Loading
PDBj
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help

1I7C
DownloadVisualize
BU of 1i7c by Molmil
HUMAN S-ADENOSYLMETHIONINE DECARBOXYLASE WITH COVALENTLY BOUND PYRUVOYL GROUP AND COMPLEXED WITH METHYLGLYOXAL BIS-(GUANYLHYDRAZONE)
Descriptor: 1,4-DIAMINOBUTANE, METHYLGLYOXAL BIS-(GUANYLHYDRAZONE), S-ADENOSYLMETHIONINE DECARBOXYLASE ALPHA CHAIN, ...
Authors:Tolbert, W.D, Ekstrom, J.L, Mathews, I.I, Secrist III, J.A, Pegg, A.E, Ealick, S.E.
Deposit date:2001-03-08
Release date:2001-08-22
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The structural basis for substrate specificity and inhibition of human S-adenosylmethionine decarboxylase.
Biochemistry, 40, 2001
5HJO
DownloadVisualize
BU of 5hjo by Molmil
Murine endoplasmic reticulum alpha-glucosidase II with bound substrate analogue
Descriptor: 1,2-ETHANEDIOL, 2-deoxy-alpha-D-arabino-hexopyranose-(1-3)-D-glucal, ACETATE ION, ...
Authors:Caputo, A.T, Roversi, P, Alonzi, D.S, Kiappes, J.L, Zitzmann, N.
Deposit date:2016-01-13
Release date:2016-07-27
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:Structures of mammalian ER alpha-glucosidase II capture the binding modes of broad-spectrum iminosugar antivirals.
Proc.Natl.Acad.Sci.USA, 113, 2016
1QR3
DownloadVisualize
BU of 1qr3 by Molmil
Structure of porcine pancreatic elastase in complex with FR901277, a novel macrocyclic inhibitor of elastases at 1.6 angstrom resolution
Descriptor: CALCIUM ION, Chymotrypsin-like elastase family member 1, FR901277 Inhibitor, ...
Authors:Nakanishi, I, Kinoshita, T, Sato, A, Tada, T.
Deposit date:1999-06-18
Release date:2000-06-21
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure of porcine pancreatic elastase complexed with FR901277, a novel macrocyclic inhibitor of elastases, at 1.6 A resolution.
Biopolymers, 53, 2000
3MAU
DownloadVisualize
BU of 3mau by Molmil
Crystal structure of StSPL in complex with phosphoethanolamine
Descriptor: (5-HYDROXY-4,6-DIMETHYLPYRIDIN-3-YL)METHYL DIHYDROGEN PHOSPHATE, PHOSPHATE ION, sphingosine-1-phosphate lyase, ...
Authors:Bourquin, F, Grutter, M.G, Capitani, G.
Deposit date:2010-03-24
Release date:2010-08-18
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure and Function of Sphingosine-1-Phosphate Lyase, a Key Enzyme of Sphingolipid Metabolism.
Structure, 18, 2010
3R0O
DownloadVisualize
BU of 3r0o by Molmil
Crystal structure of carnitinyl-CoA hydratase from Mycobacterium avium
Descriptor: 1,2-ETHANEDIOL, Carnitinyl-CoA dehydratase, GLYCEROL, ...
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2011-03-08
Release date:2011-03-16
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Increasing the structural coverage of tuberculosis drug targets.
Tuberculosis (Edinb), 95, 2015
1YHZ
DownloadVisualize
BU of 1yhz by Molmil
Crystal structure of Arabidopsis thaliana Acetohydroxyacid synthase In Complex With A Sulfonylurea Herbicide, Chlorsulfuron
Descriptor: 1-(2-CHLOROPHENYLSULFONYL)-3-(4-METHOXY-6-METHYL-L,3,5-TRIAZIN-2-YL)UREA, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, Acetolactate synthase, ...
Authors:McCourt, J.A, Pang, S.S, King-Scott, J, Guddat, L.W, Duggleby, R.G.
