5MR4

Ligand-receptor complex.

Summary for 5MR4

Related5MR4 5MR5 5NMZ
DescriptorNeurturin, GDNF family receptor alpha-2, DI(HYDROXYETHYL)ETHER, ... (5 entities in total)
Functional Keywordscomplex, signalling, receptor, signaling protein
Biological sourceHomo sapiens (Human)
Cellular locationSecreted Q99748
Cell membrane ; Lipid-anchor, GPI-anchor  O00451
Total number of polymer chains4
Total molecular weight125522.36
Authors
Sandmark, J.,Oster, L.,Aagaard, A.,Roth, R.G.,Dahl, G. (deposition date: 2016-12-21, release date: 2018-01-17, Last modification date: 2018-04-25)
Primary citation
Sandmark, J.,Dahl, G.,Oster, L.,Xu, B.,Johansson, P.,Akerud, T.,Aagaard, A.,Davidsson, P.,Bigalke, J.M.,Winzell, M.S.,Rainey, G.J.,Roth, R.G.
Structure and biophysical characterization of the human full-length neurturin-GFRa2 complex: A role for heparan sulfate in signaling.
J. Biol. Chem., 293:5492-5508, 2018
PubMed: 29414779 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.RA117.000820
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.4 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.22140.1%5.3%8.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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Molmil generated image of 5mr4
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Molmil generated image of 5mr4
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