_processnegative regulation of protein phosphorylation
A0002062biological_processchondrocyte differentiation
A0002244biological_processhematopoietic progenitor cell differentiation
A0005114molecular_functiontype II transforming growth factor beta receptor binding
A0005125molecular_functioncytokine activity
A0005160molecular_functiontransforming growth factor beta receptor binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005902cellular_componentmicrovillus
A0006754biological_processATP biosynthetic process
A0006796biological_processphosphate-containing compound metabolic process
A0006954biological_processinflammatory response
A0007179biological_processtransforming growth factor beta receptor signaling pathway
A0007435biological_processsalivary gland morphogenesis
A0008083molecular_functiongrowth factor activity
A0008284biological_processpositive regulation of cell population proliferation
A0008285biological_processnegative regulation of cell population proliferation
A0009611biological_processresponse to wounding
A0009986cellular_componentcell surface
A0010628biological_processpositive regulation of gene expression
A0010629biological_processnegative regulation of gene expression
A0010718biological_processpositive regulation of epithelial to mesenchymal transition
A0010763biological_processpositive regulation of fibroblast migration
A0010936biological_processnegative regulation of macrophage cytokine production
A0014008biological_processpositive regulation of microglia differentiation
A0016202biological_processregulation of striated muscle tissue development
A0022408biological_processnegative regulation of cell-cell adhesion
A0030214biological_processhyaluronan catabolic process
A0030308biological_processnegative regulation of cell growth
A0030335biological_processpositive regulation of cell migration
A0031012cellular_componentextracellular matrix
A0031293biological_processmembrane protein intracellular domain proteolysis
A0031334biological_processpositive regulation of protein-containing complex assembly
A0032355biological_processresponse to estradiol
A0032570biological_processresponse to progesterone
A0032740biological_processpositive regulation of interleukin-17 production
A0032801biological_processreceptor catabolic process
A0032930biological_processpositive regulation of superoxide anion generation
A0032967biological_processpositive regulation of collagen biosynthetic process
A0034713molecular_functiontype I transforming growth factor beta receptor binding
A0034714molecular_functiontype III transforming growth factor beta receptor binding
A0035307biological_processpositive regulation of protein dephosphorylation
A0042127biological_processregulation of cell population proliferation
A0042306biological_processregulation of protein import into nucleus
A0042307biological_processpositive regulation of protein import into nucleus
A0042802molecular_functionidentical protein binding
A0043536biological_processpositive regulation of blood vessel endothelial cell migration
A0043537biological_processnegative regulation of blood vessel endothelial cell migration
A0045216biological_processcell-cell junction organization
A0045599biological_processnegative regulation of fat cell differentiation
A0045662biological_processnegative regulation of myoblast differentiation
A0045742biological_processpositive regulation of epidermal growth factor receptor signaling pathway
A0045786biological_processnegative regulation of cell cycle
A0045892biological_processnegative regulation of DNA-templated transcription
A0045893biological_processpositive regulation of DNA-templated transcription
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0048298biological_processpositive regulation of isotype switching to IgA isotypes
A0048535biological_processlymph node development
A0048642biological_processnegative regulation of skeletal muscle tissue development
A0050680biological_processnegative regulation of epithelial cell proliferation
A0050714biological_processpositive regulation of protein secretion
A0050921biological_processpositive regulation of chemotaxis
A0051247biological_processpositive regulation of protein metabolic process
A0051781biological_processpositive regulation of cell division
A0060391biological_processpositive regulation of SMAD protein signal transduction
A0070374biological_processpositive regulation of ERK1 and ERK2 cascade
A0070723biological_processresponse to cholesterol
A0071560biological_processcellular response to transforming growth factor beta stimulus
A0071895biological_processodontoblast differentiation
A0072562cellular_componentblood microparticle
A0085029biological_processextracellular matrix assembly
A0097191biological_processextrinsic apoptotic signaling pathway
A1900126biological_processnegative regulation of hyaluronan biosynthetic process
B0001837biological_processepithelial to mesenchymal transition
B0001933biological_processnegative regulation of protein phosphorylation
B0002062biological_processchondrocyte differentiation
B0002244biological_processhematopoietic progenitor cell differentiation
