6NOG
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6nog by Molmil](/molmil-images/mine/6nog) | Poised-state Dot1L bound to the H2B-Ubiquitinated nucleosome | Descriptor: | 601 DNA Strand 1, 601 DNA Strand 2, Histone H2A type 1, ... | Authors: | Worden, E.J, Hoffmann, N.A, Wolberger, C. | Deposit date: | 2019-01-16 | Release date: | 2019-02-20 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Mechanism of Cross-talk between H2B Ubiquitination and H3 Methylation by Dot1L. Cell, 176, 2019
|
|
8R4U
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8r4u by Molmil](/molmil-images/mine/8r4u) | Structure of salt-inducible kinase 3 with inhibitors | Descriptor: | 8-[(5-azanyl-1,3-dioxan-2-yl)methyl]-6-[2-chloranyl-4-(3-fluoranylpyridin-2-yl)phenyl]-2-(methylamino)pyrido[2,3-d]pyrimidin-7-one, SULFATE ION, Serine/threonine-protein kinase SIK3, ... | Authors: | Kack, H, Oster, L. | Deposit date: | 2023-11-14 | Release date: | 2024-03-27 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.416 Å) | Cite: | The structures of salt-inducible kinase 3 in complex with inhibitors reveal determinants for binding and selectivity. J.Biol.Chem., 300, 2024
|
|
6NJ9
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6nj9 by Molmil](/molmil-images/mine/6nj9) | Active state Dot1L bound to the H2B-Ubiquitinated nucleosome, 2-to-1 complex | Descriptor: | 601 DNA Strand 1, 601 DNA Strand 2, Histone H2A type 1, ... | Authors: | Worden, E.J, Hoffmann, N.A, Wolberger, C. | Deposit date: | 2019-01-02 | Release date: | 2019-02-20 | Last modified: | 2021-06-16 | Method: | ELECTRON MICROSCOPY (2.96 Å) | Cite: | Mechanism of Cross-talk between H2B Ubiquitination and H3 Methylation by Dot1L. Cell, 176, 2019
|
|
6T7X
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6t7x by Molmil](/molmil-images/mine/6t7x) | Crystal structure of PCNA from P. abyssi | Descriptor: | DNA polymerase sliding clamp | Authors: | Madru, C, Raia, P, Hugonneau Beaufet, I, Delarue, M, Carroni, M, Sauguet, L. | Deposit date: | 2019-10-23 | Release date: | 2020-03-04 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural basis for the increased processivity of D-family DNA polymerases in complex with PCNA. Nat Commun, 11, 2020
|
|
6SYX
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6syx by Molmil](/molmil-images/mine/6syx) | Hydrogenase-2 variant R479K - reduced sample exposed to pure oxygen | Descriptor: | CARBONMONOXIDE-(DICYANO) IRON, CHLORIDE ION, FE3-S4 CLUSTER, ... | Authors: | Carr, S.B, Beaton, S.E, Evans, R.M, Armstrong, F.A. | Deposit date: | 2019-10-01 | Release date: | 2020-10-14 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Hydrogen activation by NiFe-hydrogenases - consolidating the role of the pendant arginine. To Be Published
|
|
6CQA
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6cqa by Molmil](/molmil-images/mine/6cqa) | E. coli DHFR complex with inhibitor AMPQD | Descriptor: | 7-[(3-aminophenyl)methyl]-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine, Dihydrofolate reductase, SULFATE ION | Authors: | Cao, H, Rodrigues, J, Benach, J, Wasserman, S, Morisco, L, Koss, J, Shakhnovich, E, Skolnick, J. | Deposit date: | 2018-03-14 | Release date: | 2019-01-09 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | The crystal structure of a tetrahydrofolate-bound dihydrofolate reductase reveals the origin of slow product release. Commun Biol, 1, 2018
|
|
8R4Q
