6CQA
E. coli DHFR complex with inhibitor AMPQD
Summary for 6CQA
Entry DOI | 10.2210/pdb6cqa/pdb |
Descriptor | Dihydrofolate reductase, SULFATE ION, 7-[(3-aminophenyl)methyl]-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine, ... (4 entities in total) |
Functional Keywords | dhfr, dihydrofolate reductase, inhibitor, complex, oxidoreductase |
Biological source | Escherichia coli |
Total number of polymer chains | 1 |
Total formula weight | 19344.70 |
Authors | Cao, H.,Rodrigues, J.,Benach, J.,Wasserman, S.,Morisco, L.,Koss, J.,Shakhnovich, E.,Skolnick, J. (deposition date: 2018-03-14, release date: 2019-01-09, Last modification date: 2023-10-04) |
Primary citation | Cao, H.,Gao, M.,Zhou, H.,Skolnick, J. The crystal structure of a tetrahydrofolate-bound dihydrofolate reductase reveals the origin of slow product release. Commun Biol, 1:226-226, 2018 Cited by PubMed: 30564747DOI: 10.1038/s42003-018-0236-y PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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