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5VQF

Crystal Structure of pro-TGF-beta 1

Replaces:  3RJR
Functional Information from GO Data
ChainGOidnamespacecontents
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0000902biological_processcell morphogenesis
A0001570biological_processvasculogenesis
A0001657biological_processureteric bud development
A0001775biological_processcell activation
A0001837biological_processepithelial to mesenchymal transition
A0001843biological_processneural tube closure
A0002028biological_processregulation of sodium ion transport
A0002040biological_processsprouting angiogenesis
A0002062biological_processchondrocyte differentiation
A0002069biological_processcolumnar/cuboidal epithelial cell maturation
A0002244biological_processhematopoietic progenitor cell differentiation
A0002460biological_processadaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
A0002513biological_processtolerance induction to self antigen
A0002859biological_processnegative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
A0003179biological_processheart valve morphogenesis
A0003180biological_processaortic valve morphogenesis
A0005114molecular_functiontype II transforming growth factor beta receptor binding
A0005125molecular_functioncytokine activity
A0005160molecular_functiontransforming growth factor beta receptor binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005902cellular_componentmicrovillus
A0006611biological_processprotein export from nucleus
A0006754biological_processATP biosynthetic process
A0006796biological_processphosphate-containing compound metabolic process
A0006874biological_processintracellular calcium ion homeostasis
A0006954biological_processinflammatory response
A0007179biological_processtransforming growth factor beta receptor signaling pathway
A0007219biological_processNotch signaling pathway
A0007435biological_processsalivary gland morphogenesis
A0007492biological_processendoderm development
A0007507biological_processheart development
A0008083molecular_functiongrowth factor activity
A0008283biological_processcell population proliferation
A0008284biological_processpositive regulation of cell population proliferation
A0008285biological_processnegative regulation of cell population proliferation
A0008354biological_processgerm cell migration
A0009611biological_processresponse to wounding
A0009986cellular_componentcell surface
A0010467biological_processgene expression
A0010468biological_processregulation of gene expression
A0010628biological_processpositive regulation of gene expression
A0010629biological_processnegative regulation of gene expression
A0010718biological_processpositive regulation of epithelial to mesenchymal transition
A0010763biological_processpositive regulation of fibroblast migration
A0010936biological_processnegative regulation of macrophage cytokine production
A0014003biological_processoligodendrocyte development
A0014008biological_processpositive regulation of microglia differentiation
A0016202biological_processregulation of striated muscle tissue development
A0019899molecular_functionenzyme binding
A0021915biological_processneural tube development
A0030214biological_processhyaluronan catabolic process
A0030217biological_processT cell differentiation
A0030279biological_processnegative regulation of ossification
A0030308biological_processnegative regulation of cell growth
A0030316biological_processosteoclast differentiation
A0030335biological_processpositive regulation of cell migration
A0030879biological_processmammary gland development
A0031012cellular_componentextracellular matrix
A0031293biological_processmembrane protein intracellular domain proteolysis
A0031334biological_processpositive regulation of protein-containing complex assembly
A0032355biological_processresponse to estradiol
A0032570biological_processresponse to progesterone
A0032667biological_processregulation of interleukin-23 production
A0032700biological_processnegative regulation of interleukin-17 production
A0032740biological_processpositive regulation of interleukin-17 production
A0032755biological_processpositive regulation of interleukin-6 production
A0032760biological_processpositive regulation of tumor necrosis factor production
A0032801biological_processreceptor catabolic process
A0032930biological_processpositive regulation of superoxide anion generation
A0032943biological_processmononuclear cell proliferation
A0032956biological_processregulation of actin cytoskeleton organization
A0032967biological_processpositive regulation of collagen biosynthetic process
A0034713molecular_functiontype I transforming growth factor beta receptor binding
A0034714molecular_functiontype III transforming growth factor beta receptor binding
A0035800molecular_functiondeubiquitinase activator activity
A0042098biological_processT cell proliferation
A0042110biological_processT cell activation
A0042127biological_processregulation of cell population proliferation
A0042130biological_processnegative regulation of T cell proliferation
A0042306biological_processregulation of protein import into nucleus
A0042307biological_processpositive regulation of protein import into nucleus
A0042482biological_processpositive regulation of odontogenesis
A0042802molecular_functionidentical protein binding
A0043029biological_processT cell homeostasis
A0043117biological_processpositive regulation of vascular permeability
A0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
A0043129biological_processsurfactant homeostasis
A0043410biological_processpositive regulation of MAPK cascade