Deposit date:2005-01-10
Release date:2006-01-17
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Herbicide-binding sites revealed in the structure of plant acetohydroxyacid synthase
Proc.Natl.Acad.Sci.Usa, 103, 2006
4OCZ
DownloadVisualize
BU of 4ocz by Molmil
Crystal structure of human soluble epoxide hydrolase complexed with 1-(1-isobutyrylpiperidin-4-yl)-3-(4-(trifluoromethyl)phenyl)urea
Descriptor: 1-[1-(2-methylpropanoyl)piperidin-4-yl]-3-[4-(trifluoromethyl)phenyl]urea, Bifunctional epoxide hydrolase 2, MAGNESIUM ION, ...
Authors:Lee, K.S.S, Liu, J, Wagner, K.M, Pakhomova, S, Dong, H, Morriseau, C, Fu, S.H, Yang, J, Wang, P, Ulu, A, Mate, C, Nguyen, L, Wullf, H, Eldin, M.L, Mara, A.A, Newcomer, M.E, Zeldin, D.C, Hammock, B.D.
Deposit date:2014-01-09
Release date:2014-09-24
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.94 Å)
Cite:Optimized inhibitors of soluble epoxide hydrolase improve in vitro target residence time and in vivo efficacy.
J.Med.Chem., 57, 2014
4ONA
DownloadVisualize
BU of 4ona by Molmil
Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1517
Descriptor: 5-amino-1-tert-butyl-3-(7-ethoxyquinolin-3-yl)-1H-pyrazole-4-carboxamide, Calmodulin-domain protein kinase 1
Authors:Merritt, E.A.
Deposit date:2014-01-28
Release date:2014-03-19
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Potent and selective inhibitors of CDPK1 from T. gondii and C. parvum based on a 5-aminopyrazole-4-carboxamide scaffold.
ACS Med Chem Lett, 5, 2014
2JEP
DownloadVisualize
BU of 2jep by Molmil
Native family 5 xyloglucanase from Paenibacillus pabuli
Descriptor: 1,2-ETHANEDIOL, CALCIUM ION, XYLOGLUCANASE
Authors:Gloster, T.M, Ibatullin, F.M, Macauley, K, Eklof, J.M, Roberts, S, Turkenburg, J.P, Bjornvad, M.E, Jorgensen, P.L, Danielsen, S, Johansen, K, Borchert, T.V, Wilson, K.S, Brumer, H, Davies, G.J.
Deposit date:2007-01-18
Release date:2007-03-20
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Characterization and Three-Dimensional Structures of Two Distinct Bacterial Xyloglucanases from Families Gh5 and Gh12.
J.Biol.Chem., 282, 2007
3MSZ
DownloadVisualize
BU of 3msz by Molmil
Crystal Structure of Glutaredoxin 1 from Francisella tularensis Complexed with Cacodylate
Descriptor: CACODYLATE ION, GLUTATHIONE, GLYCEROL, ...
Authors:Maltseva, N, Kim, Y, Kwon, K, Anderson, W.F, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2010-04-29
Release date:2010-05-19
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.053 Å)
Cite:Crystal Structure of Glutaredoxin 1 from Francisella tularensis Complexed with Cacodylate
To be Published
4OLU
DownloadVisualize
BU of 4olu by Molmil
Crystal structure of antibody VRC07 in complex with clade A/E 93TH057 HIV-1 gp120 core
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Antigen binding fragment of heavy chain: Antibody VRC01, Antigen binding fragment of light chain: Antibody VRC01, ...
Authors:Kwon, Y.D, Kwong, P.D.
Deposit date:2014-01-25
Release date:2014-09-03
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (2.202 Å)
Cite:Enhanced Potency of a Broadly Neutralizing HIV-1 Antibody In Vitro Improves Protection against Lentiviral Infection In Vivo.
J.Virol., 88, 2014
3W8Q
DownloadVisualize
BU of 3w8q by Molmil
Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (MEK1)
Descriptor: Dual specificity mitogen-activated protein kinase kinase 1, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER
Authors:Nakae, S, Kitamura, M, Shirai, T, Tada, T.
Deposit date:2013-03-20
Release date:2014-03-26
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of mitogen-activated protein kinase kinase 1 in the DFG-out conformation.
Acta Crystallogr.,Sect.F, 77, 2021
2WGS
DownloadVisualize
BU of 2wgs by Molmil
Crystal structure of Mycobacterium Tuberculosis Glutamine Synthetase in complex with a purine analogue inhibitor.
