7RHQ

Cryo-EM structure of Xenopus Patched-1 in complex with GAS1 and Sonic Hedgehog

Summary for 7RHQ

• Entry DOI: 10.2210/pdb7rhq/pdb
• Related: 7RHR
• EMDB information: 24466
• Descriptor: Patched-1, PALMITIC ACID, Sonic hedgehog protein N-product, ... (10 entities in total)
• Functional Keywords: gpcr, complex, membrane protein
• Biological source: Xenopus laevis (African clawed frog); More
• Total number of polymer chains: 3
• Total formula weight: 188925.72

Authors

Huang, P.,Lian, T.,Wierbowski, B.,Garcia-Linares, S.,Jiang, J.,Salic, A. (deposition date: 2021-07-18, release date: 2022-03-02, Last modification date: 2022-03-23)

• Primary citation: Huang, P.,Wierbowski, B.M.,Lian, T.,Chan, C.,Garcia-Linares, S.,Jiang, J.,Salic, A.; Structural basis for catalyzed assembly of the Sonic hedgehog-Patched1 signaling complex.; Dev.Cell, 57:670-685.e8, 2022; PubMed: 35231446; DOI: 10.1016/j.devcel.2022.02.008

Experimental method

ELECTRON MICROSCOPY (3.53 Å)