8R4Q

Salt inducible kinase 3 in complex with inhibitor

Summary for 8R4Q

Entry DOI	10.2210/pdb8r4q/pdb
Descriptor	Serine/threonine-protein kinase SIK3, scFvH1, 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile, ... (5 entities in total)
Functional Keywords	kinase inhibitor complex ampk-like salt-induced kinase, ligase
Biological source	Homo sapiens (human) More
Total number of polymer chains	12
Total formula weight	395846.53
Authors	Kack, H.,Oster, L. (deposition date: 2023-11-14, release date: 2024-03-27, Last modification date: 2024-05-08)
Primary citation	Oster, L.,Castaldo, M.,de Vries, E.,Edfeldt, F.,Pemberton, N.,Gordon, E.,Cederblad, L.,Kack, H. The structures of salt-inducible kinase 3 in complex with inhibitors reveal determinants for binding and selectivity. J.Biol.Chem., 300:107201-107201, 2024 Cited by PubMed: 38508313 DOI: 10.1016/j.jbc.2024.107201 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.838 Å)

Structure validation