A0043536biological_processpositive regulation of blood vessel endothelial cell migration
A0043537biological_processnegative regulation of blood vessel endothelial cell migration
A0043539molecular_functionprotein serine/threonine kinase activator activity
A0045066biological_processregulatory T cell differentiation
A0045216biological_processcell-cell junction organization
A0045589biological_processregulation of regulatory T cell differentiation
A0045591biological_processpositive regulation of regulatory T cell differentiation
A0045596biological_processnegative regulation of cell differentiation
A0045599biological_processnegative regulation of fat cell differentiation
A0045662biological_processnegative regulation of myoblast differentiation
A0045742biological_processpositive regulation of epidermal growth factor receptor signaling pathway
A0045786biological_processnegative regulation of cell cycle
A0045892biological_processnegative regulation of DNA-templated transcription
A0045893biological_processpositive regulation of DNA-templated transcription
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0046716biological_processmuscle cell cellular homeostasis
A0048146biological_processpositive regulation of fibroblast proliferation
A0048286biological_processlung alveolus development
A0048298biological_processpositive regulation of isotype switching to IgA isotypes
A0048535biological_processlymph node development
A0048642biological_processnegative regulation of skeletal muscle tissue development
A0048661biological_processpositive regulation of smooth muscle cell proliferation
A0050673biological_processepithelial cell proliferation
A0050680biological_processnegative regulation of epithelial cell proliferation
A0050714biological_processpositive regulation of protein secretion
A0050729biological_processpositive regulation of inflammatory response
A0050868biological_processnegative regulation of T cell activation
A0050921biological_processpositive regulation of chemotaxis
A0051247biological_processpositive regulation of protein metabolic process
A0051402biological_processneuron apoptotic process
A0051726biological_processregulation of cell cycle
A0051781biological_processpositive regulation of cell division
A0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A0055010biological_processventricular cardiac muscle tissue morphogenesis
A0055091biological_processphospholipid homeostasis
A0060070biological_processcanonical Wnt signaling pathway
A0060325biological_processface morphogenesis
A0060391biological_processpositive regulation of SMAD protein signal transduction
A0060435biological_processbronchiole development
A0060744biological_processmammary gland branching involved in thelarche
A0060751biological_processbranch elongation involved in mammary gland duct branching
A0060762biological_processregulation of branching involved in mammary gland duct morphogenesis
A0061035biological_processregulation of cartilage development
A0061298biological_processretina vasculature development in camera-type eye
A0061448biological_processconnective tissue development
A0061520biological_processLangerhans cell differentiation
A0070168biological_processnegative regulation of biomineral tissue development
A0070173biological_processregulation of enamel mineralization
A0070306biological_processlens fiber cell differentiation
A0070374biological_processpositive regulation of ERK1 and ERK2 cascade
A0070723biological_processresponse to cholesterol
A0071363biological_processcellular response to growth factor stimulus
A0071404biological_processcellular response to low-density lipoprotein particle stimulus
A0071456biological_processcellular response to hypoxia
A0071479biological_processcellular response to ionizing radiation
A0071560biological_processcellular response to transforming growth factor beta stimulus
A0071895biological_processodontoblast differentiation
A0072089biological_processstem cell proliferation
A0072562cellular_componentblood microparticle
A0085029biological_processextracellular matrix assembly
A0090263biological_processpositive regulation of canonical Wnt signaling pathway
A0097191biological_processextrinsic apoptotic signaling pathway
A0098586biological_processcellular response to virus
A1900126biological_processnegative regulation of hyaluronan biosynthetic process
A1900182biological_processpositive regulation of protein localization to nucleus
A1901203biological_processpositive regulation of extracellular matrix assembly
A1902462biological_processpositive regulation of mesenchymal stem cell proliferation
A1902894biological_processnegative regulation of miRNA transcription
A1902895biological_processpositive regulation of miRNA transcription
A1903077biological_processnegative regulation of protein localization to plasma membrane
A1904018biological_processpositive regulation of vasculature development
A1904894biological_processpositive regulation of receptor signaling pathway via STAT
A1990402biological_processembryonic liver development
A2000048biological_processnegative regulation of cell-cell adhesion mediated by cadherin
A2000343biological_processpositive regulation of chemokine (C-X-C motif) ligand 2 production
A2000353biological_processpositive regulation of endothelial cell apoptotic process
A2000636biological_processpositive regulation of primary miRNA processing
A2000648biological_processpositive regulation of stem cell proliferation
A2000727biological_processpositive regulation of cardiac muscle cell differentiation
B0000122biological_processnegative regulation of transcription by RNA polymerase II
B0000902biological_processcell morphogenesis
