PDB: 435 resultsInfo pagesStatus searchChemie searchBIRD

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4IUZ	High resolution crystal structure of racemic ester insulin Descriptor: DI(HYDROXYETHYL)ETHER, GLYCEROL, Insulin A chain, ... Authors: Avital-Shmilovici, M, Mandal, K, Gates, Z.P, Phillips, N, Weiss, M.A, Kent, S.B.H. Deposit date: 2013-01-22 Release date: 2013-02-13 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Fully Convergent Chemical Synthesis of Ester Insulin: Determination of the High Resolution X-ray Structure by Racemic Protein Crystallography. J.Am.Chem.Soc., 135, 2013
4IYF	Insulin glargine crystal structure 2 Descriptor: Insulin A chain, Insulin B chain Authors: Barba de la Rosa, A.P, Lara-Gonzalez, S, Montero-Moran, G.M, Escobedo-Moratilla, A. Deposit date: 2013-01-28 Release date: 2014-02-12 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Physicochemical and structural analysis of a biosimilar insulin glargine formulation and its reference to be published
3KR3	Crystal structure of IGF-II antibody complex Descriptor: 1,2-ETHANEDIOL, Insulin-like growth factor II, antibody-Fab (heavy chain), ... Authors: Peat, T.S, Newman, J, Adams, T.E. Deposit date: 2009-11-17 Release date: 2010-06-16 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (2.2 Å) Cite: A human monoclonal antibody against insulin-like growth factor-II blocks the growth of human hepatocellular carcinoma cell lines in vitro and in vivo. Mol.Cancer Ther., 9, 2010
3KQ6	Enhancing the Therapeutic Properties of a Protein by a Designed Zinc-Binding Site, Structural principles of a novel long-acting insulin analog Descriptor: CHLORIDE ION, Insulin A chain, Insulin B chain, ... Authors: Wan, Z.L, Hu, S.Q, Whittaker, L, Phillips, N.B, Whittake, J, Ismail-Beigi, F, Weiss, M.A. Deposit date: 2009-11-17 Release date: 2010-02-23 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Supramolecular protein engineering: design of zinc-stapled insulin hexamers as a long acting depot. J.Biol.Chem., 285, 2010
3LRI	Solution structure and backbone dynamics of long-[Arg(3)]insulin-like growth factor-I Descriptor: PROTEIN (INSULIN-LIKE GROWTH FACTOR I) Authors: Laajoki, L.G, Francis, G.L, Wallace, J.C, Carver, J.A, Keniry, M.A. Deposit date: 1999-04-13 Release date: 2000-05-23 Last modified: 2023-12-27 Method: SOLUTION NMR Cite: Solution structure and backbone dynamics of long-[Arg(3)]insulin-like growth factor-I J.Biol.Chem., 275, 2000
3MTH	X-RAY CRYSTALLOGRAPHIC STUDIES ON HEXAMERIC INSULINS IN THE PRESENCE OF HELIX-STABILIZING AGENTS, THIOCYANATE, METHYLPARABEN AND PHENOL Descriptor: 4-HYDROXY-BENZOIC ACID METHYL ESTER, CHLORIDE ION, METHYLPARABEN INSULIN, ... Authors: Whittingham, J.L, Dodson, E.J, Moody, P.C.E, Dodson, G.G. Deposit date: 1995-09-13 Release date: 1996-01-29 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (1.9 Å) Cite: X-ray crystallographic studies on hexameric insulins in the presence of helix-stabilizing agents, thiocyanate, methylparaben, and phenol. Biochemistry, 34, 1995
4M4J	Radiation damage study of Cu T6-insulin - 0.30 MGy Descriptor: COPPER (II) ION, Insulin Authors: Frankaer, C.G, Harris, P, Stahl, K. Deposit date: 2013-08-07 Release date: 2014-01-15 Last modified: 2018-03-07 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Towards accurate structural characterization of metal centres in protein crystals: the structures of Ni and Cu T6 bovine insulin derivatives. Acta Crystallogr.,Sect.D, 70, 2014