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8r4q by Molmil](/molmil-images/mine/8r4q) | Salt inducible kinase 3 in complex with inhibitor | Descriptor: | 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile, SULFATE ION, Serine/threonine-protein kinase SIK3, ... | Authors: | Kack, H, Oster, L. | Deposit date: | 2023-11-14 | Release date: | 2024-03-27 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.838 Å) | Cite: | The structures of salt-inducible kinase 3 in complex with inhibitors reveal determinants for binding and selectivity. J.Biol.Chem., 300, 2024
|
|
8R4V
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8r4v by Molmil](/molmil-images/mine/8r4v) | Structure of Salt-inducible kinase 3 in complex with inhibitor | Descriptor: | 1-(2,4-dimethoxyphenyl)-3-(2,6-dimethylphenyl)-1-[6-[[4-(4-methylpiperazin-1-yl)phenyl]amino]pyrimidin-4-yl]urea, Serine/threonine-protein kinase SIK3 | Authors: | Kack, H, Oster, L. | Deposit date: | 2023-11-14 | Release date: | 2024-03-27 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | The structures of salt-inducible kinase 3 in complex with inhibitors reveal determinants for binding and selectivity. J.Biol.Chem., 300, 2024
|
|
8R4O
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8r4o by Molmil](/molmil-images/mine/8r4o) | Salt inducible kinase 3 in complex with inhibitor | Descriptor: | 2-[bis(fluoranyl)methoxy]-4-[6-(2-cyanopropan-2-yl)pyrazolo[1,5-a]pyridin-3-yl]-~{N}-[(1~{R},2~{S})-2-fluoranylcyclopropyl]-6-methoxy-benzamide, SULFATE ION, Serine/threonine-protein kinase SIK3, ... | Authors: | Kack, H, Oster, L. | Deposit date: | 2023-11-14 | Release date: | 2024-03-27 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.725 Å) | Cite: | The structures of salt-inducible kinase 3 in complex with inhibitors reveal determinants for binding and selectivity. J.Biol.Chem., 300, 2024
|
|
7RD1
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7rd1 by Molmil](/molmil-images/mine/7rd1) | The Capsid Structure of the ChAdOx1 viral vector/chimpanzee adenovirus Y25 | Descriptor: | Hexon protein, Hexon-interlacing protein, Penton protein, ... | Authors: | Baker, A.T, Boyd, R.J, Sarkar, D, Vermaas, J.V, Williams, D, Singharoy, A. | Deposit date: | 2021-07-08 | Release date: | 2021-12-15 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.07 Å) | Cite: | ChAdOx1 interacts with CAR and PF4 with implications for thrombosis with thrombocytopenia syndrome. Sci Adv, 7, 2021
|
|
7RG7
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7rg7 by Molmil](/molmil-images/mine/7rg7) | Crystal structure of nanoclamp8:VHH in complex with MTX | Descriptor: | MAGNESIUM ION, METHOTREXATE, nano CLostridial Antibody Mimetic Protein 8 VHH | Authors: | Guo, Z, Peat, T, Newman, J, Alexandrov, K. | Deposit date: | 2021-07-14 | Release date: | 2021-12-22 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.83 Å) | Cite: | Design of a methotrexate-controlled chemical dimerization system and its use in bio-electronic devices. Nat Commun, 12, 2021
|
|
6NQA
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6nqa by Molmil](/molmil-images/mine/6nqa) | Active state Dot1L bound to the H2B-Ubiquitinated nucleosome, 1-to-1 complex | Descriptor: | 601 DNA Strand 1, 601 DNA Strand 2, Histone H2A type 1, ... | Authors: | Worden, E.J, Hoffmann, N.A, Wolberger, C. | Deposit date: | 2019-01-19 | Release date: | 2019-02-20 | Last modified: | 2020-01-08 | Method: | ELECTRON MICROSCOPY (3.54 Å) | Cite: | Mechanism of Cross-talk between H2B Ubiquitination and H3 Methylation by Dot1L. Cell, 176, 2019
|
|
7RHR