B0001570biological_processvasculogenesis
B0001657biological_processureteric bud development
B0001775biological_processcell activation
B0001837biological_processepithelial to mesenchymal transition
B0001843biological_processneural tube closure
B0002028biological_processregulation of sodium ion transport
B0002040biological_processsprouting angiogenesis
B0002062biological_processchondrocyte differentiation
B0002069biological_processcolumnar/cuboidal epithelial cell maturation
B0002244biological_processhematopoietic progenitor cell differentiation
B0002460biological_processadaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
B0002513biological_processtolerance induction to self antigen
B0002859biological_processnegative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
B0003179biological_processheart valve morphogenesis
B0003180biological_processaortic valve morphogenesis
B0005114molecular_functiontype II transforming growth factor beta receptor binding
B0005125molecular_functioncytokine activity
B0005160molecular_functiontransforming growth factor beta receptor binding
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005902cellular_componentmicrovillus
B0006611biological_processprotein export from nucleus
B0006754biological_processATP biosynthetic process
B0006796biological_processphosphate-containing compound metabolic process
B0006874biological_processintracellular calcium ion homeostasis
B0006954biological_processinflammatory response
B0007179biological_processtransforming growth factor beta receptor signaling pathway
B0007219biological_processNotch signaling pathway
B0007435biological_processsalivary gland morphogenesis
B0007492biological_processendoderm development
B0007507biological_processheart development
B0008083molecular_functiongrowth factor activity
B0008283biological_processcell population proliferation
B0008284biological_processpositive regulation of cell population proliferation
B0008285biological_processnegative regulation of cell population proliferation
B0008354biological_processgerm cell migration
B0009611biological_processresponse to wounding
B0009986cellular_componentcell surface
B0010467biological_processgene expression
B0010468biological_processregulation of gene expression
B0010628biological_processpositive regulation of gene expression
B0010629biological_processnegative regulation of gene expression
B0010718biological_processpositive regulation of epithelial to mesenchymal transition
B0010763biological_processpositive regulation of fibroblast migration
B0010936biological_processnegative regulation of macrophage cytokine production
B0014003biological_processoligodendrocyte development
B0014008biological_processpositive regulation of microglia differentiation
B0016202biological_processregulation of striated muscle tissue development
B0019899molecular_functionenzyme binding
B0021915biological_processneural tube development
B0030214biological_processhyaluronan catabolic process
B0030217biological_processT cell differentiation
B0030279biological_processnegative regulation of ossification
B0030308biological_processnegative regulation of cell growth
B0030316biological_processosteoclast differentiation
B0030335biological_processpositive regulation of cell migration
B0030879biological_processmammary gland development
B0031012cellular_componentextracellular matrix
B0031293biological_processmembrane protein intracellular domain proteolysis
B0031334biological_processpositive regulation of protein-containing complex assembly
B0032355biological_processresponse to estradiol
B0032570biological_processresponse to progesterone
B0032667biological_processregulation of interleukin-23 production
B0032700biological_processnegative regulation of interleukin-17 production
B0032740biological_processpositive regulation of interleukin-17 production
B0032755biological_processpositive regulation of interleukin-6 production
B0032760biological_processpositive regulation of tumor necrosis factor production
B0032801biological_processreceptor catabolic process
B0032930biological_processpositive regulation of superoxide anion generation
B0032943biological_processmononuclear cell proliferation
B0032956biological_processregulation of actin cytoskeleton organization
B0032967biological_processpositive regulation of collagen biosynthetic process
B0034713molecular_functiontype I transforming growth factor beta receptor binding
B0034714molecular_functiontype III transforming growth factor beta receptor binding
B0035800molecular_functiondeubiquitinase activator activity
B0042098biological_processT cell proliferation
B0042110biological_processT cell activation
B0042127biological_processregulation of cell population proliferation
B0042130biological_processnegative regulation of T cell proliferation
B0042306biological_processregulation of protein import into nucleus
B0042307biological_processpositive regulation of protein import into nucleus
B0042482biological_processpositive regulation of odontogenesis
B0042802molecular_functionidentical protein binding
B0043029biological_processT cell homeostasis
B0043117biological_processpositive regulation of vascular permeability
B0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
B0043129biological_processsurfactant homeostasis
B0043410biological_processpositive regulation of MAPK cascade
B0043536biological_processpositive regulation of blood vessel endothelial cell migration
B0043537biological_processnegative regulation of blood vessel endothelial cell migration
B0043539molecular_functionprotein serine/threonine kinase activator activity
