5HJO

Murine endoplasmic reticulum alpha-glucosidase II with bound substrate analogue

Summary for 5HJO

• Entry DOI: 10.2210/pdb5hjo/pdb
• Descriptor: Neutral alpha-glucosidase AB, Glucosidase 2 subunit beta, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total)
• Functional Keywords: enzyme glycosyl hydrolase, gh31, quality control exoglycosidase, hydrolase
• Biological source: Mus musculus (Mouse); More
• Cellular location: Endoplasmic reticulum : Q8BHN3 O08795
• Total number of polymer chains: 4
• Total formula weight: 217311.79

Authors

Caputo, A.T.,Roversi, P.,Alonzi, D.S.,Kiappes, J.L.,Zitzmann, N. (deposition date: 2016-01-13, release date: 2016-07-27, Last modification date: 2020-07-29)

• Primary citation: Caputo, A.T.,Alonzi, D.S.,Marti, L.,Reca, I.B.,Kiappes, J.L.,Struwe, W.B.,Cross, A.,Basu, S.,Lowe, E.D.,Darlot, B.,Santino, A.,Roversi, P.,Zitzmann, N.; Structures of mammalian ER alpha-glucosidase II capture the binding modes of broad-spectrum iminosugar antivirals.; Proc.Natl.Acad.Sci.USA, 113:E4630-E4638, 2016; PubMed: 27462106; DOI: 10.1073/pnas.1604463113

Experimental method

X-RAY DIFFRACTION (2.29 Å)