6X5N
Crystal structure of a stabilized PAN ENE bimolecular triplex with a GC-clamped polyA tail, in complex with Fab-BL-3,6
Summary for 6X5N
Entry DOI | 10.2210/pdb6x5n/pdb |
Descriptor | Light chain Fab BL-3 6, Heavy chain Fab Bl-3 6, ggPAN RNA (39-MER), ... (6 entities in total) |
Functional Keywords | viral encoded rna, rna therapeutics, structure-function studies, small molecules binding, pan triplex, ggene, ggca9, rna, immune system-rna complex, immune system/rna |
Biological source | Mus musculus More |
Total number of polymer chains | 8 |
Total formula weight | 152041.16 |
Authors | Swain, M.,Li, M.,Woldawer, A.,LeGrice, S.F.J. (deposition date: 2020-05-26, release date: 2020-07-01, Last modification date: 2023-10-18) |
Primary citation | Swain, M.,Ageeli, A.A.,Kasprzak, W.K.,Li, M.,Miller, J.T.,Sztuba-Solinska, J.,Schneekloth, J.S.,Koirala, D.,Piccirili, J.,Fraboni, A.J.,Murelli, R.P.,Wlodawer, A.,Shapiro, B.A.,Baird, N.,Le Grice, S.F.J. Dynamic bulge nucleotides in the KSHV PAN ENE triple helix provide a unique binding platform for small molecule ligands. Nucleic Acids Res., 49:13179-13193, 2021 Cited by PubMed: 34871450DOI: 10.1093/nar/gkab1170 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.3 Å) |
Structure validation
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