B0045066biological_processregulatory T cell differentiation
B0045216biological_processcell-cell junction organization
B0045589biological_processregulation of regulatory T cell differentiation
B0045591biological_processpositive regulation of regulatory T cell differentiation
B0045596biological_processnegative regulation of cell differentiation
B0045599biological_processnegative regulation of fat cell differentiation
B0045662biological_processnegative regulation of myoblast differentiation
B0045742biological_processpositive regulation of epidermal growth factor receptor signaling pathway
B0045786biological_processnegative regulation of cell cycle
B0045892biological_processnegative regulation of DNA-templated transcription
B0045893biological_processpositive regulation of DNA-templated transcription
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0046716biological_processmuscle cell cellular homeostasis
B0048146biological_processpositive regulation of fibroblast proliferation
B0048286biological_processlung alveolus development
B0048298biological_processpositive regulation of isotype switching to IgA isotypes
B0048535biological_processlymph node development
B0048642biological_processnegative regulation of skeletal muscle tissue development
B0048661biological_processpositive regulation of smooth muscle cell proliferation
B0050673biological_processepithelial cell proliferation
B0050680biological_processnegative regulation of epithelial cell proliferation
B0050714biological_processpositive regulation of protein secretion
B0050729biological_processpositive regulation of inflammatory response
B0050868biological_processnegative regulation of T cell activation
B0050921biological_processpositive regulation of chemotaxis
B0051247biological_processpositive regulation of protein metabolic process
B0051402biological_processneuron apoptotic process
B0051726biological_processregulation of cell cycle
B0051781biological_processpositive regulation of cell division
B0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
B0055010biological_processventricular cardiac muscle tissue morphogenesis
B0055091biological_processphospholipid homeostasis
B0060070biological_processcanonical Wnt signaling pathway
B0060325biological_processface morphogenesis
B0060391biological_processpositive regulation of SMAD protein signal transduction
B0060435biological_processbronchiole development
B0060744biological_processmammary gland branching involved in thelarche
B0060751biological_processbranch elongation involved in mammary gland duct branching
B0060762biological_processregulation of branching involved in mammary gland duct morphogenesis
B0061035biological_processregulation of cartilage development
B0061298biological_processretina vasculature development in camera-type eye
B0061448biological_processconnective tissue development
B0061520biological_processLangerhans cell differentiation
B0070168biological_processnegative regulation of biomineral tissue development
B0070173biological_processregulation of enamel mineralization
B0070306biological_processlens fiber cell differentiation
B0070374biological_processpositive regulation of ERK1 and ERK2 cascade
B0070723biological_processresponse to cholesterol
B0071363biological_processcellular response to growth factor stimulus
B0071404biological_processcellular response to low-density lipoprotein particle stimulus
B0071456biological_processcellular response to hypoxia
B0071479biological_processcellular response to ionizing radiation
B0071560biological_processcellular response to transforming growth factor beta stimulus
B0071895biological_processodontoblast differentiation
B0072089biological_processstem cell proliferation
B0072562cellular_componentblood microparticle
B0085029biological_processextracellular matrix assembly
B0090263biological_processpositive regulation of canonical Wnt signaling pathway
B0097191biological_processextrinsic apoptotic signaling pathway
B0098586biological_processcellular response to virus
B1900126biological_processnegative regulation of hyaluronan biosynthetic process
B1900182biological_processpositive regulation of protein localization to nucleus
B1901203biological_processpositive regulation of extracellular matrix assembly
B1902462biological_processpositive regulation of mesenchymal stem cell proliferation
B1902894biological_processnegative regulation of miRNA transcription
B1902895biological_processpositive regulation of miRNA transcription
B1903077biological_processnegative regulation of protein localization to plasma membrane
B1904018biological_processpositive regulation of vasculature development
B1904894biological_processpositive regulation of receptor signaling pathway via STAT
B1990402biological_processembryonic liver development
B2000048biological_processnegative regulation of cell-cell adhesion mediated by cadherin
B2000343biological_processpositive regulation of chemokine (C-X-C motif) ligand 2 production
B2000353biological_processpositive regulation of endothelial cell apoptotic process
B2000636biological_processpositive regulation of primary miRNA processing
B2000648biological_processpositive regulation of stem cell proliferation
B2000727biological_processpositive regulation of cardiac muscle cell differentiation
C0000122biological_processnegative regulation of transcription by RNA polymerase II
C0000902biological_processcell morphogenesis
C0001570biological_processvasculogenesis
C0001657biological_processureteric bud development
C0001775biological_processcell activation
C0001837biological_processepithelial to mesenchymal transition
C0001843biological_processneural tube closure
