5HJO
Murine endoplasmic reticulum alpha-glucosidase II with bound substrate analogue
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Neutral alpha-glucosidase AB | polymer | 857 | 97894.6 | 2 | UniProt (Q8BHN3) Pfam (PF13802) Pfam (PF01055) Pfam (PF21365) | Mus musculus (Mouse) | Alpha-glucosidase 2,Glucosidase II subunit alpha |
| 2 | B, D (B, D) | Glucosidase 2 subunit beta | polymer | 83 | 8912.6 | 2 | UniProt (O08795) Pfam (PF12999) | Mus musculus (Mouse) | 80K-H protein,Glucosidase II subunit beta,Protein kinase C substrate 60.1 kDa protein heavy chain,PKCSH |
| 3 | E, F (E, F) | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 2 | In PDB GlyTouCan (G81315DD) | |||
| 4 | G, H (G, H) | 2-deoxy-alpha-D-arabino-hexopyranose-(1-3)-D-glucal | branched | 292.3 | 2 | In PDB GlyTouCan (G58893KD) | |||
| 5 | I, X (A, C) | ACETATE ION | non-polymer | 59.0 | 2 | Chemie (ACT) PubChem (175) | Mus musculus | ||
| 6 | J, Y (A, C) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | Mus musculus | ||
| 7 | AA, BA, CA, DA, EA... (C, A) | FORMIC ACID | non-polymer | 46.0 | 20 | Chemie (FMT) PubChem (284) | Mus musculus | ||
| 8 | JA, U (D, B) | D-glucal | non-polymer | 146.1 | 2 | Chemie (DGO) PubChem (2734736) PubChem (25203073) PubChem (40488871) PubChem (89465) PubChem (114633) PubChem (51404084) PubChem (58120730) PubChem (59658630) PubChem (59928054) PubChem (68016543) PubChem (2734735) PubChem (89178695) PubChem (7168230) PubChem (7168231) PubChem (10510978) PubChem (12310006) PubChem (133617814) PubChem (149437880) | |||
| 9 | KA, LA, V, W (D, B) | CALCIUM ION | non-polymer | 40.1 | 4 | Chemie (CA) PubChem (271) | |||
| 10 | MA, NA, OA, PA (A, B, C, D) | water | water | 18.0 | 648 | Chemie (HOH) |
Sequence modifications
A, C: 33 - 944 (UniProt: Q8BHN3)
| PDB | External Database | Details |
|---|---|---|
| - | Val 186 | deletion |
| - | Pro 187 | deletion |
| - | Phe 188 | deletion |
| - | Ser 189 | deletion |
| - | Asp 190 | deletion |
| - | Lys 191 | deletion |
| - | Val 192 | deletion |
| - | Ser 193 | deletion |
| - | Leu 194 | deletion |
| - | Ala 195 | deletion |
| - | Leu 196 | deletion |
| - | Gly 197 | deletion |
| - | Ser 198 | deletion |
| - | Val 199 | deletion |
| - | Trp 200 | deletion |
| - | Asp 201 | deletion |
| - | Lys 202 | deletion |
| - | Ile 203 | deletion |
| - | Lys 204 | deletion |
| - | Asn 205 | deletion |
| - | Leu 206 | deletion |
| - | Phe 207 | deletion |
| - | Ser 208 | deletion |
| - | Arg 209 | deletion |
| - | Gln 210 | deletion |
| - | Glu 211 | deletion |
| - | Ser 212 | deletion |
| - | Lys 213 | deletion |
| - | Asp 214 | deletion |
| - | Pro 215 | deletion |
| - | Ala 216 | deletion |
| - | Glu 217 | deletion |
| - | Gly 218 | deletion |
| - | Asn 219 | deletion |
| - | Gly 220 | deletion |
| - | Ala 221 | deletion |
| - | Gln 222 | deletion |
| - | Pro 223 | deletion |
| - | Glu 224 | deletion |
| - | Ala 225 | deletion |
| - | Thr 226 | deletion |
| - | Pro 227 | deletion |
| - | Gly 228 | deletion |
| - | Asp 229 | deletion |
| - | Gly 230 | deletion |
| - | Asp 231 | deletion |
| - | Lys 232 | deletion |
| - | Pro 233 | deletion |
| - | Glu 234 | deletion |
| - | Glu 235 | deletion |
| - | Thr 236 | deletion |
| - | Gln 237 | deletion |
| - | Glu 238 | deletion |
| - | Lys 239 | deletion |
| - | Ala 240 | deletion |
| - | Glu 241 | deletion |
| - | Lys 242 | deletion |
| - | Asp 243 | deletion |
| - | Thr 351 | deletion |
| - | Ala 352 | deletion |
| - | Gly 353 | deletion |
| - | Lys 354 | deletion |
| - | Thr 355 | deletion |
| - | Leu 356 | deletion |
| - | Phe 357 | deletion |
| - | Gly 358 | deletion |
| - | Lys 359 | deletion |
| - | Met 360 | deletion |
| - | Leu 361 | deletion |
| - | Asp 362 | deletion |
| - | Tyr 363 | deletion |
| - | Leu 364 | deletion |
| - | Gln 365 | deletion |
| - | Gly 366 | deletion |
| - | Ser 367 | deletion |
| - | Gly 368 | deletion |
| - | Glu 369 | deletion |
| Thr 945 | - | expression tag |
| Ser 946 | - | expression tag |
| Val 947 | - | expression tag |
| Leu 948 | - | expression tag |
| Ile 949 | - | expression tag |
| Leu 950 | - | expression tag |
| Arg 951 | - | expression tag |
| Lys 952 | - | expression tag |
| Pro 953 | - | expression tag |
| Gly 954 | - | expression tag |
| Val 955 | - | expression tag |
| Ser 956 | - | expression tag |
| Val 957 | - | expression tag |
| Ala 958 | - | expression tag |
| Ser 959 | - | expression tag |
| Asp 960 | - | expression tag |
| Trp 961 | - | expression tag |
| Ser 962 | - | expression tag |
| Ile 963 | - | expression tag |
| His 964 | - | expression tag |
| Leu 965 | - | expression tag |
| Arg 966 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 213614.5 | |
| Branched | Number of molecules | 4 |
| Total formula weight | 2081.9 | |
| Non-Polymers* | Number of molecules | 30 |
| Total formula weight | 1615.3 | |
| All* | Total formula weight | 217311.8 |
