4OCZ
Crystal structure of human soluble epoxide hydrolase complexed with 1-(1-isobutyrylpiperidin-4-yl)-3-(4-(trifluoromethyl)phenyl)urea
Summary for 4OCZ
Entry DOI | 10.2210/pdb4ocz/pdb |
Related | 4OD0 |
Descriptor | Bifunctional epoxide hydrolase 2, PHOSPHATE ION, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | domain-swapped dimer, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P34913 |
Total number of polymer chains | 1 |
Total formula weight | 63162.26 |
Authors | Lee, K.S.S.,Liu, J.,Wagner, K.M.,Pakhomova, S.,Dong, H.,Morriseau, C.,Fu, S.H.,Yang, J.,Wang, P.,Ulu, A.,Mate, C.,Nguyen, L.,Wullf, H.,Eldin, M.L.,Mara, A.A.,Newcomer, M.E.,Zeldin, D.C.,Hammock, B.D. (deposition date: 2014-01-09, release date: 2014-09-24, Last modification date: 2023-09-20) |
Primary citation | Lee, K.S.,Liu, J.Y.,Wagner, K.M.,Pakhomova, S.,Dong, H.,Morisseau, C.,Fu, S.H.,Yang, J.,Wang, P.,Ulu, A.,Mate, C.A.,Nguyen, L.V.,Hwang, S.H.,Edin, M.L.,Mara, A.A.,Wulff, H.,Newcomer, M.E.,Zeldin, D.C.,Hammock, B.D. Optimized inhibitors of soluble epoxide hydrolase improve in vitro target residence time and in vivo efficacy. J.Med.Chem., 57:7016-7030, 2014 Cited by PubMed: 25079952DOI: 10.1021/jm500694p PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.94 Å) |
Structure validation
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