C0002028biological_processregulation of sodium ion transport
C0002040biological_processsprouting angiogenesis
C0002062biological_processchondrocyte differentiation
C0002069biological_processcolumnar/cuboidal epithelial cell maturation
C0002244biological_processhematopoietic progenitor cell differentiation
C0002460biological_processadaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
C0002513biological_processtolerance induction to self antigen
C0002859biological_processnegative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
C0003179biological_processheart valve morphogenesis
C0003180biological_processaortic valve morphogenesis
C0005114molecular_functiontype II transforming growth factor beta receptor binding
C0005125molecular_functioncytokine activity
C0005160molecular_functiontransforming growth factor beta receptor binding
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005902cellular_componentmicrovillus
C0006611biological_processprotein export from nucleus
C0006754biological_processATP biosynthetic process
C0006796biological_processphosphate-containing compound metabolic process
C0006874biological_processintracellular calcium ion homeostasis
C0006954biological_processinflammatory response
C0007179biological_processtransforming growth factor beta receptor signaling pathway
C0007219biological_processNotch signaling pathway
C0007435biological_processsalivary gland morphogenesis
C0007492biological_processendoderm development
C0007507biological_processheart development
C0008083molecular_functiongrowth factor activity
C0008283biological_processcell population proliferation
C0008284biological_processpositive regulation of cell population proliferation
C0008285biological_processnegative regulation of cell population proliferation
C0008354biological_processgerm cell migration
C0009611biological_processresponse to wounding
C0009986cellular_componentcell surface
C0010467biological_processgene expression
C0010468biological_processregulation of gene expression
C0010628biological_processpositive regulation of gene expression
C0010629biological_processnegative regulation of gene expression
C0010718biological_processpositive regulation of epithelial to mesenchymal transition
C0010763biological_processpositive regulation of fibroblast migration
C0010936biological_processnegative regulation of macrophage cytokine production
C0014003biological_processoligodendrocyte development
C0014008biological_processpositive regulation of microglia differentiation
C0016202biological_processregulation of striated muscle tissue development
C0019899molecular_functionenzyme binding
C0021915biological_processneural tube development
C0030214biological_processhyaluronan catabolic process
C0030217biological_processT cell differentiation
C0030279biological_processnegative regulation of ossification
C0030308biological_processnegative regulation of cell growth
C0030316biological_processosteoclast differentiation
C0030335biological_processpositive regulation of cell migration
C0030879biological_processmammary gland development
C0031012cellular_componentextracellular matrix
C0031293biological_processmembrane protein intracellular domain proteolysis
C0031334biological_processpositive regulation of protein-containing complex assembly
C0032355biological_processresponse to estradiol
C0032570biological_processresponse to progesterone
C0032667biological_processregulation of interleukin-23 production
C0032700biological_processnegative regulation of interleukin-17 production
C0032740biological_processpositive regulation of interleukin-17 production
C0032755biological_processpositive regulation of interleukin-6 production
C0032760biological_processpositive regulation of tumor necrosis factor production
C0032801biological_processreceptor catabolic process
C0032930biological_processpositive regulation of superoxide anion generation
C0032943biological_processmononuclear cell proliferation
C0032956biological_processregulation of actin cytoskeleton organization
C0032967biological_processpositive regulation of collagen biosynthetic process
C0034713molecular_functiontype I transforming growth factor beta receptor binding
C0034714molecular_functiontype III transforming growth factor beta receptor binding
C0035800molecular_functiondeubiquitinase activator activity
C0042098biological_processT cell proliferation
C0042110biological_processT cell activation
C0042127biological_processregulation of cell population proliferation
C0042130biological_processnegative regulation of T cell proliferation
C0042306biological_processregulation of protein import into nucleus
C0042307biological_processpositive regulation of protein import into nucleus
C0042482biological_processpositive regulation of odontogenesis
C0042802molecular_functionidentical protein binding
C0043029biological_processT cell homeostasis
C0043117biological_processpositive regulation of vascular permeability
C0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
C0043129biological_processsurfactant homeostasis
C0043410biological_processpositive regulation of MAPK cascade
C0043536biological_processpositive regulation of blood vessel endothelial cell migration
C0043537biological_processnegative regulation of blood vessel endothelial cell migration
C0043539molecular_functionprotein serine/threonine kinase activator activity
C0045066biological_processregulatory T cell differentiation
C0045216biological_processcell-cell junction organization
C0045589biological_processregulation of regulatory T cell differentiation
C0045591biological_processpositive regulation of regulatory T cell differentiation