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7rhr by Molmil](/molmil-images/mine/7rhr) | Cryo-EM structure of Xenopus Patched-1 in nanodisc | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ... | Authors: | Huang, P, Lian, T, Jiang, J, Salic, A. | Deposit date: | 2021-07-18 | Release date: | 2022-03-02 | Last modified: | 2022-03-23 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structural basis for catalyzed assembly of the Sonic hedgehog-Patched1 signaling complex. Dev.Cell, 57, 2022
|
|
6X5N
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6x5n by Molmil](/molmil-images/mine/6x5n) | Crystal structure of a stabilized PAN ENE bimolecular triplex with a GC-clamped polyA tail, in complex with Fab-BL-3,6 | Descriptor: | Heavy chain Fab Bl-3 6, Light chain Fab BL-3 6, SULFATE ION, ... | Authors: | Swain, M, Li, M, Woldawer, A, LeGrice, S.F.J. | Deposit date: | 2020-05-26 | Release date: | 2020-07-01 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Dynamic bulge nucleotides in the KSHV PAN ENE triple helix provide a unique binding platform for small molecule ligands. Nucleic Acids Res., 49, 2021
|
|
7RHQ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7rhq by Molmil](/molmil-images/mine/7rhq) | Cryo-EM structure of Xenopus Patched-1 in complex with GAS1 and Sonic Hedgehog | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | Authors: | Huang, P, Lian, T, Wierbowski, B, Garcia-Linares, S, Jiang, J, Salic, A. | Deposit date: | 2021-07-18 | Release date: | 2022-03-02 | Last modified: | 2022-03-23 | Method: | ELECTRON MICROSCOPY (3.53 Å) | Cite: | Structural basis for catalyzed assembly of the Sonic hedgehog-Patched1 signaling complex. Dev.Cell, 57, 2022
|
|
7BUT
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7but by Molmil](/molmil-images/mine/7but) | |
6OJ0
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6oj0 by Molmil](/molmil-images/mine/6oj0) | Cryo-EM reconstruction of Sulfolobus polyhedral virus 1 (SPV1) | Descriptor: | Structural protein VP4, Uncharacterized protein | Authors: | Wang, F, Liu, Y, Conway, J.F, Krupovic, M, Prangishvili, D, Egelman, E.H. | Deposit date: | 2019-04-10 | Release date: | 2019-10-02 | Last modified: | 2020-01-08 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | A packing for A-form DNA in an icosahedral virus. Proc.Natl.Acad.Sci.USA, 116, 2019
|
|
6X5M
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6x5m by Molmil](/molmil-images/mine/6x5m) | Crystal structure of a stabilized PAN ENE bimolecular triplex with a GC-clamped polyA tail, in complex with Fab-BL-3,6. | Descriptor: | Heavy chain Fab Bl-3 6, Light chain Fab BL-3 6, SULFATE ION, ... | Authors: | Swain, M, Li, M, Wlodawer, A, Le Grice, S.F.J. | Deposit date: | 2020-05-26 | Release date: | 2020-06-24 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Dynamic bulge nucleotides in the KSHV PAN ENE triple helix provide a unique binding platform for small molecule ligands. Nucleic Acids Res., 49, 2021
|
|
7XNA
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7xna by Molmil](/molmil-images/mine/7xna) | Crystal structure of somatostatin receptor 2 (SSTR2) with peptide antagonist CYN 154806 | Descriptor: | CYN 154806, Somatostatin receptor type 2,Endo-1,4-beta-xylanase | Authors: | Zhao, W, Han, S, Qiu, N, Feng, W, Lu, M, Yang, D, Wang, M.-W, Wu, B, Zhao, Q. | Deposit date: | 2022-04-28 | Release date: | 2022-08-03 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Structural insights into ligand recognition and selectivity of somatostatin receptors. Cell Res., 32, 2022
|
|
7XN9