B0005114molecular_functiontype II transforming growth factor beta receptor binding
B0005125molecular_functioncytokine activity
B0005160molecular_functiontransforming growth factor beta receptor binding
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005902cellular_componentmicrovillus
B0006754biological_processATP biosynthetic process
B0006796biological_processphosphate-containing compound metabolic process
B0006954biological_processinflammatory response
B0007179biological_processtransforming growth factor beta receptor signaling pathway
B0007435biological_processsalivary gland morphogenesis
B0008083molecular_functiongrowth factor activity
B0008284biological_processpositive regulation of cell population proliferation
B0008285biological_processnegative regulation of cell population proliferation
B0009611biological_processresponse to wounding
B0009986cellular_componentcell surface
B0010628biological_processpositive regulation of gene expression
B0010629biological_processnegative regulation of gene expression
B0010718biological_processpositive regulation of epithelial to mesenchymal transition
B0010763biological_processpositive regulation of fibroblast migration
B0010936biological_processnegative regulation of macrophage cytokine production
B0014008biological_processpositive regulation of microglia differentiation
B0016202biological_processregulation of striated muscle tissue development
B0022408biological_processnegative regulation of cell-cell adhesion
B0030214biological_processhyaluronan catabolic process
B0030308biological_processnegative regulation of cell growth
B0030335biological_processpositive regulation of cell migration
B0031012cellular_componentextracellular matrix
B0031293biological_processmembrane protein intracellular domain proteolysis
B0031334biological_processpositive regulation of protein-containing complex assembly
B0032355biological_processresponse to estradiol
B0032570biological_processresponse to progesterone
B0032740biological_processpositive regulation of interleukin-17 production
B0032801biological_processreceptor catabolic process
B0032930biological_processpositive regulation of superoxide anion generation
B0032967biological_processpositive regulation of collagen biosynthetic process
B0034713molecular_functiontype I transforming growth factor beta receptor binding
B0034714molecular_functiontype III transforming growth factor beta receptor binding
B0035307biological_processpositive regulation of protein dephosphorylation
B0042127biological_processregulation of cell population proliferation
B0042306biological_processregulation of protein import into nucleus
B0042307biological_processpositive regulation of protein import into nucleus
B0042802molecular_functionidentical protein binding
B0043536biological_processpositive regulation of blood vessel endothelial cell migration
B0043537biological_processnegative regulation of blood vessel endothelial cell migration
B0045216biological_processcell-cell junction organization
B0045599biological_processnegative regulation of fat cell differentiation
B0045662biological_processnegative regulation of myoblast differentiation
B0045742biological_processpositive regulation of epidermal growth factor receptor signaling pathway
B0045786biological_processnegative regulation of cell cycle
B0045892biological_processnegative regulation of DNA-templated transcription
B0045893biological_processpositive regulation of DNA-templated transcription
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0048298biological_processpositive regulation of isotype switching to IgA isotypes
B0048535biological_processlymph node development
B0048642biological_processnegative regulation of skeletal muscle tissue development
B0050680biological_processnegative regulation of epithelial cell proliferation
B0050714biological_processpositive regulation of protein secretion
B0050921biological_processpositive regulation of chemotaxis
B0051247biological_processpositive regulation of protein metabolic process
B0051781biological_processpositive regulation of cell division
B0060391biological_processpositive regulation of SMAD protein signal transduction
B0070374biological_processpositive regulation of ERK1 and ERK2 cascade
B0070723biological_processresponse to cholesterol
B0071560biological_processcellular response to transforming growth factor beta stimulus
B0071895biological_processodontoblast differentiation
B0072562cellular_componentblood microparticle
B0085029biological_processextracellular matrix assembly
B0097191biological_processextrinsic apoptotic signaling pathway
B1900126biological_processnegative regulation of hyaluronan biosynthetic process
C0001837biological_processepithelial to mesenchymal transition
C0001933biological_processnegative regulation of protein phosphorylation
C0002062biological_processchondrocyte differentiation
C0002244biological_processhematopoietic progenitor cell differentiation
C0005114molecular_functiontype II transforming growth factor beta receptor binding
C0005125molecular_functioncytokine activity
C0005160molecular_functiontransforming growth factor beta receptor binding