C0045596biological_processnegative regulation of cell differentiation
C0045599biological_processnegative regulation of fat cell differentiation
C0045662biological_processnegative regulation of myoblast differentiation
C0045742biological_processpositive regulation of epidermal growth factor receptor signaling pathway
C0045786biological_processnegative regulation of cell cycle
C0045892biological_processnegative regulation of DNA-templated transcription
C0045893biological_processpositive regulation of DNA-templated transcription
C0045944biological_processpositive regulation of transcription by RNA polymerase II
C0046716biological_processmuscle cell cellular homeostasis
C0048146biological_processpositive regulation of fibroblast proliferation
C0048286biological_processlung alveolus development
C0048298biological_processpositive regulation of isotype switching to IgA isotypes
C0048535biological_processlymph node development
C0048642biological_processnegative regulation of skeletal muscle tissue development
C0048661biological_processpositive regulation of smooth muscle cell proliferation
C0050673biological_processepithelial cell proliferation
C0050680biological_processnegative regulation of epithelial cell proliferation
C0050714biological_processpositive regulation of protein secretion
C0050729biological_processpositive regulation of inflammatory response
C0050868biological_processnegative regulation of T cell activation
C0050921biological_processpositive regulation of chemotaxis
C0051247biological_processpositive regulation of protein metabolic process
C0051402biological_processneuron apoptotic process
C0051726biological_processregulation of cell cycle
C0051781biological_processpositive regulation of cell division
C0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
C0055010biological_processventricular cardiac muscle tissue morphogenesis
C0055091biological_processphospholipid homeostasis
C0060070biological_processcanonical Wnt signaling pathway
C0060325biological_processface morphogenesis
C0060391biological_processpositive regulation of SMAD protein signal transduction
C0060435biological_processbronchiole development
C0060744biological_processmammary gland branching involved in thelarche
C0060751biological_processbranch elongation involved in mammary gland duct branching
C0060762biological_processregulation of branching involved in mammary gland duct morphogenesis
C0061035biological_processregulation of cartilage development
C0061298biological_processretina vasculature development in camera-type eye
C0061448biological_processconnective tissue development
C0061520biological_processLangerhans cell differentiation
C0070168biological_processnegative regulation of biomineral tissue development
C0070173biological_processregulation of enamel mineralization
C0070306biological_processlens fiber cell differentiation
C0070374biological_processpositive regulation of ERK1 and ERK2 cascade
C0070723biological_processresponse to cholesterol
C0071363biological_processcellular response to growth factor stimulus
C0071404biological_processcellular response to low-density lipoprotein particle stimulus
C0071456biological_processcellular response to hypoxia
C0071479biological_processcellular response to ionizing radiation
C0071560biological_processcellular response to transforming growth factor beta stimulus
C0071895biological_processodontoblast differentiation
C0072089biological_processstem cell proliferation
C0072562cellular_componentblood microparticle
C0085029biological_processextracellular matrix assembly
C0090263biological_processpositive regulation of canonical Wnt signaling pathway
C0097191biological_processextrinsic apoptotic signaling pathway
C0098586biological_processcellular response to virus
C1900126biological_processnegative regulation of hyaluronan biosynthetic process
C1900182biological_processpositive regulation of protein localization to nucleus
C1901203biological_processpositive regulation of extracellular matrix assembly
C1902462biological_processpositive regulation of mesenchymal stem cell proliferation
C1902894biological_processnegative regulation of miRNA transcription
C1902895biological_processpositive regulation of miRNA transcription
C1903077biological_processnegative regulation of protein localization to plasma membrane
C1904018biological_processpositive regulation of vasculature development
C1904894biological_processpositive regulation of receptor signaling pathway via STAT
C1990402biological_processembryonic liver development
C2000048biological_processnegative regulation of cell-cell adhesion mediated by cadherin
C2000343biological_processpositive regulation of chemokine (C-X-C motif) ligand 2 production
C2000353biological_processpositive regulation of endothelial cell apoptotic process
C2000636biological_processpositive regulation of primary miRNA processing
C2000648biological_processpositive regulation of stem cell proliferation
C2000727biological_processpositive regulation of cardiac muscle cell differentiation
D0000122biological_processnegative regulation of transcription by RNA polymerase II
D0000902biological_processcell morphogenesis
D0001570biological_processvasculogenesis
D0001657biological_processureteric bud development
D0001775biological_processcell activation
D0001837biological_processepithelial to mesenchymal transition
D0001843biological_processneural tube closure
D0002028biological_processregulation of sodium ion transport
D0002040biological_processsprouting angiogenesis
D0002062biological_processchondrocyte differentiation
D0002069biological_processcolumnar/cuboidal epithelial cell maturation
