3D14

Crystal structure of mouse Aurora A (Asn186->Gly, Lys240->Arg, Met302->Leu) in complex with 1-{5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)-ethyl]- thiazol-2-yl}-3-(3-trifluoromethyl-phenyl)-urea

Summary for 3D14

Entry DOI	10.2210/pdb3d14/pdb
Related	1mq4 3D15
Descriptor	serine/threonine kinase 6, 1-{5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-1,3-thiazol-2-yl}-3-[3-(trifluoromethyl)phenyl]urea (3 entities in total)
Functional Keywords	aurora a, small-molecule inhibitor, kinase, transferase
Biological source	Mus musculus (Mouse)
Total number of polymer chains	1
Total formula weight	32013.66
Authors	Elling, R.A.,Baskaran, S.,Allen, D.A.,Oslob, J.D.,Romanowski, M.J. (deposition date: 2008-05-04, release date: 2008-08-26, Last modification date: 2023-08-30)
Primary citation	Oslob, J.D.,Romanowski, M.J.,Allen, D.A.,Baskaran, S.,Bui, M.,Elling, R.A.,Flanagan, W.M.,Fung, A.D.,Hanan, E.J.,Harris, S.,Heumann, S.A.,Hoch, U.,Jacobs, J.W.,Lam, J.,Lawrence, C.E.,McDowell, R.S.,Nannini, M.A.,Shen, W.,Silverman, J.A.,Sopko, M.M.,Tangonan, B.T.,Teague, J.,Yoburn, J.C.,Yu, C.H.,Zhong, M.,Zimmerman, K.M.,O'Brien, T.,Lew, W. Discovery of a potent and selective aurora kinase inhibitor. Bioorg.Med.Chem.Lett., 18:4880-4884, 2008 Cited by PubMed: 18678489 DOI: 10.1016/j.bmcl.2008.07.073 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation