8R4Q
Salt inducible kinase 3 in complex with inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, E, G, I... (A, C, E, G, I...) | Serine/threonine-protein kinase SIK3 | polymer | 328 | 37888.9 | 6 | UniProt (Q9Y2K2) Pfam (PF00069) Pfam (PF23312) | Homo sapiens (human) | |
| 2 | B, D, F, H, J... (B, D, F, H, J...) | scFvH1 | polymer | 265 | 27411.0 | 6 | Homo sapiens | ||
| 3 | M, O, R, U, W... (A, C, E, G, I...) | 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile | non-polymer | 530.4 | 6 | Chemie (DB8) | |||
| 4 | AA, N, P, Q, S... (K, A, C, E, G...) | SULFATE ION | non-polymer | 96.1 | 9 | Chemie (SO4) | |||
| 5 | BA, CA, DA, EA, FA... (A, B, C, D, E...) | water | water | 18.0 | 70 | Chemie (HOH) |
Sequence modifications
A, C, E, G, I, K: 59 - 385 (UniProt: Q9Y2K2)
| PDB | External Database | Details |
|---|---|---|
| Ser 58 | - | expression tag |
| Ser 121 | Cys 121 | engineered mutation |
| Ser 181 | Cys 181 | engineered mutation |
| Ser 333 | Cys 333 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 391799.3 | |
| Non-Polymers* | Number of molecules | 15 |
| Total formula weight | 4047.2 | |
| All* | Total formula weight | 395846.5 |
