7RHQ
Cryo-EM structure of Xenopus Patched-1 in complex with GAS1 and Sonic Hedgehog
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Patched-1 | polymer | 1205 | 134622.4 | 1 | UniProt (Q98SW6) Pfam (PF12349) Pfam (PF02460) In PDB | Xenopus laevis (African clawed frog) | |
2 | C | Sonic hedgehog protein N-product | polymer | 192 | 21378.9 | 1 | UniProt (Q15465) Pfam (PF01085) In PDB | Homo sapiens (human) | ShhN,Shh N-terminal processed signaling domains,ShhNp |
3 | G | Growth arrest-specific protein 1 | polymer | 282 | 29546.8 | 1 | UniProt (P54826) Pfam (PF02351) In PDB | Homo sapiens (human) | GAS-1 |
4 | B, D, E | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 3 | In PDB GlyTouCan (G42666HT) | |||
5 | A, C | CHOLESTEROL | non-polymer | 386.7 | 2 | Chemie (CLR) | |||
6 | A | CHOLESTEROL HEMISUCCINATE | non-polymer | 486.7 | 1 | Chemie (Y01) | |||
7 | A | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
8 | C | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
9 | C | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) | |||
10 | C | PALMITIC ACID | non-polymer | 256.4 | 1 | Chemie (PLM) |
Sequence modifications
A: 1 - 1178 (UniProt: Q98SW6)
C: 24 - 197 (UniProt: Q15465)
G: 40 - 317 (UniProt: P54826)
PDB | External Database | Details |
---|---|---|
Ser 1179 | - | expression tag |
Ser 1180 | - | expression tag |
Ser 1181 | - | expression tag |
Pro 1182 | - | expression tag |
Ala 1183 | - | expression tag |
Ala 1184 | - | expression tag |
Ala 1185 | - | expression tag |
His 1186 | - | expression tag |
His 1187 | - | expression tag |
His 1188 | - | expression tag |
His 1189 | - | expression tag |
His 1190 | - | expression tag |
His 1191 | - | expression tag |
His 1192 | - | expression tag |
His 1193 | - | expression tag |
Glu 1194 | - | expression tag |
Asp 1195 | - | expression tag |
Gln 1196 | - | expression tag |
Val 1197 | - | expression tag |
Asp 1198 | - | expression tag |
Pro 1199 | - | expression tag |
Arg 1200 | - | expression tag |
Leu 1201 | - | expression tag |
Ile 1202 | - | expression tag |
Asp 1203 | - | expression tag |
Gly 1204 | - | expression tag |
Lys 1205 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Gly 130 | - | insertion |
Gly 130 | - | insertion |
Thr 130 | - | insertion |
Glu 130 | - | insertion |
Asp 130 | - | insertion |
Gln 130 | - | insertion |
Val 130 | - | insertion |
Asp 130 | - | insertion |
Pro 130 | - | insertion |
Arg 130 | - | insertion |
Leu 130 | - | insertion |
Ile 130 | - | insertion |
Asp 130 | - | insertion |
Gly 130 | - | insertion |
Lys 130 | - | insertion |
Ser 130 | - | insertion |
Gly 130 | - | insertion |
Gly 130 | - | insertion |
PDB | External Database | Details |
---|---|---|
Gly 36 | - | expression tag |
Pro 37 | - | expression tag |
Gly 38 | - | expression tag |
Ser 39 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 185548.1 | |
Branched | Number of molecules | 3 |
Total formula weight | 1273.2 | |
Non-Polymers* | Number of molecules | 9 |
Total formula weight | 2104.4 | |
All* | Total formula weight | 188925.7 |