D0002244biological_processhematopoietic progenitor cell differentiation
D0002460biological_processadaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
D0002513biological_processtolerance induction to self antigen
D0002859biological_processnegative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
D0003179biological_processheart valve morphogenesis
D0003180biological_processaortic valve morphogenesis
D0005114molecular_functiontype II transforming growth factor beta receptor binding
D0005125molecular_functioncytokine activity
D0005160molecular_functiontransforming growth factor beta receptor binding
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005902cellular_componentmicrovillus
D0006611biological_processprotein export from nucleus
D0006754biological_processATP biosynthetic process
D0006796biological_processphosphate-containing compound metabolic process
D0006874biological_processintracellular calcium ion homeostasis
D0006954biological_processinflammatory response
D0007179biological_processtransforming growth factor beta receptor signaling pathway
D0007219biological_processNotch signaling pathway
D0007435biological_processsalivary gland morphogenesis
D0007492biological_processendoderm development
D0007507biological_processheart development
D0008083molecular_functiongrowth factor activity
D0008283biological_processcell population proliferation
D0008284biological_processpositive regulation of cell population proliferation
D0008285biological_processnegative regulation of cell population proliferation
D0008354biological_processgerm cell migration
D0009611biological_processresponse to wounding
D0009986cellular_componentcell surface
D0010467biological_processgene expression
D0010468biological_processregulation of gene expression
D0010628biological_processpositive regulation of gene expression
D0010629biological_processnegative regulation of gene expression
D0010718biological_processpositive regulation of epithelial to mesenchymal transition
D0010763biological_processpositive regulation of fibroblast migration
D0010936biological_processnegative regulation of macrophage cytokine production
D0014003biological_processoligodendrocyte development
D0014008biological_processpositive regulation of microglia differentiation
D0016202biological_processregulation of striated muscle tissue development
D0019899molecular_functionenzyme binding
D0021915biological_processneural tube development
D0030214biological_processhyaluronan catabolic process
D0030217biological_processT cell differentiation
D0030279biological_processnegative regulation of ossification
D0030308biological_processnegative regulation of cell growth
D0030316biological_processosteoclast differentiation
D0030335biological_processpositive regulation of cell migration
D0030879biological_processmammary gland development
D0031012cellular_componentextracellular matrix
D0031293biological_processmembrane protein intracellular domain proteolysis
D0031334biological_processpositive regulation of protein-containing complex assembly
D0032355biological_processresponse to estradiol
D0032570biological_processresponse to progesterone
D0032667biological_processregulation of interleukin-23 production
D0032700biological_processnegative regulation of interleukin-17 production
D0032740biological_processpositive regulation of interleukin-17 production
D0032755biological_processpositive regulation of interleukin-6 production
D0032760biological_processpositive regulation of tumor necrosis factor production
D0032801biological_processreceptor catabolic process
D0032930biological_processpositive regulation of superoxide anion generation
D0032943biological_processmononuclear cell proliferation
D0032956biological_processregulation of actin cytoskeleton organization
D0032967biological_processpositive regulation of collagen biosynthetic process
D0034713molecular_functiontype I transforming growth factor beta receptor binding
D0034714molecular_functiontype III transforming growth factor beta receptor binding
D0035800molecular_functiondeubiquitinase activator activity
D0042098biological_processT cell proliferation
D0042110biological_processT cell activation
D0042127biological_processregulation of cell population proliferation
D0042130biological_processnegative regulation of T cell proliferation
D0042306biological_processregulation of protein import into nucleus
D0042307biological_processpositive regulation of protein import into nucleus
D0042482biological_processpositive regulation of odontogenesis
D0042802molecular_functionidentical protein binding
D0043029biological_processT cell homeostasis
D0043117biological_processpositive regulation of vascular permeability
D0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
D0043129biological_processsurfactant homeostasis
D0043410biological_processpositive regulation of MAPK cascade
D0043536biological_processpositive regulation of blood vessel endothelial cell migration
D0043537biological_processnegative regulation of blood vessel endothelial cell migration
D0043539molecular_functionprotein serine/threonine kinase activator activity
D0045066biological_processregulatory T cell differentiation
D0045216biological_processcell-cell junction organization
D0045589biological_processregulation of regulatory T cell differentiation
D0045591biological_processpositive regulation of regulatory T cell differentiation
D0045596biological_processnegative regulation of cell differentiation
D0045599biological_processnegative regulation of fat cell differentiation
D0045662biological_processnegative regulation of myoblast differentiation