Descriptor: 1-(3,4-dichlorobenzyl)-3,7-dimethyl-8-morpholin-4-yl-3,7-dihydro-1H-purine-2,6-dione, CHLORIDE ION, GLUTAMINE SYNTHETASE 1
Authors:Nilsson, M.T, Krajewski, W.W, Jones, T.A, Mowbray, S.L.
Deposit date:2009-04-27
Release date:2009-09-01
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Structural Basis for the Inhibition of Mycobacterium Tuberculosis Glutamine Synthetase by Novel ATP-Competitive Inhibitors.
J.Mol.Biol., 393, 2009
4OQ9
DownloadVisualize
BU of 4oq9 by Molmil
Satellite Tobacco Mosaic Virus Refined to 1.4 A Resolution using non-crystallographic symmetry restraints
Descriptor: Coat protein, MAGNESIUM ION, PHOSPHATE ION, ...
Authors:Larson, S.B, Day, J.S, McPherson, A.
Deposit date:2014-02-07
Release date:2014-09-10
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Satellite tobacco mosaic virus refined to 1.4 angstrom resolution.
Acta Crystallogr.,Sect.D, 70, 2014
3WE4
DownloadVisualize
BU of 3we4 by Molmil
Crystal structure of S6K1 kinase domain in complex with a pyrimidine derivative PF-4708671 2-{[4-(5-ethylpyrimidin-4-yl)piperazin-1-yl]methyl}-5-(trifluoromethyl)-1H-benzimidazole
Descriptor: 2-{[4-(5-ethylpyrimidin-4-yl)piperazin-1-yl]methyl}-5-(trifluoromethyl)-1H-benzimidazole, Ribosomal protein S6 kinase beta-1, ZINC ION
Authors:Niwa, H, Shirouzu, M, Yokoyama, S.
Deposit date:2013-06-29
Release date:2014-08-06
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (1.995 Å)
Cite:Crystal structures of the S6K1 kinase domain in complexes with inhibitors
J.Struct.Funct.Genom., 15, 2014
3MHS
DownloadVisualize
BU of 3mhs by Molmil
Structure of the SAGA Ubp8/Sgf11/Sus1/Sgf73 DUB module bound to ubiquitin aldehyde
Descriptor: 1,2-ETHANEDIOL, GLYCEROL, Protein SUS1, ...
Authors:Samara, N.L, Datta, A.B, Berndsen, C.E, Zhang, X, Yao, T, Cohen, R.E, Wolberger, C.
Deposit date:2010-04-08
Release date:2010-04-21
Last modified:2025-03-26
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Structural insights into the assembly and function of the SAGA deubiquitinating module.
Science, 328, 2010
5TZA
DownloadVisualize
BU of 5tza by Molmil
CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 2A WITH 3-{5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl-1-[(naphthalene-2-yl)carbonyl]piperidine
Descriptor: MAGNESIUM ION, ZINC ION, [(3S)-3-(5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)piperidin-1-yl](naphthalen-2-yl)methanone, ...
Authors:Xu, R, Aertgeerts, K.
Deposit date:2016-11-21
Release date:2017-02-22
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Design and Synthesis of Novel and Selective Phosphodiesterase 2 (PDE2a) Inhibitors for the Treatment of Memory Disorders.
J. Med. Chem., 60, 2017
3D14
DownloadVisualize
BU of 3d14 by Molmil
Crystal structure of mouse Aurora A (Asn186->Gly, Lys240->Arg, Met302->Leu) in complex with 1-{5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)-ethyl]- thiazol-2-yl}-3-(3-trifluoromethyl-phenyl)-urea
Descriptor: 1-{5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-1,3-thiazol-2-yl}-3-[3-(trifluoromethyl)phenyl]urea, serine/threonine kinase 6
Authors:Elling, R.A, Baskaran, S, Allen, D.A, Oslob, J.D, Romanowski, M.J.
Deposit date:2008-05-04
Release date:2008-08-26
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Discovery of a potent and selective aurora kinase inhibitor.