2A3G	The structure of T6 bovine insulin Descriptor: Insulin, ZINC ION Authors: Smith, G.D, Pangborn, W.A, Blessing, R.H. Deposit date: 2005-06-24 Release date: 2005-10-25 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (2.25 Å) Cite: The structure of T6 bovine insulin. Acta Crystallogr.,Sect.D, 61, 2005
2AIY	R6 HUMAN INSULIN HEXAMER (SYMMETRIC), NMR, 20 STRUCTURES Descriptor: PHENOL, PROTEIN (INSULIN) Authors: O'Donoghue, S.I, Chang, X, Abseher, R, Nilges, M, Led, J.J. Deposit date: 1998-12-28 Release date: 2000-02-28 Last modified: 2023-12-27 Method: SOLUTION NMR Cite: Unraveling the symmetry ambiguity in a hexamer: calculation of the R6 human insulin structure. J.Biomol.NMR, 16, 2000
2BN3	Insulin before a high dose x-ray burn Descriptor: INSULIN Authors: Nanao, M.H, Ravelli, R.B. Deposit date: 2005-03-18 Release date: 2005-09-07 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Improving Radiation-Damage Substructures for Rip. Acta Crystallogr.,Sect.D, 61, 2005
2BN1	Insulin after a high dose x-ray burn Descriptor: INSULIN A CHAIN, INSULIN B CHAIN Authors: Nanao, M.H, Ravelli, R.B. Deposit date: 2005-03-18 Release date: 2005-09-07 Last modified: 2013-04-03 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Improving Radiation-Damage Substructures for Rip. Acta Crystallogr.,Sect.D, 61, 2005
2C8R	insuline(60sec) and UV laser excited fluorescence Descriptor: INSULIN A CHAIN, INSULIN B CHAIN Authors: Vernede, X, Lavault, B, Ohana, J, Nurizzo, D, Joly, J, Jacquamet, L, Felisaz, F, Cipriani, F, Bourgeois, D. Deposit date: 2005-12-06 Release date: 2006-03-08 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Uv Laser-Excited Fluorescence as a Tool for the Visualization of Protein Crystals Mounted in Loops. Acta Crystallogr.,Sect.D, 62, 2006
2C8Q	insuline(1sec) and UV laser excited fluorescence Descriptor: INSULIN A CHAIN, INSULIN B CHAIN Authors: Vernede, X, Lavault, B, Ohana, J, Nurizzo, D, Joly, J, Jacquamet, L, Felisaz, F, Cipriani, F, Bourgeois, D. Deposit date: 2005-12-06 Release date: 2006-03-08 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Uv Laser-Excited Fluorescence as a Tool for the Visualization of Protein Crystals Mounted in Loops. Acta Crystallogr.,Sect.D, 62, 2006
2EFA	Neutron crystal structure of cubic insulin at pD6.6 Descriptor: Insulin Authors: Ishikawa, T, Tanaka, I, Niimura, N. Deposit date: 2007-02-22 Release date: 2008-01-22 Last modified: 2023-10-25 Method: NEUTRON DIFFRACTION (2.7 Å) Cite: A neutron crystallographic analysis of a cubic porcine insulin at pD 6.6 Chem.Phys., 345, 2008
2G4M	Insulin collected at 2.0 A wavelength Descriptor: Insulin A chain, Insulin B chain Authors: Mueller-Dieckmann, C, Weiss, M.S. Deposit date: 2006-02-22 Release date: 2007-02-20 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (1.8 Å) Cite: On the routine use of soft X-rays in macromolecular crystallography. Part IV. Efficient determination of anomalous substructures in biomacromolecules using longer X-ray wavelengths. Acta Crystallogr.,Sect.D, 63, 2007
5T7R	A6-A11 trans-dicarba human insulin Descriptor: Insulin A chain, Insulin B chain Authors: Menting, J.G, Lawrence, M.C, Robinson, A.J, Forbes, B.E. Deposit date: 2016-09-05 Release date: 2017-12-06 Last modified: 2019-06-19 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Insulin in motion: The A6-A11 disulfide bond allosterically modulates structural transitions required for insulin activity. Sci Rep, 7, 2017
