Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7RHQ

Cryo-EM structure of Xenopus Patched-1 in complex with GAS1 and Sonic Hedgehog

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008158	molecular_function	hedgehog receptor activity
A	0016020	cellular_component	membrane
C	0007267	biological_process	cell-cell signaling
C	0007275	biological_process	multicellular organism development
G	0005515	molecular_function	protein binding
G	0005886	cellular_component	plasma membrane
G	0008142	molecular_function	oxysterol binding
G	0008589	biological_process	regulation of smoothened signaling pathway
G	0010955	biological_process	negative regulation of protein processing
G	0016020	cellular_component	membrane
G	0030308	biological_process	negative regulation of cell growth
G	0035924	biological_process	cellular response to vascular endothelial growth factor stimulus
G	0042476	biological_process	odontogenesis
G	0042981	biological_process	regulation of apoptotic process
G	0043066	biological_process	negative regulation of apoptotic process
G	0045165	biological_process	cell fate commitment
G	0045880	biological_process	positive regulation of smoothened signaling pathway
G	0045930	biological_process	negative regulation of mitotic cell cycle
G	0048589	biological_process	developmental growth
G	0051726	biological_process	regulation of cell cycle
G	0060628	biological_process	regulation of ER to Golgi vesicle-mediated transport
G	0140597	molecular_function	protein carrier activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	18
Details	Transmembrane: {"description":"Helical; Name=TM1","evidences":[{"source":"PubMed","id":"35231446","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7RHQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7RHR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	611
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"35231446","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7RHQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7RHR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	18
Details	Transmembrane: {"description":"Helical; Name=TM2","evidences":[{"source":"PubMed","id":"35231446","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7RHQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7RHR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	48
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"35231446","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7RHQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7RHR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	25
Details	Transmembrane: {"description":"Helical; Name=TM3","evidences":[{"source":"PubMed","id":"35231446","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7RHQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7RHR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	19
Details	Transmembrane: {"description":"Helical; Name=TM4","evidences":[{"source":"PubMed","id":"35231446","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7RHQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7RHR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=TM5","evidences":[{"source":"PubMed","id":"35231446","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7RHQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7RHR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	23
Details	Transmembrane: {"description":"Helical; Name=TM6","evidences":[{"source":"PubMed","id":"35231446","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7RHQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7RHR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	21
Details	Transmembrane: {"description":"Helical; Name=TM7","evidences":[{"source":"PubMed","id":"35231446","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7RHQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7RHR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=TM8","evidences":[{"source":"PubMed","id":"35231446","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7RHQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7RHR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	21
Details	Transmembrane: {"description":"Helical; Name=TM9","evidences":[{"source":"PubMed","id":"35231446","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7RHQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7RHR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	19
Details	Transmembrane: {"description":"Helical; Name=TM10","evidences":[{"source":"PubMed","id":"35231446","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7RHQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7RHR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=TM11","evidences":[{"source":"PubMed","id":"35231446","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7RHQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7RHR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	25
Details	Transmembrane: {"description":"Helical; Name=TM12","evidences":[{"source":"PubMed","id":"35231446","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7RHQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7RHR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	160
Details	Domain: {"description":"SSD","evidences":[{"source":"PROSITE-ProRule","id":"PRU00199","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	319
Details	Region: {"description":"Extracellular domain 1 (ECD1)","evidences":[{"source":"PubMed","id":"35231446","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7RHQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7RHR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	256
Details	Region: {"description":"Extracellular domain 2 (ECD2)","evidences":[{"source":"PubMed","id":"35231446","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7RHQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7RHR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"35231446","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7RHR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"35231446","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7RHQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7RHR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI20
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"35231446","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7RHQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI21
Number of Residues	6
Details	Motif: {"description":"Cardin-Weintraub","evidences":[{"source":"PubMed","id":"23118222","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI22
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20504762","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29954986","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31127104","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31548691","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35231446","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3MXW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6DMY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6N7G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6N7H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6N7K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6RVD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7RHQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI23
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20504762","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29954986","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30139912","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31127104","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31548691","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35231446","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3MXW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6DMY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6E1H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6N7G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6N7H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6N7K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6RVD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7RHQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI24
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20504762","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31548691","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35231446","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3MXW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6RVD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7RHQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI25
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20504762","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30139912","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31548691","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35231446","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3MXW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6E1H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6RVD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7RHQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI26
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10753901","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20504762","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29954986","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30139912","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31127104","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31548691","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31555730","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35231446","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3M1N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3MXW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6DMY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6E1H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6N7G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6N7H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6N7K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6RMG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6RVD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7RHQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI27
Number of Residues	1
Details	Lipidation: {"description":"N-palmitoyl cysteine","evidences":[{"source":"PubMed","id":"18534984","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29995851","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30139912","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31127104","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31875564","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34112694","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9593755","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6E1H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7MHZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI28
Number of Residues	1
Details	Lipidation: {"description":"Cholesterol glycine ester","evidences":[{"source":"UniProtKB","id":"Q62226","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI29
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PROSITE-ProRule","id":"PRU00498","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)