7RHQ
Cryo-EM structure of Xenopus Patched-1 in complex with GAS1 and Sonic Hedgehog
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0008158 | molecular_function | hedgehog receptor activity |
| A | 0016020 | cellular_component | membrane |
| C | 0007267 | biological_process | cell-cell signaling |
| C | 0007275 | biological_process | multicellular organism development |
| G | 0005515 | molecular_function | protein binding |
| G | 0005886 | cellular_component | plasma membrane |
| G | 0008142 | molecular_function | oxysterol binding |
| G | 0008589 | biological_process | regulation of smoothened signaling pathway |
| G | 0010955 | biological_process | negative regulation of protein processing |
| G | 0016020 | cellular_component | membrane |
| G | 0035924 | biological_process | cellular response to vascular endothelial growth factor stimulus |
| G | 0042981 | biological_process | regulation of apoptotic process |
| G | 0045165 | biological_process | cell fate commitment |
| G | 0045930 | biological_process | negative regulation of mitotic cell cycle |
| G | 0048589 | biological_process | developmental growth |
| G | 0051726 | biological_process | regulation of cell cycle |
| G | 0060628 | biological_process | regulation of ER to Golgi vesicle-mediated transport |
| G | 0098552 | cellular_component | side of membrane |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Motif: {"description":"Cardin-Weintraub","evidences":[{"source":"PubMed","id":"23118222","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"20504762","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3MXW","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"10753901","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20504762","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3M1N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3MXW","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Lipidation: {"description":"N-palmitoyl cysteine","evidences":[{"source":"PubMed","id":"18534984","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31875564","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9593755","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Lipidation: {"description":"Cholesterol glycine ester","evidences":[{"source":"UniProtKB","id":"Q62226","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