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005902cellular_componentmicrovillus
C0006754biological_processATP biosynthetic process
C0006796biological_processphosphate-containing compound metabolic process
C0006954biological_processinflammatory response
C0007179biological_processtransforming growth factor beta receptor signaling pathway
C0007435biological_processsalivary gland morphogenesis
C0008083molecular_functiongrowth factor activity
C0008284biological_processpositive regulation of cell population proliferation
C0008285biological_processnegative regulation of cell population proliferation
C0009611biological_processresponse to wounding
C0009986cellular_componentcell surface
C0010628biological_processpositive regulation of gene expression
C0010629biological_processnegative regulation of gene expression
C0010718biological_processpositive regulation of epithelial to mesenchymal transition
C0010763biological_processpositive regulation of fibroblast migration
C0010936biological_processnegative regulation of macrophage cytokine production
C0014008biological_processpositive regulation of microglia differentiation
C0016202biological_processregulation of striated muscle tissue development
C0022408biological_processnegative regulation of cell-cell adhesion
C0030214biological_processhyaluronan catabolic process
C0030308biological_processnegative regulation of cell growth
C0030335biological_processpositive regulation of cell migration
C0031012cellular_componentextracellular matrix
C0031293biological_processmembrane protein intracellular domain proteolysis
C0031334biological_processpositive regulation of protein-containing complex assembly
C0032355biological_processresponse to estradiol
C0032570biological_processresponse to progesterone
C0032740biological_processpositive regulation of interleukin-17 production
C0032801biological_processreceptor catabolic process
C0032930biological_processpositive regulation of superoxide anion generation
C0032967biological_processpositive regulation of collagen biosynthetic process
C0034713molecular_functiontype I transforming growth factor beta receptor binding
C0034714molecular_functiontype III transforming growth factor beta receptor binding
C0035307biological_processpositive regulation of protein dephosphorylation
C0042127biological_processregulation of cell population proliferation
C0042306biological_processregulation of protein import into nucleus
C0042307biological_processpositive regulation of protein import into nucleus
C0042802molecular_functionidentical protein binding
C0043536biological_processpositive regulation of blood vessel endothelial cell migration
C0043537biological_processnegative regulation of blood vessel endothelial cell migration
C0045216biological_processcell-cell junction organization
C0045599biological_processnegative regulation of fat cell differentiation
C0045662biological_processnegative regulation of myoblast differentiation
C0045742biological_processpositive regulation of epidermal growth factor receptor signaling pathway
C0045786biological_processnegative regulation of cell cycle
C0045892biological_processnegative regulation of DNA-templated transcription
C0045893biological_processpositive regulation of DNA-templated transcription
C0045944biological_processpositive regulation of transcription by RNA polymerase II
C0048298biological_processpositive regulation of isotype switching to IgA isotypes
C0048535biological_processlymph node development
C0048642biological_processnegative regulation of skeletal muscle tissue development
C0050680biological_processnegative regulation of epithelial cell proliferation
C0050714biological_processpositive regulation of protein secretion
C0050921biological_processpositive regulation of chemotaxis
C0051247biological_processpositive regulation of protein metabolic process
C0051781biological_processpositive regulation of cell division
C0060391biological_processpositive regulation of SMAD protein signal transduction
C0070374biological_processpositive regulation of ERK1 and ERK2 cascade
C0070723biological_processresponse to cholesterol
C0071560biological_processcellular response to transforming growth factor beta stimulus
C0071895biological_processodontoblast differentiation
C0072562cellular_componentblood microparticle
C0085029biological_processextracellular matrix assembly
C0097191biological_processextrinsic apoptotic signaling pathway
C1900126biological_processnegative regulation of hyaluronan biosynthetic process
D0001837biological_processepithelial to mesenchymal transition
D0001933biological_processnegative regulation of protein phosphorylation
D0002062biological_processchondrocyte differentiation
D0002244biological_processhematopoietic progenitor cell differentiation
D0005114molecular_functiontype II transforming growth factor beta receptor binding
D0005125molecular_functioncytokine activity
D0005160molecular_functiontransforming growth factor beta receptor binding
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005902cellular_componentmicrovillus
D0006754biological_processATP biosynthetic process