Bioorg.Med.Chem.Lett., 18, 2008
1E25
DownloadVisualize
BU of 1e25 by Molmil
The high resolution structure of PER-1 class A beta-lactamase
Descriptor: EXTENDED-SPECTRUM BETA-LACTAMASE PER-1, SULFATE ION
Authors:Tranier, S, Bouthors, A.T, Maveyraud, L, Guillet, V, Sougakoff, W, Samama, J.P.
Deposit date:2000-05-17
Release date:2000-11-06
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The High Resolution Crystal Structure for Class a Beta-Lactamase Per-1 Reveals the Bases for its Increase in Breadth of Activity
J.Biol.Chem., 275, 2000
1IG7
DownloadVisualize
BU of 1ig7 by Molmil
Msx-1 Homeodomain/DNA Complex Structure
Descriptor: 5'-D(*CP*AP*CP*TP*AP*AP*TP*TP*GP*AP*AP*GP*G)-3', 5'-D(P*TP*CP*CP*TP*TP*CP*AP*AP*TP*TP*AP*GP*TP*GP*AP*C)-3', Homeotic protein Msx-1
Authors:Hovde, S, Abate-Shen, C, Geiger, J.H.
Deposit date:2001-04-17
Release date:2001-04-23
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of the Msx-1 homeodomain/DNA complex
Biochemistry, 40, 2001
2OIB
DownloadVisualize
BU of 2oib by Molmil
Crystal structure of IRAK4 kinase domain apo form
Descriptor: Interleukin-1 receptor-associated kinase 4
Authors:Kuglstatter, A, Villasenor, A.G, Browner, M.F.
Deposit date:2007-01-10
Release date:2007-03-20
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Cutting Edge: IL-1 Receptor-Associated Kinase 4 Structures Reveal Novel Features and Multiple Conformations.
J.Immunol., 178, 2007
6L63
DownloadVisualize
BU of 6l63 by Molmil
Human Coagulation Factor XIIa (FXIIa) bound with the macrocyclic peptide F3 containing two (1S,2S)-2-ACHC residues
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ACETYL GROUP, ...
Authors:Sengoku, T, Katoh, T, Hirata, K, Suga, H, Ogata, K.
Deposit date:2019-10-26
Release date:2020-09-02
Last modified:2025-09-17
Method:X-RAY DIFFRACTION (3 Å)
Cite:Ribosomal synthesis and de novo discovery of bioactive foldamer peptides containing cyclic beta-amino acids.
Nat.Chem., 12, 2020
4FNS
DownloadVisualize
BU of 4fns by Molmil
Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus in complex with 1-deoxygalactonojirimycin
Descriptor: (2R,3S,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-triol, 1,2-ETHANEDIOL, Alpha-galactosidase AgaA, ...
Authors:Merceron, R, Foucault, M, Haser, R, Mattes, R, Watzlawick, H, Gouet, P.
Deposit date:2012-06-20
Release date:2012-10-03
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The molecular mechanism of the thermostable alpha-galactosidases AgaA and AgaB explained by X-ray crystallography and mutational studies
J.Biol.Chem., 287, 2012
1E0C
DownloadVisualize
BU of 1e0c by Molmil
SULFURTRANSFERASE FROM AZOTOBACTER VINELANDII
Descriptor: 1,2-ETHANEDIOL, MAGNESIUM ION, SULFATE ION, ...
Authors:Bordo, D, Deriu, D, Colnaghi, R, Carpen, A, Pagani, S, Bolognesi, M.
Deposit date:2000-03-23
Release date:2000-05-08
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The Crystal Structure of a Sulfurtransferase from Azotobacter Vinelandii Highlights the Evolutionary Relationship between the Rhodanese and Phosphatase Enzyme Families
J.Mol.Biol., 298, 2000
1UZQ
DownloadVisualize
BU of 1uzq by Molmil
Integrin binding cbEGF22-TB4-cbEGF33 fragment of human fibrillin-1, apo form cbEGF23 domain only.
Descriptor: FIBRILLIN-1
Authors:Lee, S.S.J, Knott, V, Harlos, K, Handford, P.A, Stuart, D.I.
Deposit date:2004-03-15
Release date:2004-04-08
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of the Integrin Binding Fragment from Fibrillin-1 Gives New Insights Into Microfibril Organization
Structure, 12, 2004

243531

数据于2025-10-22公开中

PDB statisticsPDBj update infoContact PDBjnumon