5UDP	High resolution x-ray crystal structure of synthetic insulin lispro Descriptor: CHLORIDE ION, Insulin Lispro A chain, Insulin Lispro B chain, ... Authors: Mandal, K, Dhayalan, B, Kent, S.B.H. Deposit date: 2016-12-28 Release date: 2017-01-11 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.348 Å) Cite: Scope and Limitations of Fmoc Chemistry SPPS-Based Approaches to the Total Synthesis of Insulin Lispro via Ester Insulin. Chemistry, 23, 2017
5USP	Insulin with proline analog Pip at position B28 in the T2 state Descriptor: Insulin Chain A, Insulin Chain B, SODIUM ION Authors: Lieblich, S.A, Fang, K.Y, Tirrell, D.A. Deposit date: 2017-02-13 Release date: 2018-02-21 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.174 Å) Cite: Insulin with proline analog Pip at position B28 in the T2 state To Be Published
5UU4	Insulin with proline analog ThioP at position B28 in the R6 state Descriptor: CHLORIDE ION, Insulin A Chain, Insulin B Chain, ... Authors: Lieblich, S.A, Fang, K.Y, Tirrell, D.A. Deposit date: 2017-02-16 Release date: 2018-02-21 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.973 Å) Cite: Insulin with proline analog ThioP at position B28 in the R6 state To Be Published
5USS	Insulin with proline analog PiP at position B28 in the R6 state Descriptor: CHLORIDE ION, Insulin Chain A, Insulin Chain B, ... Authors: Lieblich, S.A, Fang, K.Y, Tirrell, D.A. Deposit date: 2017-02-13 Release date: 2018-02-21 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.061 Å) Cite: Insulin with proline analog PiP at position B28 in the R6 state To Be Published
5UU2	Insulin with proline analog ThioP at position B28 in the T2 state Descriptor: Insulin Chain A, Insulin Chain B Authors: Lieblich, S.A, Fang, K.Y, Tirrell, D.A. Deposit date: 2017-02-15 Release date: 2018-02-21 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.223 Å) Cite: Insulin with proline analog ThioP at position B28 in the T2 state To Be Published
5USV	Insulin with proline analog AzeP at position B28 in the T2 state Descriptor: Insulin Chain A, Insulin Chain B, SODIUM ION Authors: Lieblich, S.A, Fang, K.Y, Tirrell, D.A. Deposit date: 2017-02-14 Release date: 2018-02-21 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.3 Å) Cite: Insulin with proline analog AzeP at position B28 in the T2 state To Be Published
5UOZ	Insulin with proline analog FyP at position B28 in the T2 state Descriptor: Insulin Chain A, Insulin Chain B Authors: Lieblich, S.A, Fang, K.Y, Tirrell, D.A. Deposit date: 2017-02-01 Release date: 2018-02-07 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.17463875 Å) Cite: Insulin with proline analog FyP at position B28 in the T2 state To Be Published
5URU	Insulin with proline analog DhP at position B28 in the R6 state Descriptor: CHLORIDE ION, Insulin Chain A, Insulin Chain B, ... Authors: Lieblich, S.A, Fang, K.Y, Tirrell, D.A. Deposit date: 2017-02-13 Release date: 2018-02-21 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.41 Å) Cite: Insulin with proline analog DhP at position B28 in the R6 state To Be Published
5UQA	Insulin with proline analog FzP at position B28 in the R6 state Descriptor: ACETONE, CHLORIDE ION, GLYCEROL, ... Authors: Lieblich, S.A, Fang, K.Y, Tirrell, D.A. Deposit date: 2017-02-07 Release date: 2018-02-21 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.31000245 Å) Cite: Insulin with proline analog FzP at position B28 in the R6 state To Be Published

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