D0006796biological_processphosphate-containing compound metabolic process
D0006954biological_processinflammatory response
D0007179biological_processtransforming growth factor beta receptor signaling pathway
D0007435biological_processsalivary gland morphogenesis
D0008083molecular_functiongrowth factor activity
D0008284biological_processpositive regulation of cell population proliferation
D0008285biological_processnegative regulation of cell population proliferation
D0009611biological_processresponse to wounding
D0009986cellular_componentcell surface
D0010628biological_processpositive regulation of gene expression
D0010629biological_processnegative regulation of gene expression
D0010718biological_processpositive regulation of epithelial to mesenchymal transition
D0010763biological_processpositive regulation of fibroblast migration
D0010936biological_processnegative regulation of macrophage cytokine production
D0014008biological_processpositive regulation of microglia differentiation
D0016202biological_processregulation of striated muscle tissue development
D0022408biological_processnegative regulation of cell-cell adhesion
D0030214biological_processhyaluronan catabolic process
D0030308biological_processnegative regulation of cell growth
D0030335biological_processpositive regulation of cell migration
D0031012cellular_componentextracellular matrix
D0031293biological_processmembrane protein intracellular domain proteolysis
D0031334biological_processpositive regulation of protein-containing complex assembly
D0032355biological_processresponse to estradiol
D0032570biological_processresponse to progesterone
D0032740biological_processpositive regulation of interleukin-17 production
D0032801biological_processreceptor catabolic process
D0032930biological_processpositive regulation of superoxide anion generation
D0032967biological_processpositive regulation of collagen biosynthetic process
D0034713molecular_functiontype I transforming growth factor beta receptor binding
D0034714molecular_functiontype III transforming growth factor beta receptor binding
D0035307biological_processpositive regulation of protein dephosphorylation
D0042127biological_processregulation of cell population proliferation
D0042306biological_processregulation of protein import into nucleus
D0042307biological_processpositive regulation of protein import into nucleus
D0042802molecular_functionidentical protein binding
D0043536biological_processpositive regulation of blood vessel endothelial cell migration
D0043537biological_processnegative regulation of blood vessel endothelial cell migration
D0045216biological_processcell-cell junction organization
D0045599biological_processnegative regulation of fat cell differentiation
D0045662biological_processnegative regulation of myoblast differentiation
D0045742biological_processpositive regulation of epidermal growth factor receptor signaling pathway
D0045786biological_processnegative regulation of cell cycle
D0045892biological_processnegative regulation of DNA-templated transcription
D0045893biological_processpositive regulation of DNA-templated transcription
D0045944biological_processpositive regulation of transcription by RNA polymerase II
D0048298biological_processpositive regulation of isotype switching to IgA isotypes
D0048535biological_processlymph node development
D0048642biological_processnegative regulation of skeletal muscle tissue development
D0050680biological_processnegative regulation of epithelial cell proliferation
D0050714biological_processpositive regulation of protein secretion
D0050921biological_processpositive regulation of chemotaxis
D0051247biological_processpositive regulation of protein metabolic process
D0051781biological_processpositive regulation of cell division
D0060391biological_processpositive regulation of SMAD protein signal transduction
D0070374biological_processpositive regulation of ERK1 and ERK2 cascade
D0070723biological_processresponse to cholesterol
D0071560biological_processcellular response to transforming growth factor beta stimulus
D0071895biological_processodontoblast differentiation
D0072562cellular_componentblood microparticle
D0085029biological_processextracellular matrix assembly
D0097191biological_processextrinsic apoptotic signaling pathway
D1900126biological_processnegative regulation of hyaluronan biosynthetic process
Functional Information from PROSITE/UniProt
site_idPS00250
Number of Residues16
DetailsTGF_BETA_1 TGF-beta family signature. IhePkgYhanfClGpC
ChainResidueDetails
AILE282-CYS297

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsSITE: Cleavage; by FURIN => ECO:0000250|UniProtKB:P01137
ChainResidueDetails
AARG249
BARG249
CARG249
DARG249

site_idSWS_FT_FI2
Number of Residues8
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:21677751, ECO:0007744|PDB:3RJR
ChainResidueDetails
AASN53
AASN107
BASN53
BASN107
CASN53
CASN107
DASN53
DASN107

site_idSWS_FT_FI3
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AGLN147
BGLN147
CGLN147
DGLN147

222415

PDB entries from 2024-07-10

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