D0045742biological_processpositive regulation of epidermal growth factor receptor signaling pathway
D0045786biological_processnegative regulation of cell cycle
D0045892biological_processnegative regulation of DNA-templated transcription
D0045893biological_processpositive regulation of DNA-templated transcription
D0045944biological_processpositive regulation of transcription by RNA polymerase II
D0046716biological_processmuscle cell cellular homeostasis
D0048146biological_processpositive regulation of fibroblast proliferation
D0048286biological_processlung alveolus development
D0048298biological_processpositive regulation of isotype switching to IgA isotypes
D0048535biological_processlymph node development
D0048642biological_processnegative regulation of skeletal muscle tissue development
D0048661biological_processpositive regulation of smooth muscle cell proliferation
D0050673biological_processepithelial cell proliferation
D0050680biological_processnegative regulation of epithelial cell proliferation
D0050714biological_processpositive regulation of protein secretion
D0050729biological_processpositive regulation of inflammatory response
D0050868biological_processnegative regulation of T cell activation
D0050921biological_processpositive regulation of chemotaxis
D0051247biological_processpositive regulation of protein metabolic process
D0051402biological_processneuron apoptotic process
D0051726biological_processregulation of cell cycle
D0051781biological_processpositive regulation of cell division
D0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
D0055010biological_processventricular cardiac muscle tissue morphogenesis
D0055091biological_processphospholipid homeostasis
D0060070biological_processcanonical Wnt signaling pathway
D0060325biological_processface morphogenesis
D0060391biological_processpositive regulation of SMAD protein signal transduction
D0060435biological_processbronchiole development
D0060744biological_processmammary gland branching involved in thelarche
D0060751biological_processbranch elongation involved in mammary gland duct branching
D0060762biological_processregulation of branching involved in mammary gland duct morphogenesis
D0061035biological_processregulation of cartilage development
D0061298biological_processretina vasculature development in camera-type eye
D0061448biological_processconnective tissue development
D0061520biological_processLangerhans cell differentiation
D0070168biological_processnegative regulation of biomineral tissue development
D0070173biological_processregulation of enamel mineralization
D0070306biological_processlens fiber cell differentiation
D0070374biological_processpositive regulation of ERK1 and ERK2 cascade
D0070723biological_processresponse to cholesterol
D0071363biological_processcellular response to growth factor stimulus
D0071404biological_processcellular response to low-density lipoprotein particle stimulus
D0071456biological_processcellular response to hypoxia
D0071479biological_processcellular response to ionizing radiation
D0071560biological_processcellular response to transforming growth factor beta stimulus
D0071895biological_processodontoblast differentiation
D0072089biological_processstem cell proliferation
D0072562cellular_componentblood microparticle
D0085029biological_processextracellular matrix assembly
D0090263biological_processpositive regulation of canonical Wnt signaling pathway
D0097191biological_processextrinsic apoptotic signaling pathway
D0098586biological_processcellular response to virus
D1900126biological_processnegative regulation of hyaluronan biosynthetic process
D1900182biological_processpositive regulation of protein localization to nucleus
D1901203biological_processpositive regulation of extracellular matrix assembly
D1902462biological_processpositive regulation of mesenchymal stem cell proliferation
D1902894biological_processnegative regulation of miRNA transcription
D1902895biological_processpositive regulation of miRNA transcription
D1903077biological_processnegative regulation of protein localization to plasma membrane
D1904018biological_processpositive regulation of vasculature development
D1904894biological_processpositive regulation of receptor signaling pathway via STAT
D1990402biological_processembryonic liver development
D2000048biological_processnegative regulation of cell-cell adhesion mediated by cadherin
D2000343biological_processpositive regulation of chemokine (C-X-C motif) ligand 2 production
D2000353biological_processpositive regulation of endothelial cell apoptotic process
D2000636biological_processpositive regulation of primary miRNA processing
D2000648biological_processpositive regulation of stem cell proliferation
D2000727biological_processpositive regulation of cardiac muscle cell differentiation
Functional Information from PROSITE/UniProt
site_idPS00250
Number of Residues16
DetailsTGF_BETA_1 TGF-beta family signature. IhePkgYhanfClGpC
ChainResidueDetails
AILE282-CYS297

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsSITE: Cleavage; by FURIN => ECO:0000250|UniProtKB:P01137
ChainResidueDetails
AARG249
BARG249
CARG249
DARG249

site_idSWS_FT_FI2
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:21677751, ECO:0007744|PDB:5VQF
ChainResidueDetails
AASN53
BASN53
CASN53
DASN53

site_idSWS_FT_FI3
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:21677751
ChainResidueDetails
AASN107
BASN107
CASN107
DASN107

site_idSWS_FT_FI4
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AGLN147
BGLN147
CGLN147
DGLN147

237735

PDB entries from 2025-06-18

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