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7xn9 by Molmil](/molmil-images/mine/7xn9) | Crystal structure of SSTR2 and L-054,522 complex | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Somatostatin receptor type 2,Endo-1,4-beta-xylanase, tert-butyl (2S)-6-azanyl-2-[[(2R,3S)-3-(1H-indol-3-yl)-2-[[4-(2-oxidanylidene-3H-benzimidazol-1-yl)piperidin-1-yl]carbonylamino]butanoyl]amino]hexanoate | Authors: | Zhao, W, Han, S, Qiu, N, Feng, W, Lu, M, Yang, D, Wang, M.-W, Wu, B, Zhao, Q. | Deposit date: | 2022-04-28 | Release date: | 2022-08-03 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural insights into ligand recognition and selectivity of somatostatin receptors. Cell Res., 32, 2022
|
|
7DSH
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7dsh by Molmil](/molmil-images/mine/7dsh) | Cryo-EM structure of Dnf1 from Saccharomyces cerevisiae in 90PS with AMPPCP (E1-ATP state) | Descriptor: | Alkylphosphocholine resistance protein LEM3, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... | Authors: | Xu, J, He, Y, Wu, X, Li, L. | Deposit date: | 2020-12-31 | Release date: | 2022-03-23 | Last modified: | 2022-03-30 | Method: | ELECTRON MICROSCOPY (3.67 Å) | Cite: | Conformational changes of a phosphatidylcholine flippase in lipid membranes. Cell Rep, 38, 2022
|
|
7DSI
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7dsi by Molmil](/molmil-images/mine/7dsi) | Cryo-EM structure of Dnf1 from Saccharomyces cerevisiae in yeast lipids with AMPPCP ( resting state ) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alkylphosphocholine resistance protein LEM3, ... | Authors: | Xu, J, He, Y, Wu, X, Li, L. | Deposit date: | 2020-12-31 | Release date: | 2022-03-23 | Last modified: | 2022-04-20 | Method: | ELECTRON MICROSCOPY (3.21 Å) | Cite: | Conformational changes of a phosphatidylcholine flippase in lipid membranes. Cell Rep, 38, 2022
|
|
7YKL
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7ykl by Molmil](/molmil-images/mine/7ykl) | Cryo-EM structure of Drg1 hexamer treated with AMPPNP | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, ATPase family gene 2 protein | Authors: | Ma, C.Y, Wu, D.M, Chen, Q, Gao, N. | Deposit date: | 2022-07-22 | Release date: | 2022-12-14 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (5.6 Å) | Cite: | Structural dynamics of AAA + ATPase Drg1 and mechanism of benzo-diazaborine inhibition. Nat Commun, 13, 2022
|
|
7YKT
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7ykt by Molmil](/molmil-images/mine/7ykt) | Cryo-EM structure of Drg1 hexamer in helical state treated with ADP/AMPPNP/benzo-diazaborine | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATPase family gene 2 protein | Authors: | Ma, C.Y, Wu, D.M, Chen, Q, Gao, N. | Deposit date: | 2022-07-23 | Release date: | 2022-12-14 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (5.9 Å) | Cite: | Structural dynamics of AAA + ATPase Drg1 and mechanism of benzo-diazaborine inhibition. Nat Commun, 13, 2022
|
|
7VS7
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7vs7 by Molmil](/molmil-images/mine/7vs7) | Crystal structure of the ectodomain of OsCERK1 in complex with chitin hexamer | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Chitin elicitor receptor kinase 1, ... | Authors: | Li, X. | Deposit date: | 2021-10-26 | Release date: | 2022-08-03 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.015 Å) | Cite: | Structural insight into chitin perception by chitin elicitor receptor kinase 1 of Oryza sativa. J Integr Plant Biol, 65, 2023
|
|